Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Differential tissue expression of the glutathione transferase multigene family.

Literature DB >> 2879532

Differential tissue expression of the glutathione transferase multigene family.

S E Pemble, J B Taylor, R K Craig, B Ketterer.

Abstract

The content of GSH transferase mRNAs in poly(A)-containing RNA isolated from eight rat tissues was examined by immunoprecipitation of cell-free translation products and by Northern blotting. Considerable tissue-specific distribution and heterogeneity of immunoprecipitable GSH transferase subunits 1 and 2 synthesized in vitro was observed. These results were confirmed by Northern blotting using a 32P-labelled subunit 1 cDNA probe. The same probe, used in a Southern blot analysis of genomic DNA, provided confirmation that GSH transferase subunits 1 and 2 comprise a multigenic family in the rat. The results show that the selection of cDNA clones coding for chosen subunits can be made easier by making use of qualitative and quantitative tissue differences in GSH transferase mRNAs.

Entities: Chemical Species

Mesh：

Substances：

Year: 1986 PMID： 2879532 PMCID： PMC1147146 DOI： 10.1042/bj2380373

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

23 in total

1. Tissue-specific expression of the rat glutathione S-transferases.

Authors: C P Tu; M J Weiss; N Q Li; C C Reddy
Journal: J Biol Chem Date: 1983-04-25 Impact factor: 5.157

2. Construction and characterization of a plasmid containing complementary DNA to mRNA encoding the N-terminal amino acid sequence of the rat glutathione transferase Ya subunit.

Authors: J B Taylor; R K Craig; D Beale; B Ketterer
Journal: Biochem J Date: 1984-04-01 Impact factor: 3.857

3. The construction and partial characterization of plasmids containing complementary DNA sequences to human calcitonin precursor polyprotein.

Authors: J Allison; L Hall; I MacIntyre; R K Craig
Journal: Biochem J Date: 1981-12-01 Impact factor: 3.857

4. The construction, identification and partial characterization of plasmids containing guinea-pig milk protein complementary DNA sequences.

Authors: R K Craig; L Hall; D Parker; P N Campbell
Journal: Biochem J Date: 1981-03-15 Impact factor: 3.857

5. Rat liver glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital.

Authors: C B Pickett; C A Telakowski-Hopkins; G J Ding; L Argenbright; A Y Lu
Journal: J Biol Chem Date: 1984-04-25 Impact factor: 5.157

6. Rat liver glutathione S-transferases. A study of the structure of the basic YbYb-containing enzymes.

Authors: J D Hayes
Journal: Biochem J Date: 1983-09-01 Impact factor: 3.857

7. Isolation, properties and tissue distribution of rat glutathione transferase E.

Authors: D J Meyer; L G Christodoulides; K Hong Tan; B Ketterer
Journal: FEBS Lett Date: 1984-08-06 Impact factor: 4.124

8. Evidence that the Yb subunits of hepatic glutathione transferases represent two different but related families of polypeptides.

Authors: D Beale; D J Meyer; J B Taylor; B Ketterer
Journal: Eur J Biochem Date: 1983-12-01

Differential tissue expression of the glutathione transferase multigene family.

1. Tissue-specific expression of the rat glutathione S-transferases.

2. Construction and characterization of a plasmid containing complementary DNA to mRNA encoding the N-terminal amino acid sequence of the rat glutathione transferase Ya subunit.

3. The construction and partial characterization of plasmids containing complementary DNA sequences to human calcitonin precursor polyprotein.

4. The construction, identification and partial characterization of plasmids containing guinea-pig milk protein complementary DNA sequences.

5. Rat liver glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital.

6. Rat liver glutathione S-transferases. A study of the structure of the basic YbYb-containing enzymes.

7. Isolation, properties and tissue distribution of rat glutathione transferase E.

8. Evidence that the Yb subunits of hepatic glutathione transferases represent two different but related families of polypeptides.

9. Glutathione S-transferase Ya subunit is coded by a multigene family located on a single mouse chromosome.

10. The nucleotide sequence of a rat liver glutathione S-transferase subunit cDNA clone.

1. The separation of glutathione transferase subunits by using reverse-phase high-pressure liquid chromatography.

2. Tissue distribution of rat glutathione transferase subunit 7, a hepatoma marker.

3. Purification and kinetic mechanism of the major glutathione S-transferase from bovine brain.