Sung Wook Chung1, Benjamin P Lewis2, Nigel C Rogasch3, Takashi Saeki2, Richard H Thomson2, Kate E Hoy2, Neil W Bailey3, Paul B Fitzgerald2. 1. Monash Alfred Psychiatry Research Centre, Monash University, Central Clinical School and The Alfred, Melbourne, Australia. Electronic address: sung.chung@monash.edu. 2. Monash Alfred Psychiatry Research Centre, Monash University, Central Clinical School and The Alfred, Melbourne, Australia. 3. Brain and Mental Health Laboratory, School of Psychological Sciences and Monash Biomedical Imaging, Monash Institute of Cognitive and Clinical Neuroscience, Monash University, Melbourne, Australia.
Abstract
OBJECTIVES: To examine the effects of intermittent TBS (iTBS) and continuous TBS (cTBS) on cortical reactivity in the dorsolateral prefrontal cortex. METHODS: 10 healthy participants were stimulated with either iTBS, cTBS or sham at F3 electrode. Single- and paired-pulse TMS and concurrent electroencephalography (EEG) were used to assess change in cortical reactivity and long-interval intracortical inhibition (LICI) via TMS-evoked potentials (TEPs) and TMS-evoked oscillations. RESULTS: Significant increases in N120 amplitudes (p<0.01) were observed following iTBS over prefrontal cortex. Changes in TMS-evoked theta oscillations and LICI of theta oscillations were also observed following iTBS (increase) and cTBS (decrease). Change in LICI of theta oscillations correlated with change in N120 amplitude following TBS (r=-0.670, p=0.001). CONCLUSIONS: This study provides preliminary evidence that TBS produces direct changes in cortical reactivity in the prefrontal cortex. Combining TBS with TMS-EEG may be a useful approach to optimise stimulation paradigms prior to the conduct of clinical trials. SIGNIFICANCE: TBS is able to modulate cortical reactivity and cortical inhibition in the prefrontal cortex.
OBJECTIVES: To examine the effects of intermittent TBS (iTBS) and continuous TBS (cTBS) on cortical reactivity in the dorsolateral prefrontal cortex. METHODS: 10 healthy participants were stimulated with either iTBS, cTBS or sham at F3 electrode. Single- and paired-pulse TMS and concurrent electroencephalography (EEG) were used to assess change in cortical reactivity and long-interval intracortical inhibition (LICI) via TMS-evoked potentials (TEPs) and TMS-evoked oscillations. RESULTS: Significant increases in N120 amplitudes (p<0.01) were observed following iTBS over prefrontal cortex. Changes in TMS-evoked theta oscillations and LICI of theta oscillations were also observed following iTBS (increase) and cTBS (decrease). Change in LICI of theta oscillations correlated with change in N120 amplitude following TBS (r=-0.670, p=0.001). CONCLUSIONS: This study provides preliminary evidence that TBS produces direct changes in cortical reactivity in the prefrontal cortex. Combining TBS with TMS-EEG may be a useful approach to optimise stimulation paradigms prior to the conduct of clinical trials. SIGNIFICANCE: TBS is able to modulate cortical reactivity and cortical inhibition in the prefrontal cortex.
Authors: Sung Wook Chung; Nigel C Rogasch; Kate E Hoy; Caley M Sullivan; Robin F H Cash; Paul B Fitzgerald Journal: Hum Brain Mapp Date: 2017-11-09 Impact factor: 5.038
Authors: Julius Kricheldorff; Katharina Göke; Maximilian Kiebs; Florian H Kasten; Christoph S Herrmann; Karsten Witt; Rene Hurlemann Journal: Brain Sci Date: 2022-07-15
Authors: Sung Wook Chung; Caley M Sullivan; Nigel C Rogasch; Kate E Hoy; Neil W Bailey; Robin F H Cash; Paul B Fitzgerald Journal: Hum Brain Mapp Date: 2018-09-25 Impact factor: 5.038
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