| Literature DB >> 28416818 |
Ingrid E Christophersen1,2,3, Michiel Rienstra4, Carolina Roselli1,5,6, Xiaoyan Yin7,8, Bastiaan Geelhoed4, John Barnard9, Honghuang Lin7,8, Dan E Arking10, Albert V Smith11,12, Christine M Albert13,14, Mark Chaffin1, Nathan R Tucker1,2, Molong Li2, Derek Klarin1, Nathan A Bihlmeyer15, Siew-Kee Low16, Peter E Weeke17,18, Martina Müller-Nurasyid5,19,20, J Gustav Smith1,21, Jennifer A Brody22, Maartje N Niemeijer23, Marcus Dörr24,25, Stella Trompet26, Jennifer Huffman27, Stefan Gustafsson28, Claudia Schurmann29,30, Marcus E Kleber31, Leo-Pekka Lyytikäinen32, Ilkka Seppälä32, Rainer Malik33, Andrea R V R Horimoto34, Marco Perez35, Juha Sinisalo36, Stefanie Aeschbacher37,38, Sébastien Thériault39,40, Jie Yao41, Farid Radmanesh1,42, Stefan Weiss25,43, Alexander Teumer25,44, Seung Hoan Choi1, Lu-Chen Weng1,2, Sebastian Clauss2,19,20, Rajat Deo45, Daniel J Rader45, Svati H Shah46, Albert Sun46, Jemma C Hopewell47, Stephanie Debette48,49,50,51, Ganesh Chauhan48,49, Qiong Yang8, Bradford B Worrall52, Guillaume Paré39,40, Yoichiro Kamatani16, Yanick P Hagemeijer4, Niek Verweij4, Joylene E Siland4, Michiaki Kubo53, Jonathan D Smith9, David R Van Wagoner9, Joshua C Bis22, Siegfried Perz54, Bruce M Psaty22,55,56,57,58, Paul M Ridker13,14, Jared W Magnani7,59, Tamara B Harris60, Lenore J Launer60, M Benjamin Shoemaker17, Sandosh Padmanabhan61, Jeffrey Haessler62, Traci M Bartz22,63, Melanie Waldenberger20,54,64, Peter Lichtner65, Marina Arendt66, Jose E Krieger34, Mika Kähönen67, Lorenz Risch68,69, Alfredo J Mansur70, Annette Peters20,54,71, Blair H Smith72, Lars Lind73, Stuart A Scott74, Yingchang Lu29,30, Erwin B Bottinger29,75, Jussi Hernesniemi32,76, Cecilia M Lindgren77, Jorge A Wong78, Jie Huang79, Markku Eskola76, Andrew P Morris77,80, Ian Ford81, Alex P Reiner55,61, Graciela Delgado31, Lin Y Chen82, Yii-Der Ida Chen41, Roopinder K Sandhu83, Man Li84,85, Eric Boerwinkle86, Lewin Eisele66, Lars Lannfelt87, Natalia Rost1,88, Christopher D Anderson1,42, Kent D Taylor41, Archie Campbell89, Patrik K Magnusson90, David Porteous89, Lynne J Hocking91, Efthymia Vlachopoulou92, Nancy L Pedersen90, Kjell Nikus76, Marju Orho-Melander93, Anders Hamsten94, Jan Heeringa23, Joshua C Denny17, Jennifer Kriebel54,64,71, Dawood Darbar95, Christopher Newton-Cheh1,2, Christian Shaffer17, Peter W Macfarlane96, Stefanie Heilmann-Heimbach97,98, Peter Almgren93, Paul L Huang2, Nona Sotoodehnia56, Elsayed Z Soliman99, Andre G Uitterlinden100, Albert Hofman23, Oscar H Franco23, Uwe Völker25,43, Karl-Heinz Jöckel66, Moritz F Sinner19,20, Henry J Lin41, Xiuqing Guo41, Martin Dichgans33,101,102, Erik Ingelsson28,103, Charles Kooperberg62, Olle Melander104, Ruth J F Loos29,30,105, Jari Laurikka106, David Conen37,38,39, Jonathan Rosand1,42, Pim van der Harst4, Marja-Liisa Lokki92, Sekar Kathiresan1, Alexandre Pereira107,108, J Wouter Jukema26,109,110, Caroline Hayward27, Jerome I Rotter41,111, Winfried März112,113, Terho Lehtimäki32, Bruno H Stricker100,114, Mina K Chung9, Stephan B Felix24,25, Vilmundur Gudnason11,12, Alvaro Alonso115, Dan M Roden17, Stefan Kääb19,20, Daniel I Chasman1,13,116, Susan R Heckbert55,56,57, Emelia J Benjamin7,59,117, Toshihiro Tanaka118,119, Kathryn L Lunetta7,8, Steven A Lubitz1,2,120, Patrick T Ellinor1,2,120.
Abstract
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,142 referents; the exome-wide association studies (ExWAS) and rare variant association studies (RVAS) involved 22,346 cases and 132,086 referents. We identified 12 new genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remodeling. Our results nearly double the number of known genetic loci for atrial fibrillation, provide insights into the molecular basis of atrial fibrillation, and may facilitate the identification of new potential targets for drug discovery.Entities:
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Year: 2017 PMID： 28416818 PMCID： PMC5585859 DOI： 10.1038/ng.3843
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 41.307