Keith M Diaz1, Jeff Goldsmith2, Heather Greenlee2, Garrett Strizich2, Qibin Qi2, Yasmin Mossavar-Rahmani2, Denise C Vidot2, Christina Buelna2, Carrie E Brintz2, Tali Elfassy2, Linda C Gallo2, Martha L Daviglus2, Daniela Sotres-Alvarez2, Robert C Kaplan2. 1. From Center for Behavioral Cardiovascular Health, Department of Medicine, Columbia University Medical Center, New York, NY (K.M.D.); Department of Biostatistics (J.G.) and Department of Epidemiology (H.G.), Mailman School of Public Health, Columbia University, New York, NY; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (G.S., Q.Q., Y.M.-R., R.C.K.); Department of Psychology, University of Miami, Coral Gables, FL (D.C.V., C.E.B.); South Bay Latino Research Center, Graduate School of Public Health (C.B.), and Department of Psychology (L.C.G.), San Diego State University, CA; Department of Epidemiology & Public Health, University of Miami, FL (T.E.); Institute for Minority Health Research, University of Illinois at Chicago (M.L.D.); and Collaborative Studies Coordinating Center, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill (D.S.-A.). kd2442@columbia.edu. 2. From Center for Behavioral Cardiovascular Health, Department of Medicine, Columbia University Medical Center, New York, NY (K.M.D.); Department of Biostatistics (J.G.) and Department of Epidemiology (H.G.), Mailman School of Public Health, Columbia University, New York, NY; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (G.S., Q.Q., Y.M.-R., R.C.K.); Department of Psychology, University of Miami, Coral Gables, FL (D.C.V., C.E.B.); South Bay Latino Research Center, Graduate School of Public Health (C.B.), and Department of Psychology (L.C.G.), San Diego State University, CA; Department of Epidemiology & Public Health, University of Miami, FL (T.E.); Institute for Minority Health Research, University of Illinois at Chicago (M.L.D.); and Collaborative Studies Coordinating Center, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill (D.S.-A.).
Abstract
BACKGROUND: Excessive sedentary time is ubiquitous in developed nations and is associated with deleterious health outcomes. Few studies have examined whether the manner in which sedentary time is accrued (in short or long bouts) carries any clinical relevance. The purpose of this study was to examine the association of prolonged, uninterrupted sedentary behavior with glycemic biomarkers in a cohort of US Hispanic/Latino adults. METHODS: We studied 12 083 participants from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos), a population-based study of Hispanic/Latino adults 18 to 74 years of age. Homeostatic model assessment of insulin resistance and glycosylated hemoglobin were measured from a fasting blood sample, and 2-hour glucose was measured after an oral glucose tolerance test. Sedentary time was objectively measured with a hip-mounted accelerometer. Prolonged, uninterrupted sedentariness was expressed as mean sedentary bout length. RESULTS: After adjustment for potential confounders and moderate to vigorous physical activity, longer sedentary bout duration was dose-dependently associated with increased homeostatic model assessment of insulin resistance (P for trend<0.001) and 2-hour glucose levels (P for trend=0.015). These associations were not independent of total sedentary time; however, a significant interaction between sedentary bout duration and total sedentary time was observed. Evaluation of the joint association of total sedentary time and sedentary bout duration showed that participants in the upper quartile for both sedentary characteristics (ie, high total sedentary time and high sedentary bout duration) had the highest levels of homeostatic model assessment of insulin resistance (P<0.001 versus low group for both sedentary characteristics) and 2-hour glucose (P=0.002 versus low group for both sedentary characteristics). High total sedentary time or high sedentary bout duration alone were not associated with differences in any glycemic biomarkers. CONCLUSIONS: Accruing sedentary time in prolonged, uninterrupted bouts may be deleteriously associated with biomarkers of glucose regulation.
BACKGROUND: Excessive sedentary time is ubiquitous in developed nations and is associated with deleterious health outcomes. Few studies have examined whether the manner in which sedentary time is accrued (in short or long bouts) carries any clinical relevance. The purpose of this study was to examine the association of prolonged, uninterrupted sedentary behavior with glycemic biomarkers in a cohort of US Hispanic/Latino adults. METHODS: We studied 12 083 participants from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos), a population-based study of Hispanic/Latino adults 18 to 74 years of age. Homeostatic model assessment of insulin resistance and glycosylated hemoglobin were measured from a fasting blood sample, and 2-hour glucose was measured after an oral glucose tolerance test. Sedentary time was objectively measured with a hip-mounted accelerometer. Prolonged, uninterrupted sedentariness was expressed as mean sedentary bout length. RESULTS: After adjustment for potential confounders and moderate to vigorous physical activity, longer sedentary bout duration was dose-dependently associated with increased homeostatic model assessment of insulin resistance (P for trend<0.001) and 2-hour glucose levels (P for trend=0.015). These associations were not independent of total sedentary time; however, a significant interaction between sedentary bout duration and total sedentary time was observed. Evaluation of the joint association of total sedentary time and sedentary bout duration showed that participants in the upper quartile for both sedentary characteristics (ie, high total sedentary time and high sedentary bout duration) had the highest levels of homeostatic model assessment of insulin resistance (P<0.001 versus low group for both sedentary characteristics) and 2-hour glucose (P=0.002 versus low group for both sedentary characteristics). High total sedentary time or high sedentary bout duration alone were not associated with differences in any glycemic biomarkers. CONCLUSIONS: Accruing sedentary time in prolonged, uninterrupted bouts may be deleteriously associated with biomarkers of glucose regulation.
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