Yunshu Wu 1 , Chenchen Zhou 1 , Quan Yuan 1 Show Affiliations »
Abstract
BACKGROUND: Epigenetic modifications have been evidenced to participate in eukaryotic stem cell fate decision. Among the most studied, 5-methylcytosine (m5C) and its derivatives are wellestablished epigenetic codes that play important roles in stem cell pluripotency and differentiation. Based on improved detection techniques, recent studies have succeeded in defining N6-adenine methylation (m6A) in eukaryotic DNA and RNA. The abundant m6A methylation in RNA was shown to be involved in multiple cellular metabolisms while the presence and functional potential of DNA m6A methylation in different species advanced our knowledge in the m6A-mediated biological processes. CONCLUSION: m6A modification has been observed during embryogenesis and has been proposed to fine-tune stem cell regulation. The m6A methyltransferases and demethylases work together to control the dynamic state of m6A marks in genomic DNA and RNA to ensure proper cell fate transition and determination, which are vital to the development and survival of eukaryotes. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Epigenetic modifications have been evidenced to participate in eukaryotic stem cell fate decision. Among the most studied, 5-methylcytosine (m5C ) and its derivatives are wellestablished epigenetic codes that play important roles in stem cell pluripotency and differentiation. Based on improved detection techniques, recent studies have succeeded in defining N6-adenine methylation (m6A ) in eukaryotic DNA and RNA. The abundant m6A methylation in RNA was shown to be involved in multiple cellular metabolisms while the presence and functional potential of DNA m6A methylation in different species advanced our knowledge in the m6A -mediated biological processes. CONCLUSION: m6A modification has been observed during embryogenesis and has been proposed to fine-tune stem cell regulation. The m6A methyltransferases and demethylases work together to control the dynamic state of m6A marks in genomic DNA and RNA to ensure proper cell fate transition and determination, which are vital to the development and survival of eukaryotes. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Chemical
Gene
Keywords:
N6-adenine methylation (m6A); cell differentiation; epigenetic modification; eukaryotes; pluripotency; stem cell
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Year: 2018
PMID： 28637404 DOI： 10.2174/1574888X12666170621125457
Source DB: PubMed Journal: Curr Stem Cell Res Ther ISSN： 1574-888X Impact factor: 3.828