Literature DB >> 2874241

Classification of beta-blocking agents by their inhibitory effects on phospholipase activity.

S Nagai, S Sugiyama, T Ozawa.   

Abstract

The inhibitory effects of beta-blocking agents against the action of phospholipase (PLase) were investigated. Using micelles of dimyristoyl (-)-alpha-phosphatidylcholine (DMPC) as a substrate, myristic acid (MA) released from DMPC by PLase A2 was determined by gas chromatography. Beta-Blocking agents were divided into 4 groups depending on their inhibitory effects on PLase. Their inhibitory effects on PLase could be due to their displacing ability with Ca++ on membrane phospholipids, since Ca++ is an essential factor for the activation of PLase.

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Year:  1986        PMID： 2874241     DOI： 10.1253/jcj.50.238

Source DB:  PubMed          Journal:  Jpn Circ J        ISSN： 0047-1828


  5 in total

1.  Membrane perturbing activity of beta-adrenoceptor blocking drugs in isolated rat mast cells.

Authors:  R Nosál; K Drábiková; J Pecivová; K Ondrias
Journal:  Agents Actions       Date:  1989-04

2.  The role of phospholipase in plasmocid-induced mitochondrial dysfunction in rat hearts.

Authors:  N Hieda; S Sugiyama; Y Ogawa; T Ito; T Satake; T Ozawa
Journal:  Arch Toxicol       Date:  1988-08       Impact factor: 5.153

3.  Atenolol, exaprolol and mast cell membranes.

Authors:  J Pecivová; K Drábiková; V Jancinová; M Petríková; R Nosál
Journal:  Agents Actions       Date:  1991-05

4.  Effect of beta-adrenoceptor blocking drugs on 32P incorporation into and arachidonic acid liberation from phospholipids in stimulated rat mast cells.

Authors:  J Pecivová; K Drábiková; R Nosál
Journal:  Agents Actions       Date:  1989-04

5.  Pasteurella haemolytica leukotoxin induces histamine release from bovine pulmonary mast cells.

Authors:  T E Adusu; P D Conlon; P E Shewen; W D Black
Journal:  Can J Vet Res       Date:  1994-01       Impact factor: 1.310
  5 in total

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