PURPOSE: To evaluate the presence of central nervous system degeneration in patients with low-tension glaucoma using magnetic resonance imaging. METHOD: Ten patients with low-tension glaucoma and ten age-matched control subjects underwent magnetic resonance imaging. Cortical atrophy and cerebral infarcts were graded from "0" (normal) to "3," which was done subjectively by two neuroradiologists independently in a masked fashion. Midsagittal corpus callosum section was evaluated by measuring the thickness and cross-sectional area. RESULTS: There was a significantly greater extent of cerebral infarcts in the patients with low-tension glaucoma (P = 0.02). The thickness of the body (P = 0.03) and genu (P = 0.04) of the corpus callosum were thinner in the patients with low-tension glaucoma. The corpus callosum cross-sectional area was smaller in the low-tension glaucoma group (P = 0.04). There were no significant differences in the other parameters in this study. CONCLUSION: This study suggests a greater extent of cerebral infarcts and corpus callosum atrophy in patients with low-tension glaucoma. This may imply a greater degree of neuronal degeneration, possibly on an ischemic basis in low-tension glaucoma.
PURPOSE: To evaluate the presence of central nervous system degeneration in patients with low-tension glaucoma using magnetic resonance imaging. METHOD: Ten patients with low-tension glaucoma and ten age-matched control subjects underwent magnetic resonance imaging. Cortical atrophy and cerebral infarcts were graded from "0" (normal) to "3," which was done subjectively by two neuroradiologists independently in a masked fashion. Midsagittal corpus callosum section was evaluated by measuring the thickness and cross-sectional area. RESULTS: There was a significantly greater extent of cerebral infarcts in the patients with low-tension glaucoma (P = 0.02). The thickness of the body (P = 0.03) and genu (P = 0.04) of the corpus callosum were thinner in the patients with low-tension glaucoma. The corpus callosum cross-sectional area was smaller in the low-tension glaucoma group (P = 0.04). There were no significant differences in the other parameters in this study. CONCLUSION: This study suggests a greater extent of cerebral infarcts and corpus callosum atrophy in patients with low-tension glaucoma. This may imply a greater degree of neuronal degeneration, possibly on an ischemic basis in low-tension glaucoma.
Authors: Fábio S Ferreira; João M S Pereira; Aldina Reis; Mafalda Sanches; João V Duarte; Leonor Gomes; Carolina Moreno; Miguel Castelo-Branco Journal: Graefes Arch Clin Exp Ophthalmol Date: 2017-08-04 Impact factor: 3.117
Authors: Robert O Duncan; Pamela A Sample; Christopher Bowd; Robert N Weinreb; Linda M Zangwill Journal: Vision Res Date: 2012-03-29 Impact factor: 1.886
Authors: Vasiliki Katsi; Antonios N Pavlidis; Manolis S Kallistratos; Athanasios Fitsios; Athanasios Bratsas; Dimitris Tousoulis; Christodoulos Stefanadis; Athanasios J Manolis; Ioannis Kallikazaros Journal: N Am J Med Sci Date: 2013-08