Fábio S Ferreira1, João M S Pereira1,2, Aldina Reis1, Mafalda Sanches3, João V Duarte1,3, Leonor Gomes4, Carolina Moreno4, Miguel Castelo-Branco5,6,7. 1. Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Azinhaga Santa Comba, Celas, 3000-548, Coimbra, Portugal. 2. Laboratory of Biostatistics and Medical Informatics, Institute for Biomedical Imaging in Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Azinhaga Santa Comba, Celas, 3000-548, Coimbra, Portugal. 3. CiBIT, Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Azinhaga Santa Comba, Celas, 3000-548, Coimbra, Portugal. 4. Department of Endocrinology, Coimbra Hospital and Universitary Centre (CHUC), Coimbra, Portugal. 5. Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Azinhaga Santa Comba, Celas, 3000-548, Coimbra, Portugal. mcbranco@fmed.uc.pt. 6. Laboratory of Biostatistics and Medical Informatics, Institute for Biomedical Imaging in Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Azinhaga Santa Comba, Celas, 3000-548, Coimbra, Portugal. mcbranco@fmed.uc.pt. 7. CiBIT, Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Azinhaga Santa Comba, Celas, 3000-548, Coimbra, Portugal. mcbranco@fmed.uc.pt.
Abstract
BACKGROUND: It is known that diabetic patients have changes in cortical morphometry as compared to controls, but it remains to be clarified whether the visual cortex is a disease target, even when diabetes complications such as retinopathy are absent. Therefore, we compared type 2 diabetes patients without diabetic retinopathy with control subjects using magnetic resonance imaging to assess visual cortical changes when retinal damage is not yet present. METHODS: We performed T1-weighted imaging in 24 type 2 diabetes patients without diabetic retinopathy and 27 age- and gender-matched controls to compare gray matter changes in the occipital cortex between groups using voxel based morphometry. RESULTS: Patients without diabetic retinopathy showed reduced gray matter volume in the occipital lobe when compared with controls. CONCLUSIONS: Reduced gray matter volume in the occipital cortex was found in diabetic patients without retinal damage. We conclude that cortical early visual processing regions may be affected in diabetic patients even before retinal damage occurs.
BACKGROUND: It is known that diabeticpatients have changes in cortical morphometry as compared to controls, but it remains to be clarified whether the visual cortex is a disease target, even when diabetes complications such as retinopathy are absent. Therefore, we compared type 2 diabetespatients without diabetic retinopathy with control subjects using magnetic resonance imaging to assess visual cortical changes when retinal damage is not yet present. METHODS: We performed T1-weighted imaging in 24 type 2 diabetespatients without diabetic retinopathy and 27 age- and gender-matched controls to compare gray matter changes in the occipital cortex between groups using voxel based morphometry. RESULTS:Patients without diabetic retinopathy showed reduced gray matter volume in the occipital lobe when compared with controls. CONCLUSIONS: Reduced gray matter volume in the occipital cortex was found in diabeticpatients without retinal damage. We conclude that cortical early visual processing regions may be affected in diabeticpatients even before retinal damage occurs.
Entities:
Keywords:
DARTEL; Diabetic retinopathy; T1-w sMRI; Type 2 diabetes; VBM
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