Literature DB >> 28521017

CPC2: a fast and accurate coding potential calculator based on sequence intrinsic features.

Yu-Jian Kang1, De-Chang Yang1, Lei Kong1, Mei Hou1, Yu-Qi Meng1, Liping Wei1, Ge Gao1.   

Abstract

With advances in next-generation sequencing technologies, numerous novel transcripts in a large number of organisms have been identified. With the goal of fast, accurate assessment of the coding ability of RNA transcripts, we upgraded the coding potential calculator CPC1 to CPC2. CPC2 runs ∼1000 times faster than CPC1 and exhibits superior accuracy compared with CPC1, especially for long non-coding transcripts. Moreover, the model of CPC2 is species-neutral, making it feasible for ever-growing non-model organism transcriptomes. A mobile-friendly web server, as well as a downloadable standalone package, is freely available at http://cpc2.cbi.pku.edu.cn.
© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

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Year:  2017        PMID： 28521017      PMCID： PMC5793834          DOI： 10.1093/nar/gkx428

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


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