| Literature DB >> 28473590 |
Etienne Patin1,2,3, Marie Lopez4,2,3, Rebecca Grollemund5,6, Paul Verdu7, Christine Harmant4,2,3, Hélène Quach4,2,3, Guillaume Laval4,2,3, George H Perry8, Luis B Barreiro9, Alain Froment10, Evelyne Heyer7, Achille Massougbodji11,12, Cesar Fortes-Lima7,13, Florence Migot-Nabias14,15, Gil Bellis16, Jean-Michel Dugoujon13, Joana B Pereira17,18, Verónica Fernandes17,18, Luisa Pereira17,18,19, Lolke Van der Veen20, Patrick Mouguiama-Daouda20,21, Carlos D Bustamante22,23, Jean-Marie Hombert20, Lluís Quintana-Murci1,2,3.
Abstract
Bantu languages are spoken by about 310 million Africans, yet the genetic history of Bantu-speaking populations remains largely unexplored. We generated genomic data for 1318 individuals from 35 populations in western central Africa, where Bantu languages originated. We found that early Bantu speakers first moved southward, through the equatorial rainforest, before spreading toward eastern and southern Africa. We also found that genetic adaptation of Bantu speakers was facilitated by admixture with local populations, particularly for the HLA and LCT loci. Finally, we identified a major contribution of western central African Bantu speakers to the ancestry of African Americans, whose genomes present no strong signals of natural selection. Together, these results highlight the contribution of Bantu-speaking peoples to the complex genetic history of Africans and African Americans.Entities:
Mesh：
Substances：
Year: 2017 PMID： 28473590 DOI： 10.1126/science.aal1988
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728