Literature DB >> 28488159

Arbitrariness is not enough: towards a functional approach to the genetic code.

Ľudmila Lacková1, Vladimír Matlach2, Dan Faltýnek2.   

Abstract

Arbitrariness in the genetic code is one of the main reasons for a linguistic approach to molecular biology: the genetic code is usually understood as an arbitrary relation between amino acids and nucleobases. However, from a semiotic point of view, arbitrariness should not be the only condition for definition of a code, consequently it is not completely correct to talk about "code" in this case. Yet we suppose that there exist a code in the process of protein synthesis, but on a higher level than the nucleic bases chains. Semiotically, a code should be always associated with a function and we propose to define the genetic code not only relationally (in basis of relation between nucleobases and amino acids) but also in terms of function (function of a protein as meaning of the code). Even if the functional definition of meaning in the genetic code has been discussed in the field of biosemiotics, its further implications have not been considered. In fact, if the function of a protein represents the meaning of the genetic code (the sign's object), then it is crucial to reconsider the notion of its expression (the sign) as well. In our contribution, we will show that the actual model of the genetic code is not the only possible and we will propose a more appropriate model from a semiotic point of view.

Entities:  

Keywords:  Arbitrariness; Biosemiotics; Genetic code; Protein function; Semiotics

Mesh:

Substances:

Year:  2017        PMID: 28488159     DOI: 10.1007/s12064-017-0246-1

Source DB:  PubMed          Journal:  Theory Biosci        ISSN: 1431-7613            Impact factor:   1.919


  12 in total

Review 1.  The linguistics of DNA: words, sentences, grammar, phonetics, and semantics.

Authors:  S Ji
Journal:  Ann N Y Acad Sci       Date:  1999-05-18       Impact factor: 5.691

Review 2.  The language of genes.

Authors:  David B Searls
Journal:  Nature       Date:  2002-11-14       Impact factor: 49.962

3.  Gene and genon concept: coding versus regulation. A conceptual and information-theoretic analysis of genetic storage and expression in the light of modern molecular biology.

Authors:  Klaus Scherrer; Jürgen Jost
Journal:  Theory Biosci       Date:  2007-09-22       Impact factor: 1.919

4.  Functional Information: Towards Synthesis of Biosemiotics and Cybernetics.

Authors:  Alexei A Sharov
Journal:  Entropy (Basel)       Date:  2010-04-27       Impact factor: 2.524

5.  Characterization of sequence variations in human histone H1.2 and H1.4 subtypes.

Authors:  Bettina Sarg; Anna Gréen; Peter Söderkvist; Wilfried Helliger; Ingemar Rundquist; Herbert H Lindner
Journal:  FEBS J       Date:  2005-07       Impact factor: 5.542

6.  The origin of the genetic code.

Authors:  F H Crick
Journal:  J Mol Biol       Date:  1968-12       Impact factor: 5.469

Review 7.  Creutzfeldt-Jakob disease.

Authors:  Beata Sikorska; Richard Knight; James W Ironside; Paweł P Liberski
Journal:  Adv Exp Med Biol       Date:  2012       Impact factor: 2.622

8.  Distinct stages of protein evolution as suggested by protein sequence analysis.

Authors:  E N Trifonov; A Kirzhner; V M Kirzhner; I N Berezovsky
Journal:  J Mol Evol       Date:  2001 Oct-Nov       Impact factor: 2.395

9.  Evolution of natural agents: preservation, advance, and emergence of functional information.

Authors:  Alexei A Sharov
Journal:  Biosemiotics       Date:  2016-04       Impact factor: 0.711

10.  'Genetic Coding' Reconsidered: An Analysis of Actual Usage.

Authors:  Ulrich E Stegmann
Journal:  Br J Philos Sci       Date:  2015-03-15       Impact factor: 3.978

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