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Literature DB >> 12615220

P. aeruginosa quorum-sensing systems and virulence.

Abstract

Quorum sensing is an important mechanism for the regulation of genes in many Gram-negative and Gram-positive bacteria. In the opportunistic pathogen Pseudomonas aeruginosa, the absence of one or more components of the quorum-sensing system results in a significant reduction in virulence. Recent advances in the past year have demonstrated that the quorum-sensing signal molecule 3O-C(12)-HSL is also a potent stimulator of multiple eukaryotic cells and thus may alter the host response during P. aeruginosa infections. Therefore, via the regulation of multiple factors and the production of 3O-C(12)-HSL, quorum-sensing systems have a significant effect on the virulence of the bacteria and also on how the host responds to P. aeruginosa infections.

Entities: Disease Species

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Year: 2003 PMID： 12615220 DOI： 10.1016/s1369-5274(03)00008-0

Source DB: PubMed Journal: Curr Opin Microbiol ISSN： 1369-5274 Impact factor: 7.934

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Cited

208 in total

1. Attenuation of virulence in pathogenic bacteria using synthetic quorum-sensing modulators under native conditions on plant hosts.

Authors: Andrew G Palmer; Evan Streng; Helen E Blackwell
Journal: ACS Chem Biol Date: 2011-10-06 Impact factor: 5.100

2. Biofilms 2003: emerging themes and challenges in studies of surface-associated microbial life.

Authors: Matthew R Parsek; Clay Fuqua
Journal: J Bacteriol Date: 2004-07 Impact factor: 3.490

3. Bacterial quorum-sensing signals are inactivated by mammalian cells.

Authors: J Woodland Hastings
Journal: Proc Natl Acad Sci U S A Date: 2004-03-15 Impact factor: 11.205

4. Down regulation of virulence factors of Pseudomonas aeruginosa by salicylic acid attenuates its virulence on Arabidopsis thaliana and Caenorhabditis elegans.

Authors: B Prithiviraj; H P Bais; T Weir; B Suresh; E H Najarro; B V Dayakar; H P Schweizer; J M Vivanco
Journal: Infect Immun Date: 2005-09 Impact factor: 3.441

5. Two novel synthetic peptides inhibit quorum sensing-dependent biofilm formation and some virulence factors in Pseudomonas aeruginosa PAO1.

Authors: Mostafa N Taha; Amal E Saafan; A Ahmedy; Eman El Gebaly; Ahmed S Khairalla
Journal: J Microbiol Date: 2019-06-27 Impact factor: 3.422

10. Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor.

Authors: Yaozhong Zou; Satish K Nair
Journal: Chem Biol Date: 2009-09-25

P. aeruginosa quorum-sensing systems and virulence.

1. Attenuation of virulence in pathogenic bacteria using synthetic quorum-sensing modulators under native conditions on plant hosts.

2. Biofilms 2003: emerging themes and challenges in studies of surface-associated microbial life.

3. Bacterial quorum-sensing signals are inactivated by mammalian cells.

4. Down regulation of virulence factors of Pseudomonas aeruginosa by salicylic acid attenuates its virulence on Arabidopsis thaliana and Caenorhabditis elegans.

5. Two novel synthetic peptides inhibit quorum sensing-dependent biofilm formation and some virulence factors in Pseudomonas aeruginosa PAO1.

6. Highly Potent, Chemically Stable Quorum Sensing Agonists for Vibrio Cholerae.

7. The quorum-quenching metallo-gamma-lactonase from Bacillus thuringiensis exhibits a leaving group thio effect.

8. Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators.

9. Immunoproteomics to examine cystic fibrosis host interactions with extracellular Pseudomonas aeruginosa proteins.

10. Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor.