Qibin Qi1, Garrett Strizich2, Gina Merchant2, Daniela Sotres-Alvarez2, Christina Buelna2, Sheila F Castañeda2, Linda C Gallo2, Jianwen Cai2, Marc D Gellman2, Carmen R Isasi2, Ashley E Moncrieft2, Lisa Sanchez-Johnsen2, Neil Schneiderman2, Robert C Kaplan2. 1. From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.). qibin.qi@einstein.yu.edu. 2. From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
Abstract
BACKGROUND: Sedentary behavior is recognized as a distinct construct from lack of moderate-vigorous physical activity and is associated with deleterious health outcomes. Previous studies have primarily relied on self-reported data, whereas data on the relationship between objectively measured sedentary time and cardiometabolic biomarkers are sparse, especially among US Hispanics/Latinos. METHODS AND RESULTS: We examined associations of objectively measured sedentary time (via Actical accelerometers for 7 days) and multiple cardiometabolic biomarkers among 12 083 participants, aged 18 to 74 years, from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Hispanics/Latinos of diverse backgrounds (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American) were recruited from 4 US cities between 2008 and 2011. Sedentary time (<100 counts/min) was standardized to 16 hours/d of wear time. The mean sedentary time was 11.9 hours/d (74% of accelerometer wear time). After adjustment for moderate-vigorous physical activity and confounding variables, prolonged sedentary time was associated with decreased high-density lipoprotein cholesterol (P=0.04), and increased triglycerides, 2-hour glucose, fasting insulin, and homeostatic model assessment of insulin resistance (all P<0.0001). These associations were generally consistent across age, sex, Hispanic/Latino backgrounds, and physical activity levels. Even among individuals meeting physical activity guidelines, sedentary time was detrimentally associated with several cardiometabolic biomarkers (diastolic blood pressure, high-density lipoprotein cholesterol, fasting and 2-hour glucose, fasting insulin and homeostatic model assessment of insulin resistance; all P<0.05). CONCLUSIONS: Our large population-based, objectively derived data showed deleterious associations between sedentary time and cardiometabolic biomarkers, independent of physical activity, in US Hispanics/Latinos. Our findings emphasize the importance of reducing sedentary behavior for the prevention of cardiometabolic diseases, even in those who meet physical activity recommendations.
BACKGROUND: Sedentary behavior is recognized as a distinct construct from lack of moderate-vigorous physical activity and is associated with deleterious health outcomes. Previous studies have primarily relied on self-reported data, whereas data on the relationship between objectively measured sedentary time and cardiometabolic biomarkers are sparse, especially among US Hispanics/Latinos. METHODS AND RESULTS: We examined associations of objectively measured sedentary time (via Actical accelerometers for 7 days) and multiple cardiometabolic biomarkers among 12 083 participants, aged 18 to 74 years, from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Hispanics/Latinos of diverse backgrounds (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American) were recruited from 4 US cities between 2008 and 2011. Sedentary time (<100 counts/min) was standardized to 16 hours/d of wear time. The mean sedentary time was 11.9 hours/d (74% of accelerometer wear time). After adjustment for moderate-vigorous physical activity and confounding variables, prolonged sedentary time was associated with decreased high-density lipoprotein cholesterol (P=0.04), and increased triglycerides, 2-hour glucose, fasting insulin, and homeostatic model assessment of insulin resistance (all P<0.0001). These associations were generally consistent across age, sex, Hispanic/Latino backgrounds, and physical activity levels. Even among individuals meeting physical activity guidelines, sedentary time was detrimentally associated with several cardiometabolic biomarkers (diastolic blood pressure, high-density lipoprotein cholesterol, fasting and 2-hour glucose, fasting insulin and homeostatic model assessment of insulin resistance; all P<0.05). CONCLUSIONS: Our large population-based, objectively derived data showed deleterious associations between sedentary time and cardiometabolic biomarkers, independent of physical activity, in US Hispanics/Latinos. Our findings emphasize the importance of reducing sedentary behavior for the prevention of cardiometabolic diseases, even in those who meet physical activity recommendations.
