Literature DB >> 30622217

The long non-coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis.

Christian Ziegler1, Johannes Graf1, Stefan Faderl1, Jessica Schedlbauer1, Nicholas Strieder2, Bianca Förstl1, Rainer Spang2, Astrid Bruckmann1, Rainer Merkl3, Sonja Hombach1, Markus Kretz4.   

Abstract

Several long non-coding RNAs (lncRNAs) act as regulators of cellular homeostasis; however, few of these molecules were functionally characterized in a mature human tissue environment. Here, we report that the lncRNA LINC00941 is a crucial regulator of human epidermal homeostasis. LINC00941 is enriched in progenitor keratinocytes and acts as a repressor of keratinocyte differentiation. Furthermore, LINC00941 represses SPRR5, a previously uncharacterized molecule, which functions as an essential positive regulator of keratinocyte differentiation. Interestingly, 54.8% of genes repressed in SPRR5-deficient epidermal tissue are induced in LINC00941-depleted organotypic epidermis, suggesting a common mode of action for both molecules.
© 2019 The Authors.

Entities:  

Keywords:  LINC00941; SPRR5; differentiation; epidermis; long non‐coding RNA

Year:  2019        PMID： 30622217      PMCID： PMC6362352          DOI： 10.15252/embr.201846612

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  42 in total

1.  p63 is a p53 homologue required for limb and epidermal morphogenesis.

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Journal:  Nature       Date:  1999-04-22       Impact factor: 49.962

2.  Mesenchymal Stem Cells Promote Hepatocarcinogenesis via lncRNA-MUF Interaction with ANXA2 and miR-34a.

Authors:  Xinlong Yan; Dongdong Zhang; Wei Wu; Shuheng Wu; Jingfeng Qian; Yajing Hao; Fang Yan; Pingping Zhu; Jiayi Wu; Guanling Huang; Yinghui Huang; Jianjun Luo; Xinhui Liu; Benyu Liu; Xiaomin Chen; Ying Du; Runsheng Chen; Zusen Fan
Journal:  Cancer Res       Date:  2017-09-25       Impact factor: 12.701

3.  A LncRNA-MAF:MAFB transcription factor network regulates epidermal differentiation.

Authors:  Vanessa Lopez-Pajares; Kun Qu; Jiajing Zhang; Dan E Webster; Brook C Barajas; Zurab Siprashvili; Brian J Zarnegar; Lisa D Boxer; Eon J Rios; Shiying Tao; Markus Kretz; Paul A Khavari
Journal:  Dev Cell       Date:  2015-03-23       Impact factor: 12.270

Review 4.  Functional Classification and Experimental Dissection of Long Noncoding RNAs.

Authors:  Florian Kopp; Joshua T Mendell
Journal:  Cell       Date:  2018-01-25       Impact factor: 41.582

5.  Control of somatic tissue differentiation by the long non-coding RNA TINCR.

Authors:  Markus Kretz; Zurab Siprashvili; Ci Chu; Dan E Webster; Ashley Zehnder; Kun Qu; Carolyn S Lee; Ross J Flockhart; Abigail F Groff; Jennifer Chow; Danielle Johnston; Grace E Kim; Robert C Spitale; Ryan A Flynn; Grace X Y Zheng; Subhadra Aiyer; Arjun Raj; John L Rinn; Howard Y Chang; Paul A Khavari
Journal:  Nature       Date:  2012-12-02       Impact factor: 49.962

6.  Genes encoding structural proteins of epidermal cornification and S100 calcium-binding proteins form a gene complex ("epidermal differentiation complex") on human chromosome 1q21.

Authors:  D Mischke; B P Korge; I Marenholz; A Volz; A Ziegler
Journal:  J Invest Dermatol       Date:  1996-05       Impact factor: 8.551

7.  NCBI GEO: archive for functional genomics data sets--update.

Authors:  Tanya Barrett; Stephen E Wilhite; Pierre Ledoux; Carlos Evangelista; Irene F Kim; Maxim Tomashevsky; Kimberly A Marshall; Katherine H Phillippy; Patti M Sherman; Michelle Holko; Andrey Yefanov; Hyeseung Lee; Naigong Zhang; Cynthia L Robertson; Nadezhda Serova; Sean Davis; Alexandra Soboleva
Journal:  Nucleic Acids Res       Date:  2012-11-27       Impact factor: 16.971

8.  A novel ATAC-seq approach reveals lineage-specific reinforcement of the open chromatin landscape via cooperation between BAF and p63.

Authors:  Xiaomin Bao; Adam J Rubin; Kun Qu; Jiajing Zhang; Paul G Giresi; Howard Y Chang; Paul A Khavari
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9.  Ensembl 2018.

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Journal:  Nucleic Acids Res       Date:  2018-01-04       Impact factor: 16.971

10.  Massive mining of publicly available RNA-seq data from human and mouse.

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  6 in total

1.  The hepatocyte-specifically expressed lnc-HSER alleviates hepatic fibrosis by inhibiting hepatocyte apoptosis and epithelial-mesenchymal transition.

Authors:  Kun Zhang; Mengxia Zhang; Qingbin Yao; Xiaohui Han; Yanmian Zhao; Lina Zheng; Guantong Li; Qi Liu; Yanan Chang; Peijun Zhang; Hongmei Cui; Zhemin Shi; Ting Chen; Zhi Yao; Tao Han; Wei Hong
Journal:  Theranostics       Date:  2019-10-12       Impact factor: 11.556

2.  Long noncoding RNA LINC00941 promotes pancreatic cancer progression by competitively binding miR-335-5p to regulate ROCK1-mediated LIMK1/Cofilin-1 signaling.

Authors:  Jie Wang; Zhiwei He; Jian Xu; Peng Chen; Jianxin Jiang
Journal:  Cell Death Dis       Date:  2021-01-04       Impact factor: 8.469

3.  LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2.

Authors:  Jie Wang; Zhiwei He; Xinyuan Liu; Jian Xu; Xueyi Jiang; Gang Quan; Jianxin Jiang
Journal:  Cell Death Dis       Date:  2022-08-18       Impact factor: 9.685

4.  Transcriptome wide analysis of long non-coding RNA-associated ceRNA regulatory circuits in psoriasis.

Authors:  Jingxia Lin; Xuefei Li; Fangfei Zhang; Lei Zhu; Yongfeng Chen
Journal:  J Cell Mol Med       Date:  2021-06-02       Impact factor: 5.310

Review 5.  The role of noncoding RNAs in epithelial cancer.

Authors:  Massimiliano Agostini; Carlo Ganini; Eleonora Candi; Gerry Melino
Journal:  Cell Death Discov       Date:  2020-03-12

6.  Long non-coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex.

Authors:  Emanuele Panatta; Anna Maria Lena; Mara Mancini; Artem Smirnov; Alberto Marini; Riccardo Delli Ponti; Teresa Botta-Orfila; Gian Gaetano Tartaglia; Alessandro Mauriello; Xinna Zhang; George A Calin; Gerry Melino; Eleonora Candi
Journal:  EMBO Rep       Date:  2020-02-04       Impact factor: 8.807
  6 in total

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