Literature DB >> 32868328

In Vivo Evolution of CTX-M-215, a Novel Narrow-Spectrum β-Lactamase in an Escherichia coli Clinical Isolate Conferring Resistance to Mecillinam.

Minggui Wang1,2, Qinglan Guo1,2, Mengyun Yin3,2, Guoping Hu4, Zhen Shen5, Chengli Fang6,7, Xuefei Zhang3,2, Dan Li3,2, Yohei Doi8, Yu Zhang6,7.   

Abstract

Here, we report a novel narrow-spectrum β-lactamase CTX-M-215 identified in an Escherichia coli clinical isolate in China and conferring high-level resistance to mecillinam but not to cefotaxime. CTX-M-215 differed from CTX-M-125, a CTX-M extended-spectrum β-lactamase (ESBL), by an N132D substitution, which decreased hydrolytic activities toward penicillins and cephalosporins except for mecillinam. High similarity was observed between CTX-M-215- and CTX-M-125-bearing plasmids, carried by different isolates in the same patient, indicating in vivo evolution of CTX-M-215 from CTX-M-125.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  CTX-M-type enzyme; N132D; cefotaxime; mecillinam; narrow-spectrum β-lactamase

Year:  2020        PMID： 32868328      PMCID： PMC7577136          DOI： 10.1128/AAC.00562-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae.

Authors:  Caroline Dallenne; Anaelle Da Costa; Dominique Decré; Christine Favier; Guillaume Arlet
Journal:  J Antimicrob Chemother       Date:  2010-01-12       Impact factor: 5.790

Review 2.  International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases.

Authors:  Kalpana Gupta; Thomas M Hooton; Kurt G Naber; Björn Wullt; Richard Colgan; Loren G Miller; Gregory J Moran; Lindsay E Nicolle; Raul Raz; Anthony J Schaeffer; David E Soper
Journal:  Clin Infect Dis       Date:  2011-03-01       Impact factor: 9.079

3.  Genetic and Functional Characterization of blaCTX-M-199, a Novel Tazobactam and Sulbactam Resistance-Encoding Gene Located in a Conjugative mcr-1-Bearing IncI2 Plasmid.

Authors:  Jiachang Cai; Qipeng Cheng; Yingbo Shen; Danxia Gu; Ying Fang; Edward Wai-Chi Chan; Sheng Chen
Journal:  Antimicrob Agents Chemother       Date:  2017-06-27       Impact factor: 5.191

4.  In vitro activity of mecillinam against Enterobacteriaceae with NDM-1 carbapenemase.

Authors:  Emma C L Marrs; Kathryn M Day; John D Perry
Journal:  J Antimicrob Chemother       Date:  2014-06-10       Impact factor: 5.790

5.  CTX-M-93, a CTX-M variant lacking penicillin hydrolytic activity.

Authors:  Laura Djamdjian; Thierry Naas; Didier Tandé; Gaelle Cuzon; Catherine Hanrotel-Saliou; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2011-02-22       Impact factor: 5.191

6.  CTX-M-190, a Novel β-Lactamase Resistant to Tazobactam and Sulbactam, Identified in an Escherichia coli Clinical Isolate.

Authors:  Zhen Shen; Baixing Ding; Yingmin Bi; Shi Wu; Su Xu; Xiaogang Xu; Qinglan Guo; Minggui Wang
Journal:  Antimicrob Agents Chemother       Date:  2016-12-27       Impact factor: 5.191

Review 7.  A functional classification scheme for beta-lactamases and its correlation with molecular structure.

Authors:  K Bush; G A Jacoby; A A Medeiros
Journal:  Antimicrob Agents Chemother       Date:  1995-06       Impact factor: 5.191

8.  In silico detection and typing of plasmids using PlasmidFinder and plasmid multilocus sequence typing.

Authors:  Alessandra Carattoli; Ea Zankari; Aurora García-Fernández; Mette Voldby Larsen; Ole Lund; Laura Villa; Frank Møller Aarestrup; Henrik Hasman
Journal:  Antimicrob Agents Chemother       Date:  2014-04-28       Impact factor: 5.191

9.  CTX-M-137, a hybrid of CTX-M-14-like and CTX-M-15-like β-lactamases identified in an Escherichia coli clinical isolate.

Authors:  Guo-Bao Tian; Ying-Min Huang; Zhi-Li Fang; Yun Qing; Xue-Fei Zhang; Xi Huang
Journal:  J Antimicrob Chemother       Date:  2014-04-28       Impact factor: 5.790

10.  Mutational change of CTX-M-15 to CTX-M-127 resulting in mecillinam resistant Escherichia coli during pivmecillinam treatment of a patient.

Authors:  Karen Leth Nielsen; Katrine Hartung Hansen; Jesper Boye Nielsen; Jenny Dahl Knudsen; Kristian Schønning; Niels Frimodt-Møller; Frederik Boëtius Hertz; Filip Jansåker
Journal:  Microbiologyopen       Date:  2019-10-01       Impact factor: 3.139
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  2 in total

1.  Activity of mecillinam against carbapenem-resistant Enterobacterales.

Authors:  Cécile Emeraud; Alexandre Godmer; Delphine Girlich; Océane Vanparis; Fériel Mahamdi; Elodie Creton; Agnès B Jousset; Thierry Naas; Rémy A Bonnin; Laurent Dortet
Journal:  J Antimicrob Chemother       Date:  2022-09-30       Impact factor: 5.758

2.  High-Frequency Detection of fosA3 and bla CTX-M-55 Genes in Escherichia coli From Longitudinal Monitoring in Broiler Chicken Farms.

Authors:  Maísa Fabiana Menck-Costa; Ana Angelita Sampaio Baptista; Luiz Eduardo de Souza Gazal; Larissa Justino; Matheus Silva Sanches; Marielen de Souza; Erick Kenji Nishio; Beatriz Queiroz Dos Santos; Victor Dellevedove Cruz; João Vitor Monteiro Berbert; Bruna Carolina Gonçalves; Galdino Andrade; Eliana Carolina Vespero; Gerson Nakazato; Renata Katsuko Takayama Kobayashi
Journal:  Front Microbiol       Date:  2022-05-18       Impact factor: 6.064
  2 in total

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