Literature DB >> 9087500

Emergence of an inhibitor-resistant beta-lactamase (SHV-10) derived from an SHV-5 variant.

E E Prinarakis1, V Miriagou, E Tzelepi, M Gazouli, L S Tzouvelekis.   

Abstract

An inhibitor-resistant beta-lactamase (SHV-10), derived from an SHV-5 variant (SHV-9), was found in an Escherichia coli clinical isolate. In SHV-10, Ser-130 was replaced by Gly. The enzyme partially retained its ability to hydrolyze penicillins, but its activity against cephalosporins was drastically reduced. A Ser-130-->Gly mutant of the prototype SHV-5, obtained by site-directed mutagenesis, had properties similar to those of SHV-10.

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Year:  1997        PMID： 9087500      PMCID： PMC163805     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

Review 1.  A functional classification scheme for beta-lactamases and its correlation with molecular structure.

Authors:  K Bush; G A Jacoby; A A Medeiros
Journal:  Antimicrob Agents Chemother       Date:  1995-06       Impact factor: 5.191

2.  Characterization of a new TEM-type beta-lactamase resistant to clavulanate, sulbactam, and tazobactam in a clinical isolate of Escherichia coli.

Authors:  J Blazquez; M R Baquero; R Canton; I Alos; F Baquero
Journal:  Antimicrob Agents Chemother       Date:  1993-10       Impact factor: 5.191

3.  Nucleotide sequences of the genes coding for the TEM-like beta-lactamases IRT-1 and IRT-2 (formerly called TRI-1 and TRI-2).

Authors:  A Belaaouaj; C Lapoumeroulie; M M Caniça; G Vedel; P Névot; R Krishnamoorthy; G Paul
Journal:  FEMS Microbiol Lett       Date:  1994-07-01       Impact factor: 2.742

4.  Elucidation of the role of arginine-244 in the turnover processes of class A beta-lactamases.

Authors:  G Zafaralla; E K Manavathu; S A Lerner; S Mobashery
Journal:  Biochemistry       Date:  1992-04-21       Impact factor: 3.162

5.  A structure-based analysis of the inhibition of class A beta-lactamases by sulbactam.

Authors:  U Imtiaz; E M Billings; J R Knox; S Mobashery
Journal:  Biochemistry       Date:  1994-05-17       Impact factor: 3.162

6.  Mechanism of acyl transfer by the class A serine beta-lactamase of Streptomyces albus G.

Authors:  J Lamotte-Brasseur; G Dive; O Dideberg; P Charlier; J M Frère; J M Ghuysen
Journal:  Biochem J       Date:  1991-10-01       Impact factor: 3.857

7.  Clinical isolates of Escherichia coli producing multiple TEM mutants resistant to beta-lactamase inhibitors.

Authors:  D Sirot; C Chanal; C Henquell; R Labia; J Sirot; R Cluzel
Journal:  J Antimicrob Chemother       Date:  1994-06       Impact factor: 5.790

8.  Molecular characterization of nine different types of mutants among 107 inhibitor-resistant TEM beta-lactamases from clinical isolates of Escherichia coli.

Authors:  C Henquell; C Chanal; D Sirot; R Labia; J Sirot
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

9.  Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution.

Authors:  N C Strynadka; H Adachi; S E Jensen; K Johns; A Sielecki; C Betzel; K Sutoh; M N James
Journal:  Nature       Date:  1992-10-22       Impact factor: 49.962

10.  Site-saturation mutagenesis and three-dimensional modelling of ROB-1 define a substrate binding role of Ser130 in class A beta-lactamases.

Authors:  J M Juteau; E Billings; J R Knox; R C Levesque
Journal:  Protein Eng       Date:  1992-10
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  47 in total

1.  Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes.

Authors:  P A Bradford
Journal:  Antimicrob Agents Chemother       Date:  1999-12       Impact factor: 5.191

2.  What's New in beta-lactamases?

Authors:  Patricia A. Bradford
Journal:  Curr Infect Dis Rep       Date:  2001-02       Impact factor: 3.725

3.  BetalasEN: microdilution panel for identifying beta-lactamases present in isolates of Enterobacteriaceae.

Authors:  Christine C Sanders; Anton F Ehrhardt; Ellen Smith Moland; Kenneth S Thomson; Barbara Zimmer; Darcie E Roe
Journal:  J Clin Microbiol       Date:  2002-01       Impact factor: 5.948

4.  TEM-89 beta-lactamase produced by a Proteus mirabilis clinical isolate: new complex mutant (CMT 3) with mutations in both TEM-59 (IRT-17) and TEM-3.

Authors:  C Neuwirth; S Madec; E Siebor; A Pechinot; J M Duez; M Pruneaux; M Fouchereau-Peron; A Kazmierczak; R Labia
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

5.  Mutant TEM beta-lactamase producing resistance to ceftazidime, ampicillins, and beta-lactamase inhibitors.

Authors:  Sergei Vakulenko; Dasantila Golemi
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

Review 6.  Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.

Authors:  P A Bradford
Journal:  Clin Microbiol Rev       Date:  2001-10       Impact factor: 26.132

7.  Prevalence of clinical isolates of Escherichia coli producing inhibitor-resistant beta-lactamases at a University Hospital in Barcelona, Spain, over a 3-year period.

Authors:  Elisenda Miró; Ferran Navarro; Beatriz Mirelis; Montserrat Sabaté; Alba Rivera; Pere Coll; Guillem Prats
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

8.  Effects of Ser130Gly and Asp240Lys substitutions in extended-spectrum beta-lactamase CTX-M-9.

Authors:  C Aumeran; C Chanal; R Labia; D Sirot; J Sirot; R Bonnet
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191

9.  SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae.

Authors:  Véronique Dubois; Laurent Poirel; Corinne Arpin; Laure Coulange; Cécile Bebear; Patrice Nordmann; Claudine Quentin
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

10.  Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) β-lactamase.

Authors:  Marisa L Winkler; Elizabeth A Rodkey; Magdalena A Taracila; Sarah M Drawz; Christopher R Bethel; Krisztina M Papp-Wallace; Kerri M Smith; Yan Xu; Jeffrey R Dwulit-Smith; Chiara Romagnoli; Emilia Caselli; Fabio Prati; Focco van den Akker; Robert A Bonomo
Journal:  J Med Chem       Date:  2013-02-04       Impact factor: 7.446
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