Authors: Aviroop Biswas; Paul I Oh; Guy E Faulkner; Ravi R Bajaj; Michael A Silver; Marc S Mitchell; David A Alter Journal: Ann Intern Med Date: 2015-01-20 Impact factor: 25.391
Authors: Carlos J Rodriguez; Matthew Allison; Martha L Daviglus; Carmen R Isasi; Colleen Keller; Enrique C Leira; Latha Palaniappan; Ileana L Piña; Sarah M Ramirez; Beatriz Rodriguez; Mario Sims Journal: Circulation Date: 2014-07-14 Impact factor: 29.690
Authors: J Henson; T Yates; S J H Biddle; C L Edwardson; K Khunti; E G Wilmot; L J Gray; T Gorely; M A Nimmo; M J Davies Journal: Diabetologia Date: 2013-03-01 Impact factor: 10.122
Authors: C L Falconer; A R Cooper; J P Walhin; D Thompson; A S Page; T J Peters; A A Montgomery; D J Sharp; C M Dayan; R C Andrews Journal: Nutr Metab Cardiovasc Dis Date: 2014-04-26 Impact factor: 4.222
Authors: Gerardo Heiss; Michelle L Snyder; Yanping Teng; Neil Schneiderman; Maria M Llabre; Catherine Cowie; Mercedes Carnethon; Robert Kaplan; Aida Giachello; Linda Gallo; Laura Loehr; Larissa Avilés-Santa Journal: Diabetes Care Date: 2014-08 Impact factor: 19.112
Authors: Neil Schneiderman; Maria Llabre; Catherine C Cowie; Janice Barnhart; Mercedes Carnethon; Linda C Gallo; Aida L Giachello; Gerardo Heiss; Robert C Kaplan; Lisa M LaVange; Yanping Teng; Leonel Villa-Caballero; M Larissa Avilés-Santa Journal: Diabetes Care Date: 2014-08 Impact factor: 19.112
Authors: Ei Ei Khaing Nang; Agus Salim; Yi Wu; E Shyong Tai; Jeannette Lee; Rob M Van Dam Journal: Int J Behav Nutr Phys Act Date: 2013-05-30 Impact factor: 6.457
Authors: Jonathan T Unkart; Matthew A Allison; Humberto Parada; Michael H Criqui; Qibin Qi; Keith M Diaz; Jordan A Carlson; Daniela Sotres-Alvarez; Robert J Ostfeld; Leopoldo Raij; John Bellettiere Journal: Am Heart J Date: 2020-02-08 Impact factor: 4.749
Authors: Keith M Diaz; Jeff Goldsmith; Heather Greenlee; Garrett Strizich; Qibin Qi; Yasmin Mossavar-Rahmani; Denise C Vidot; Christina Buelna; Carrie E Brintz; Tali Elfassy; Linda C Gallo; Martha L Daviglus; Daniela Sotres-Alvarez; Robert C Kaplan Journal: Circulation Date: 2017-08-23 Impact factor: 29.690
Authors: Jun Li; Simin Hua; Guo-Chong Chen; Garrett Strizich; Mark H Kuniholm; Zhilei Shan; Gregory A Talavera; Sheila F Castañeda; Marc D Gellman; Jianwen Cai; Scott J Cotler; Xuehong Zhang; Frank B Hu; Robert Kaplan; Carmen R Isasi; Qibin Qi Journal: Liver Int Date: 2020-05-25 Impact factor: 5.828
Authors: Honghuang Lin; Mayank Sardana; Yuankai Zhang; Chunyu Liu; Ludovic Trinquart; Emelia J Benjamin; Emily S Manders; Kelsey Fusco; Jelena Kornej; Michael M Hammond; Nicole L Spartano; Chathurangi H Pathiravasan; Vik Kheterpal; Chris Nowak; Belinda Borrelli; Joanne M Murabito; David D McManus Journal: Circ Res Date: 2020-08-26 Impact factor: 17.367
Authors: Xiaonan Xue; Qibin Qi; Daniela Sotres-Alvarez; Scott C Roesch; Maria M Llabre; Sierra A Bainter; Yasmin Mossavar-Rahmani; Robert Kaplan; Tao Wang Journal: Stat Med Date: 2020-09-18 Impact factor: 2.373
Authors: Keith M Diaz; Virginia J Howard; Brent Hutto; Natalie Colabianchi; John E Vena; Monika M Safford; Steven N Blair; Steven P Hooker Journal: Ann Intern Med Date: 2017-09-12 Impact factor: 25.391