Literature DB >> 2473627

Membrane perturbing activity of beta-adrenoceptor blocking drugs in isolated rat mast cells.

R Nosál1, K Drábiková, J Pecivová, K Ondrias.   

Abstract

Beta-adrenoceptor blocking (BAB) drugs perturb the membranes of isolated rat mast cells. Membrane fluidisation was temperature dependent and was determined by the liposolubility of the BAB drugs. The secretory index, evaluated as the ratio between histamine liberation and degranulation, correlated with the membrane order parameter of the mast cell membranes. The rank order of potency for mast cell activation and membrane fluidisation was: exaprolol greater than propranolol greater than metipranolol greater than atenolol.

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Year:  1989        PMID： 2473627     DOI： 10.1007/bf02222191

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  9 in total

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Journal:  Biochim Biophys Acta       Date:  1978-09-29

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Journal:  Eur J Respir Dis Suppl       Date:  1982

3.  On the relationship between incorporation of 32P into phospholipids and binding of beta-adrenoceptor blocking drugs to isolated mast cells.

Authors:  J Pecivová; K Drábiková; V Jancinová; R Nosál
Journal:  Agents Actions       Date:  1988-04

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Authors:  R Nosál'; V Jancinová; E Ondriasová; M Pesák
Journal:  Bratisl Lek Listy       Date:  1987-02       Impact factor: 1.278

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Journal:  Jpn Circ J       Date:  1986-03

6.  The interaction of beta-adrenoceptor blocking drugs with platelet aggregation, calcium displacement and fluidization of the membrane.

Authors:  R Nosál; V Jancinová; K Ondrias; J Jakubovský; P Balgavý
Journal:  Biochim Biophys Acta       Date:  1985-12-05

7.  On the interaction of beta-adrenoceptor-blocking drugs with isolated mast cells.

Authors:  R Nosál; J Pecivová; K Drábiková
Journal:  Agents Actions       Date:  1985-09

8.  Evidence for intracellular histamine liberation in isolated rat mast cells.

Authors:  R Nosál; J Pecivova; K Drábiková
Journal:  Agents Actions       Date:  1982-12

9.  Histamine liberation and membrane fluidisation of mast cells exposed to the beta-adrenoceptor blocking drug propranolol.

Authors:  R Nosál; K Ondrias; J Pecivová; K Drábiková
Journal:  Agents Actions       Date:  1988-04
  9 in total
  5 in total

1.  Comparative studies on inflammatory reactions induced by non-immunological and immunological stimuli in an air pouch and in a carboxymethyl cellulose (CMC)-induced inflammatory pouch.

Authors:  M Isaji; J Naito
Journal:  Int J Exp Pathol       Date:  1992-04       Impact factor: 1.925

2.  Atenolol, exaprolol and mast cell membranes.

Authors:  J Pecivová; K Drábiková; V Jancinová; M Petríková; R Nosál
Journal:  Agents Actions       Date:  1991-05

3.  The effect of beta-adrenoceptor blocking drugs on histamine liberation, prostaglandin synthesis and phospholipid turnover in isolated mast cells stimulated with concanavalin A.

Authors:  K Drábiková; J Pecivová; M Petríková; V Jancinová; R Nosál
Journal:  Agents Actions       Date:  1990-04

4.  Histamine liberation as a result of nonreceptor interaction.

Authors:  R Nosál; K Drábiková; J Pecivová; J Jakubovský
Journal:  Agents Actions       Date:  1990-04

5.  Tracheal ciliary beat frequency in baboons: effects of peripheral histamine and capsaicin.

Authors:  W M Hameister; L B Wong; D B Yeates
Journal:  Agents Actions       Date:  1992-03
  5 in total

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