Literature DB >> 27821452

CTX-M-190, a Novel β-Lactamase Resistant to Tazobactam and Sulbactam, Identified in an Escherichia coli Clinical Isolate.

Zhen Shen1,2, Baixing Ding1,2, Yingmin Bi1,2, Shi Wu1,2, Su Xu1,2, Xiaogang Xu1,2, Qinglan Guo1,2, Minggui Wang3,2.   

Abstract

A novel β-lactamase, CTX-M-190, derived from CTX-M-55 by a single substitution of Ser for Thr at position 133 (Ser133Thr), was identified in a natural Escherichia coli clinical isolate. CTX-M-190 exhibited potent hydrolytic activity against cefotaxime, with a kcat/Km ratio of 14.5 μM-1 s-1, and was highly resistant to inhibition by the β-lactamase inhibitors tazobactam and sulbactam, whose 50% inhibitory concentrations were 77- and 55-fold higher, respectively, for CTX-M-190 than for CTX-M-55. blaCTX-M-190 was located within the genetic platform ISEcp1-blaCTX-M-orf477, which was harbored by a 70-kb IncI1 plasmid.
Copyright © 2016 American Society for Microbiology.

Entities:  

Keywords:  CTX-M-190; Escherichia coli; inhibitor-resistant β-lactamase; sulbactam; tazobactam

Mesh：

Substances：

Year:  2016        PMID： 27821452      PMCID： PMC5192109          DOI： 10.1128/AAC.01848-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

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Journal:  Antimicrob Agents Chemother       Date:  2011-07-25       Impact factor: 5.191

2.  CTX-M-27- and CTX-M-14-producing, ciprofloxacin-resistant Escherichia coli of the H30 subclonal group within ST131 drive a Japanese regional ESBL epidemic.

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4.  Characterization of the Novel CMT Enzyme TEM-154.

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5.  Identification of plasmids by PCR-based replicon typing.

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Review 6.  β-lactam and β-lactamase inhibitor combinations in the treatment of extended-spectrum β-lactamase producing Enterobacteriaceae: time for a reappraisal in the era of few antibiotic options?

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Journal:  Lancet Infect Dis       Date:  2015-02-23       Impact factor: 25.071

7.  CTX-M-137, a hybrid of CTX-M-14-like and CTX-M-15-like β-lactamases identified in an Escherichia coli clinical isolate.

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Review 10.  Epidemiology and genetics of CTX-M extended-spectrum β-lactamases in Gram-negative bacteria.

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Journal:  Crit Rev Microbiol       Date:  2012-06-15       Impact factor: 7.624
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  8 in total

1.  Genetic and Functional Characterization of blaCTX-M-199, a Novel Tazobactam and Sulbactam Resistance-Encoding Gene Located in a Conjugative mcr-1-Bearing IncI2 Plasmid.

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Journal:  Antimicrob Agents Chemother       Date:  2017-06-27       Impact factor: 5.191

Review 2.  Past and Present Perspectives on β-Lactamases.

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Journal:  Antimicrob Agents Chemother       Date:  2018-09-24       Impact factor: 5.191

3.  In Vivo Evolution of CTX-M-215, a Novel Narrow-Spectrum β-Lactamase in an Escherichia coli Clinical Isolate Conferring Resistance to Mecillinam.

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Journal:  Antimicrob Agents Chemother       Date:  2020-10-20       Impact factor: 5.191

4.  Defining Substrate Specificity in the CTX-M Family: the Role of Asp240 in Ceftazidime Hydrolysis.

Authors:  Barbara Ghiglione; María Margarita Rodríguez; Lucrecia Curto; Florencia Brunetti; Milena Dropa; Robert A Bonomo; Pablo Power; Gabriel Gutkind
Journal:  Antimicrob Agents Chemother       Date:  2018-05-25       Impact factor: 5.191

Review 5.  Molecular Mechanisms, Epidemiology, and Clinical Importance of β-Lactam Resistance in Enterobacteriaceae.

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6.  Fecal Carriage and Genetic Characterization of CTX-M-1/9/1-Producing Escherichia coli From Healthy Humans in Hangzhou, China.

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7.  Efflux Pump AcrAB Confers Decreased Susceptibility to Piperacillin-Tazobactam and Ceftolozane-Tazobactam in Tigecycline-Non-Susceptible Klebsiella pneumoniae.

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8.  Reconciling the Potentially Irreconcilable? Genotypic and Phenotypic Amoxicillin-Clavulanate Resistance in Escherichia coli.

Authors:  Timothy J Davies; Nicole Stoesser; Anna E Sheppard; Manal Abuoun; Philip Fowler; Jeremy Swann; T Phuong Quan; David Griffiths; Alison Vaughan; Marcus Morgan; Hang T T Phan; Katie J Jeffery; Monique Andersson; Matt J Ellington; Oskar Ekelund; Neil Woodford; Amy J Mathers; Robert A Bonomo; Derrick W Crook; Tim E A Peto; Muna F Anjum; A Sarah Walker
Journal:  Antimicrob Agents Chemother       Date:  2020-05-21       Impact factor: 5.191
  8 in total

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