Literature DB >> 28421434

Estimation of fluorescence lifetime of lipofuscin fluorophores contained in lipofuscin granules of retinal pigment epithelium of human cadaver eyes without signs of pathology.

M A Yakovleva1, T B Feldman2,3, P M Arbukhanova4, S A Borzenok4, V A Kuzmin2, M A Ostrovsky2.   

Abstract

The fluorescence lifetimes of lipofuscin fluorophores contained in chloroform extracts from retinal pigment epithelium (RPE) of human cadaver eyes without signs of pathology were evaluated by single photon counting. The comparison of fluorescence lifetimes of N-retinylidene-N-retinylethanolamine (A2E) and its photooxidation and photodegradation products has been carried out. It was shown that the contribution of A2E to the total fluorescence of chloroform extract from lipofuscin granules is not major. The results are important for the improvement of noninvasive diagnostic method of degenerative diseases of the retina and RPE-fundus autofluorescence (FAF).

Entities:  

Mesh：

Substances：

Year:  2017        PMID： 28421434     DOI： 10.1134/S1607672917010069

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  12 in total

1.  A simple method for the isolation and purification of total lipides from animal tissues.

Authors:  J FOLCH; M LEES; G H SLOANE STANLEY
Journal:  J Biol Chem       Date:  1957-05       Impact factor: 5.157

2.  Towards metabolic mapping of the human retina.

Authors:  D Schweitzer; S Schenke; M Hammer; F Schweitzer; S Jentsch; E Birckner; W Becker; A Bergmann
Journal:  Microsc Res Tech       Date:  2007-05       Impact factor: 2.769

3.  Fluorescence lifetime imaging ophthalmoscopy in glaucoma.

Authors:  L Ramm; S Jentsch; R Augsten; M Hammer
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2014-10-22       Impact factor: 3.117

Review 4.  The bisretinoids of retinal pigment epithelium.

Authors:  Janet R Sparrow; Emily Gregory-Roberts; Kazunori Yamamoto; Anna Blonska; Shanti Kaligotla Ghosh; Keiko Ueda; Jilin Zhou
Journal:  Prog Retin Eye Res       Date:  2011-12-22       Impact factor: 21.198

Review 5.  Phospholipid meets all-trans-retinal: the making of RPE bisretinoids.

Authors:  Janet R Sparrow; Yalin Wu; Chul Y Kim; Jilin Zhou
Journal:  J Lipid Res       Date:  2009-08-07       Impact factor: 5.922

6.  Detection and study of the products of photooxidation of N-retinylidene-N-retinylethanolamine (A2E), the fluorophore of lipofuscin granules from retinal pigment epithelium of human donor eyes.

Authors:  M A Yakovleva; N L Sakina; A S Kononikhin; T B Feldman; E N Nikolaev; A E Dontsov; M A Ostrovsky
Journal:  Dokl Biochem Biophys       Date:  2006 Jul-Aug       Impact factor: 0.788

7.  Time-resolved autofluorescence imaging of human donor retina tissue from donors with significant extramacular drusen.

Authors:  Dietrich Schweitzer; Elizabeth R Gaillard; James Dillon; Robert F Mullins; Stephen Russell; Birgit Hoffmann; Sven Peters; Martin Hammer; Christoph Biskup
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-06-08       Impact factor: 4.799

8.  Changes in spectral properties and composition of lipofuscin fluorophores from human-retinal-pigment epithelium with age and pathology.

Authors:  Tatiana B Feldman; Marina A Yakovleva; Patimat M Arbukhanova; Sergey A Borzenok; Alexey S Kononikhin; Igor A Popov; Evgeny N Nikolaev; Mikhail A Ostrovsky
Journal:  Anal Bioanal Chem       Date:  2014-12-04       Impact factor: 4.142

9.  Retinal fluorescence lifetime imaging ophthalmoscopy measures depend on the severity of Alzheimer's disease.

Authors:  Susanne Jentsch; Dietrich Schweitzer; Kai-Uwe Schmidtke; Sven Peters; Jens Dawczynski; Karl-Jürgen Bär; Martin Hammer
Journal:  Acta Ophthalmol       Date:  2014-12-07       Impact factor: 3.761

10.  Fluorescence lifetime imaging ophthalmoscopy in type 2 diabetic patients who have no signs of diabetic retinopathy.

Authors:  Dietrich Schweitzer; Lydia Deutsch; Matthias Klemm; Susanne Jentsch; Martin Hammer; Sven Peters; Jens Haueisen; Ulrich A Müller; Jens Dawczynski
Journal:  J Biomed Opt       Date:  2015-06       Impact factor: 3.170
View more
  4 in total

1.  The fluorescence lifetime of lipofuscin granule fluorophores contained in the retinal pigment epithelium cells from human cadaver eyes in normal state and in the case of visualized pathology.

Authors:  M A Yakovleva; T B Feldman; P M Arbukhanova; S A Borzenok; V A Kuzmin; M A Ostrovsky
Journal:  Dokl Biochem Biophys       Date:  2017-07-20       Impact factor: 0.788

2.  Spectral analysis of fundus autofluorescence pattern as a tool to detect early stages of degeneration in the retina and retinal pigment epithelium.

Authors:  Tatiana B Feldman; Marina A Yakovleva; Andrey V Larichev; Patimat M Arbukhanova; Alexandra Sh Radchenko; Sergey A Borzenok; Vladimir A Kuzmin; Mikhail A Ostrovsky
Journal:  Eye (Lond)       Date:  2018-05-22       Impact factor: 3.775

3.  Adaptive optics two-photon excited fluorescence lifetime imaging ophthalmoscopy of photoreceptors and retinal pigment epithelium in the living non-human primate eye.

Authors:  Sarah Walters; James A Feeks; Khang T Huynh; Jennifer J Hunter
Journal:  Biomed Opt Express       Date:  2021-12-17       Impact factor: 3.562

4.  Fluorescence Lifetime Imaging Ophthalmoscopy of the Retinal Pigment Epithelium During Wound Healing After Laser Irradiation.

Authors:  Alessa Hutfilz; Svenja Rebecca Sonntag; Britta Lewke; Dirk Theisen-Kunde; Salvatore Grisanti; Ralf Brinkmann; Yoko Miura
Journal:  Transl Vis Sci Technol       Date:  2019-09-18       Impact factor: 3.283
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.