Literature DB >> 28483954

Genetic and Functional Characterization of blaCTX-M-199, a Novel Tazobactam and Sulbactam Resistance-Encoding Gene Located in a Conjugative mcr-1-Bearing IncI2 Plasmid.

Jiachang Cai1, Qipeng Cheng2,3, Yingbo Shen4, Danxia Gu5, Ying Fang1, Edward Wai-Chi Chan3, Sheng Chen6,3.   

Abstract

We report the genetic and functional characterization of a novel CTX-M-199 β-lactamase, which was encoded by a blaCTX-M-64 variant gene found in a conjugative mcr-1-bearing IncI2 plasmid and exhibited resistance to β-lactamase inhibitors, tazobactam, and sulbactam.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  CTX-M-199; conjugative IncI2 plasmid; enzyme kinetics; function; inhibitor resistance; mcr-1

Mesh：

Substances：

Year:  2017        PMID： 28483954      PMCID： PMC5487609          DOI： 10.1128/AAC.00562-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

Review 1.  IRT and CMT beta-lactamases and inhibitor resistance.

Authors:  R Cantón; M I Morosini; O Martín; O Martín S de la Maza; E Gomez G de la Pedrosa
Journal:  Clin Microbiol Infect       Date:  2008-01       Impact factor: 8.067

2.  In vitro selection of variants resistant to beta-lactams plus beta-lactamase inhibitors in CTX-M beta-lactamases: predicting the in vivo scenario?

Authors:  Aida Ripoll; Fernando Baquero; Angela Novais; Mario J Rodríguez-Domínguez; Maria-Carmen Turrientes; Rafael Cantón; Juan-Carlos Galán
Journal:  Antimicrob Agents Chemother       Date:  2011-07-25       Impact factor: 5.191

3.  Emergence of an inhibitor-resistant beta-lactamase (SHV-10) derived from an SHV-5 variant.

Authors:  E E Prinarakis; V Miriagou; E Tzelepi; M Gazouli; L S Tzouvelekis
Journal:  Antimicrob Agents Chemother       Date:  1997-04       Impact factor: 5.191

4.  Complete Nucleotide Sequence of an IncI2 Plasmid Coharboring blaCTX-M-55 and mcr-1.

Authors:  Jian Sun; Xing-Ping Li; Run-Shi Yang; Liang-Xing Fang; Wei Huo; Shu-Min Li; Peng Jiang; Xiao-Ping Liao; Ya-Hong Liu
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

5.  CTX-M-190, a Novel β-Lactamase Resistant to Tazobactam and Sulbactam, Identified in an Escherichia coli Clinical Isolate.

Authors:  Zhen Shen; Baixing Ding; Yingmin Bi; Shi Wu; Su Xu; Xiaogang Xu; Qinglan Guo; Minggui Wang
Journal:  Antimicrob Agents Chemother       Date:  2016-12-27       Impact factor: 5.191

6.  Plasmid-mediated colistin resistance in Escherichia coli from the Arabian Peninsula.

Authors:  Ágnes Sonnevend; Akela Ghazawi; Manaf Alqahtani; Atef Shibl; Wafa Jamal; Rayhan Hashmey; Tibor Pal
Journal:  Int J Infect Dis       Date:  2016-08-25       Impact factor: 3.623

7.  Emergence of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae Strains in China.

Authors:  Rong Zhang; Dachuan Lin; Edward Wai-Chi Chan; Danxia Gu; Gong-Xiang Chen; Sheng Chen
Journal:  Antimicrob Agents Chemother       Date:  2015-11-16       Impact factor: 5.191

8.  Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital.

Authors:  Jia Chang Cai; Hong Wei Zhou; Rong Zhang; Gong-Xiang Chen
Journal:  Antimicrob Agents Chemother       Date:  2008-03-10       Impact factor: 5.191

9.  Sex and virulence in Escherichia coli: an evolutionary perspective.

Authors:  Thierry Wirth; Daniel Falush; Ruiting Lan; Frances Colles; Patience Mensa; Lothar H Wieler; Helge Karch; Peter R Reeves; Martin C J Maiden; Howard Ochman; Mark Achtman
Journal:  Mol Microbiol       Date:  2006-06       Impact factor: 3.501

10.  The SEED and the Rapid Annotation of microbial genomes using Subsystems Technology (RAST).

Authors:  Ross Overbeek; Robert Olson; Gordon D Pusch; Gary J Olsen; James J Davis; Terry Disz; Robert A Edwards; Svetlana Gerdes; Bruce Parrello; Maulik Shukla; Veronika Vonstein; Alice R Wattam; Fangfang Xia; Rick Stevens
Journal:  Nucleic Acids Res       Date:  2013-11-29       Impact factor: 16.971
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  7 in total

Review 1.  Past and Present Perspectives on β-Lactamases.

Authors:  Karen Bush
Journal:  Antimicrob Agents Chemother       Date:  2018-09-24       Impact factor: 5.191

2.  In Vivo Evolution of CTX-M-215, a Novel Narrow-Spectrum β-Lactamase in an Escherichia coli Clinical Isolate Conferring Resistance to Mecillinam.

Authors:  Minggui Wang; Qinglan Guo; Mengyun Yin; Guoping Hu; Zhen Shen; Chengli Fang; Xuefei Zhang; Dan Li; Yohei Doi; Yu Zhang
Journal:  Antimicrob Agents Chemother       Date:  2020-10-20       Impact factor: 5.191

Review 3.  Epidemiology of β-Lactamase-Producing Pathogens.

Authors:  Karen Bush; Patricia A Bradford
Journal:  Clin Microbiol Rev       Date:  2020-02-26       Impact factor: 26.132

4.  Defining Substrate Specificity in the CTX-M Family: the Role of Asp240 in Ceftazidime Hydrolysis.

Authors:  Barbara Ghiglione; María Margarita Rodríguez; Lucrecia Curto; Florencia Brunetti; Milena Dropa; Robert A Bonomo; Pablo Power; Gabriel Gutkind
Journal:  Antimicrob Agents Chemother       Date:  2018-05-25       Impact factor: 5.191

5.  Redefining the Origin and Evolution of Chromosomally Encoded blaCTX-M/KLU in the Context of a Revised Taxonomy of Genus Kluyvera.

Authors:  María Margarita Rodríguez; Pablo Power; Thierry Naas; Gabriel Gutkind
Journal:  Antimicrob Agents Chemother       Date:  2021-06-17       Impact factor: 5.191

Review 6.  Molecular Mechanisms, Epidemiology, and Clinical Importance of β-Lactam Resistance in Enterobacteriaceae.

Authors:  Giulia De Angelis; Paola Del Giacomo; Brunella Posteraro; Maurizio Sanguinetti; Mario Tumbarello
Journal:  Int J Mol Sci       Date:  2020-07-18       Impact factor: 5.923

7.  Fecal Carriage and Genetic Characterization of CTX-M-1/9/1-Producing Escherichia coli From Healthy Humans in Hangzhou, China.

Authors:  Jiawei Chen; Sheng Chen; Yin Jiang; Rong Zhang; Jiachang Cai
Journal:  Front Microbiol       Date:  2021-02-16       Impact factor: 5.640
  7 in total

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