Honghuang Lin1, Jessica van Setten2, Albert V Smith2, Nathan A Bihlmeyer2, Helen R Warren2, Jennifer A Brody2, Farid Radmanesh2, Leanne Hall2, Niels Grarup2, Martina Müller-Nurasyid2, Thibaud Boutin2, Niek Verweij2, Henry J Lin2, Ruifang Li-Gao2, Marten E van den Berg2, Jonathan Marten2, Stefan Weiss2, Bram P Prins2, Jeffrey Haessler2, Leo-Pekka Lyytikäinen2, Hao Mei2, Tamara B Harris2, Lenore J Launer2, Man Li2, Alvaro Alonso2, Elsayed Z Soliman2, John M Connell2, Paul L Huang2, Lu-Chen Weng2, Heather S Jameson2, William Hucker2, Alan Hanley2, Nathan R Tucker2, Yii-Der Ida Chen2, Joshua C Bis2, Kenneth M Rice2, Colleen M Sitlani2, Jan A Kors2, Zhijun Xie2, Chengping Wen2, Jared W Magnani2, Christopher P Nelson2, Jørgen K Kanters2, Moritz F Sinner2, Konstantin Strauch2, Annette Peters2, Melanie Waldenberger2, Thomas Meitinger2, Jette Bork-Jensen2, Oluf Pedersen2, Allan Linneberg2, Igor Rudan2, Rudolf A de Boer2, Peter van der Meer2, Jie Yao2, Xiuqing Guo2, Kent D Taylor2, Nona Sotoodehnia2, Jerome I Rotter2, Dennis O Mook-Kanamori2, Stella Trompet2, Fernando Rivadeneira2, André Uitterlinden2, Mark Eijgelsheim2, Sandosh Padmanabhan2, Blair H Smith2, Henry Völzke2, Stephan B Felix2, Georg Homuth2, Uwe Völker2, Massimo Mangino2, Timothy D Spector2, Michiel L Bots2, Marco Perez2, Mika Kähönen2, Olli T Raitakari2, Vilmundur Gudnason2, Dan E Arking2, Patricia B Munroe2, Bruce M Psaty2, Cornelia M van Duijn2, Emelia J Benjamin2, Jonathan Rosand2, Nilesh J Samani2, Torben Hansen2, Stefan Kääb2, Ozren Polasek2, Pim van der Harst2, Susan R Heckbert2, J Wouter Jukema2, Bruno H Stricker2, Caroline Hayward2, Marcus Dörr2, Yalda Jamshidi2, Folkert W Asselbergs2, Charles Kooperberg2, Terho Lehtimäki2, James G Wilson2, Patrick T Ellinor2, Steven A Lubitz1, Aaron Isaacs2. 1. Section of Computational Biomedicine (H.L.) and Section of Cardiovascular Medicine (E.J.B.), Department of Medicine, Boston University School of Medicine, MA. National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, MA (H.L., E.J.B.). Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, The Netherlands (J.v.S., F.W.A.). Icelandic Heart Association, Kopavogur (A.V.S., V.G.). Faculty of Medicine, University of Iceland, Reykjavik (A.V.S., V.G.). Predoctoral Training Program in Human Genetics, McKusick-Nathans Institute of Genetic Medicine (N.A.B.) and McKusick-Nathans Institute of Genetic Medicine (D.E.A.), Johns Hopkins University School of Medicine, Baltimore, MD. William Harvey Research Institute (H.R.W., P.B.M.) and NIHR Barts Cardiovascular Research Unit (H.R.W., P.B.M.), Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom. Cardiovascular Health Research Unit, Department of Medicine (J.A.B., J.C.B., C.M.S.), Department of Biostatistics (K.M.R.), Cardiovascular Health Research Unit, Division of Cardiology, Departments of Medicine and Epidemiology (N.S.), Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services (B.M.P.), and Cardiovascular Health Research Unit, Department of Epidemiology (S.R.H.), University of Washington, Seattle. Center for Human Genetic Research (F. Radmanesh, J.R.) and Cardiovascular Research Center (P.L.H., L.-C.W., H.S.J., W.H., A.H., N.R.T., P.T.E., S.A.L.), Massachusetts General Hospital, Boston. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA (L.-C.W., P.T.E., S.A.L.). Department of Cardiovascular Sciences, University of Leicester, United Kingdom (L.H., C.P.N., N.J.S.). NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, United Kingdom (L.H., C.P.N., N.J.S.). The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences (N.G., J.B.-J., O. Pedersen, T.H.), Laboratory of Experimental Cardiology (J.K.K.), and Department of Clinical Medicine, Faculty of Health and Medical Sciences (A.L.), University of Copenhagen, Denmark. Department of Medicine I, University Hospital Munich, Ludwig Maximilian's University Munich, Germany (M.M.-N., M.F.S., S.K.). Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Germany (K.S.). DZHK (German Cardiovascular Research Centre), Partner Site: Munich Heart Alliance, Germany (M.M.-N., M.F.S., A.P., T.M., S.K.). Institute of Genetic Epidemiology (M.M.-N., K.S.), Institute of Epidemiology II (A.P., M.W.), Research Unit of Molecular Epidemiology (M.W.), and Institute of Human Genetics (T.M.), Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine (T.B., J.M., C.H.) and Usher Institute of Population Health Sciences and Informatics (I.R.), University of Edinburgh, United Kingdom. University of Groningen, University Medical Center Groningen, Department of Cardiology, The Netherlands (N.V., R.A.d.B., P.v.d.M., P.v.d.H.). Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA (H.J.L., Y.-D.I.C., J.Y., X.G., K.D.T., J.I.R.). Department of Clinical Epidemiology (R.L.-G., D.O.M.-K.) and Department of Cardiology (S.T., J.W.J.), Leiden University Medical Center, The Netherlands. Department of Medical Informatics (M.E.v.d.B.), Human Genomics Facility (F. Rivadeneira), Human Genotyping Facility (A.U.), and Department of Epidemiology (M.E., B.H. Stricker), Erasmus MC, University Medical Center Rotterdam, The Netherlands. Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Germany (S.W., G.H., U.V.). DZHK (German Cardiovascular Research Centre), Partner Site Greifswald, Germany (S.W., H.V., S.B.F., U.V., M.D.). Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (J.H., C.K.). Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences (L.-P.L., T.L.) and Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences (M.K.), University of Tampere, Finland. Department of Data Science (H.M.) and Physiology and Biophysics (J.G.W.), University of Mississippi Medical Center, Jackson. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD (T.B.H., L.J.L.). Division of Nephrology and Hypertension, Internal Medicine, School of Medicine, University of Utah, Salt Lake City (M.L.). Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (A.A.). Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.). Medical Research Institute (J.M.C.) and Division of Population Health Sciences (B.H. Smith), Ninewells Hospital and Medical School, University of Dundee, United Kingdom. Department of Medical Informatics (J.A.K.) and Genetic Epidemiology Unit, Department of Epidemiology (C.M.v.D.), Erasmus MC, Rotterdam, The Netherlands. TCM Clinical Basis Institute, Zhejiang Chinese Medicine University, Hangzhou, China (Z.X., C.W.). Division of Cardiology, Department of Medicine, UPMC Heart and Vascular Institute, University of Pittsburgh, PA (J.W.M.). German Center for Diabetes Research, Neuherberg, Germany (A.P.). Institute of Human Genetics, Technische Universität München, Germany (T.M.). Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen (A.L.). Department of Clinical Experimental Research, Rigshospitalet, Denmark (A.L.). British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland (S.P.). Institute for Community Medicine (H.V.) and Department of Internal Medicine B (S.B.F., M.D.), University Medicine Greifswald, Germany. Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom (M.M., T.D.S.). Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands (M.L.B.). Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (M.P.). Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, and Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland (O.T.R.). Kaiser Permanente Washington Health Research Institute, Kaiser Foundation Health Plan of Washington, Seattle (B.M.P., S.R.H.). Faculty of Medicine, University of Split, Croatia (O. Polasek). Cardiogenetics Lab, Genetics and Molecular Cell Sciences Research Centre, Cardiovascular and Cell Sciences Institute, St George's, University of London, Cranmer Terrace, United Kingdom (B.P.P., Y.J.). Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, The Netherlands (F.W.A.). Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom (F.W.A.). Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London, United Kingdom; CARIM School for Cardiovascular Diseases, Maastricht Centre for Systems Biology (MaCSBio) and Department of Biochemistry, Maastricht University, The Netherlands (A.I.). hhlin@bu.edu slubitz@mgh.harvard.edu. 2. Section of Computational Biomedicine (H.L.) and Section of Cardiovascular Medicine (E.J.B.), Department of Medicine, Boston University School of Medicine, MA. National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, MA (H.L., E.J.B.). Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, The Netherlands (J.v.S., F.W.A.). Icelandic Heart Association, Kopavogur (A.V.S., V.G.). Faculty of Medicine, University of Iceland, Reykjavik (A.V.S., V.G.). Predoctoral Training Program in Human Genetics, McKusick-Nathans Institute of Genetic Medicine (N.A.B.) and McKusick-Nathans Institute of Genetic Medicine (D.E.A.), Johns Hopkins University School of Medicine, Baltimore, MD. William Harvey Research Institute (H.R.W., P.B.M.) and NIHR Barts Cardiovascular Research Unit (H.R.W., P.B.M.), Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom. Cardiovascular Health Research Unit, Department of Medicine (J.A.B., J.C.B., C.M.S.), Department of Biostatistics (K.M.R.), Cardiovascular Health Research Unit, Division of Cardiology, Departments of Medicine and Epidemiology (N.S.), Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services (B.M.P.), and Cardiovascular Health Research Unit, Department of Epidemiology (S.R.H.), University of Washington, Seattle. Center for Human Genetic Research (F. Radmanesh, J.R.) and Cardiovascular Research Center (P.L.H., L.-C.W., H.S.J., W.H., A.H., N.R.T., P.T.E., S.A.L.), Massachusetts General Hospital, Boston. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA (L.-C.W., P.T.E., S.A.L.). Department of Cardiovascular Sciences, University of Leicester, United Kingdom (L.H., C.P.N., N.J.S.). NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, United Kingdom (L.H., C.P.N., N.J.S.). The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences (N.G., J.B.-J., O. Pedersen, T.H.), Laboratory of Experimental Cardiology (J.K.K.), and Department of Clinical Medicine, Faculty of Health and Medical Sciences (A.L.), University of Copenhagen, Denmark. Department of Medicine I, University Hospital Munich, Ludwig Maximilian's University Munich, Germany (M.M.-N., M.F.S., S.K.). Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Germany (K.S.). DZHK (German Cardiovascular Research Centre), Partner Site: Munich Heart Alliance, Germany (M.M.-N., M.F.S., A.P., T.M., S.K.). Institute of Genetic Epidemiology (M.M.-N., K.S.), Institute of Epidemiology II (A.P., M.W.), Research Unit of Molecular Epidemiology (M.W.), and Institute of Human Genetics (T.M.), Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine (T.B., J.M., C.H.) and Usher Institute of Population Health Sciences and Informatics (I.R.), University of Edinburgh, United Kingdom. University of Groningen, University Medical Center Groningen, Department of Cardiology, The Netherlands (N.V., R.A.d.B., P.v.d.M., P.v.d.H.). Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA (H.J.L., Y.-D.I.C., J.Y., X.G., K.D.T., J.I.R.). Department of Clinical Epidemiology (R.L.-G., D.O.M.-K.) and Department of Cardiology (S.T., J.W.J.), Leiden University Medical Center, The Netherlands. Department of Medical Informatics (M.E.v.d.B.), Human Genomics Facility (F. Rivadeneira), Human Genotyping Facility (A.U.), and Department of Epidemiology (M.E., B.H. Stricker), Erasmus MC, University Medical Center Rotterdam, The Netherlands. Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Germany (S.W., G.H., U.V.). DZHK (German Cardiovascular Research Centre), Partner Site Greifswald, Germany (S.W., H.V., S.B.F., U.V., M.D.). Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (J.H., C.K.). Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences (L.-P.L., T.L.) and Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences (M.K.), University of Tampere, Finland. Department of Data Science (H.M.) and Physiology and Biophysics (J.G.W.), University of Mississippi Medical Center, Jackson. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD (T.B.H., L.J.L.). Division of Nephrology and Hypertension, Internal Medicine, School of Medicine, University of Utah, Salt Lake City (M.L.). Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (A.A.). Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.). Medical Research Institute (J.M.C.) and Division of Population Health Sciences (B.H. Smith), Ninewells Hospital and Medical School, University of Dundee, United Kingdom. Department of Medical Informatics (J.A.K.) and Genetic Epidemiology Unit, Department of Epidemiology (C.M.v.D.), Erasmus MC, Rotterdam, The Netherlands. TCM Clinical Basis Institute, Zhejiang Chinese Medicine University, Hangzhou, China (Z.X., C.W.). Division of Cardiology, Department of Medicine, UPMC Heart and Vascular Institute, University of Pittsburgh, PA (J.W.M.). German Center for Diabetes Research, Neuherberg, Germany (A.P.). Institute of Human Genetics, Technische Universität München, Germany (T.M.). Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen (A.L.). Department of Clinical Experimental Research, Rigshospitalet, Denmark (A.L.). British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland (S.P.). Institute for Community Medicine (H.V.) and Department of Internal Medicine B (S.B.F., M.D.), University Medicine Greifswald, Germany. Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom (M.M., T.D.S.). Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands (M.L.B.). Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (M.P.). Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, and Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland (O.T.R.). Kaiser Permanente Washington Health Research Institute, Kaiser Foundation Health Plan of Washington, Seattle (B.M.P., S.R.H.). Faculty of Medicine, University of Split, Croatia (O. Polasek). Cardiogenetics Lab, Genetics and Molecular Cell Sciences Research Centre, Cardiovascular and Cell Sciences Institute, St George's, University of London, Cranmer Terrace, United Kingdom (B.P.P., Y.J.). Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, The Netherlands (F.W.A.). Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom (F.W.A.). Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London, United Kingdom; CARIM School for Cardiovascular Diseases, Maastricht Centre for Systems Biology (MaCSBio) and Department of Biochemistry, Maastricht University, The Netherlands (A.I.).
Abstract
BACKGROUND: Electrical conduction from the cardiac sinoatrial node to the ventricles is critical for normal heart function. Genome-wide association studies have identified more than a dozen common genetic loci that are associated with PR interval. However, it is unclear whether rare and low-frequency variants also contribute to PR interval heritability. METHODS: We performed large-scale meta-analyses of the PR interval that included 83 367 participants of European ancestry and 9436 of African ancestry. We examined both common and rare variants associated with the PR interval. RESULTS: We identified 31 genetic loci that were significantly associated with PR interval after Bonferroni correction (P<1.2×10-6), including 11 novel loci that have not been reported previously. Many of these loci are involved in heart morphogenesis. In gene-based analysis, we found that multiple rare variants at MYH6 (P=5.9×10-11) and SCN5A (P=1.1×10-7) were associated with PR interval. SCN5A locus also was implicated in the common variant analysis, whereas MYH6 was a novel locus. CONCLUSIONS: We identified common variants at 11 novel loci and rare variants within 2 gene regions that were significantly associated with PR interval. Our findings provide novel insights to the current understanding of atrioventricular conduction, which is critical for cardiac activity and an important determinant of health.
BACKGROUND: Electrical conduction from the cardiac sinoatrial node to the ventricles is critical for normal heart function. Genome-wide association studies have identified more than a dozen common genetic loci that are associated with PR interval. However, it is unclear whether rare and low-frequency variants also contribute to PR interval heritability. METHODS: We performed large-scale meta-analyses of the PR interval that included 83 367 participants of European ancestry and 9436 of African ancestry. We examined both common and rare variants associated with the PR interval. RESULTS: We identified 31 genetic loci that were significantly associated with PR interval after Bonferroni correction (P<1.2×10-6), including 11 novel loci that have not been reported previously. Many of these loci are involved in heart morphogenesis. In gene-based analysis, we found that multiple rare variants at MYH6 (P=5.9×10-11) and SCN5A (P=1.1×10-7) were associated with PR interval. SCN5A locus also was implicated in the common variant analysis, whereas MYH6 was a novel locus. CONCLUSIONS: We identified common variants at 11 novel loci and rare variants within 2 gene regions that were significantly associated with PR interval. Our findings provide novel insights to the current understanding of atrioventricular conduction, which is critical for cardiac activity and an important determinant of health.
Authors: Arie O Verkerk; Carol Ann Remme; Cees A Schumacher; Brendon P Scicluna; Rianne Wolswinkel; Berend de Jonge; Connie R Bezzina; Marieke W Veldkamp Journal: Circ Res Date: 2012-06-20 Impact factor: 17.367
Authors: Rachel M A Ter Bekke; Aaron Isaacs; Andrei Barysenka; Marije B Hoos; Jan D H Jongbloed; Jan C A Hoorntje; Alfons S M Patelski; Apollonia T J M Helderman-van den Enden; Arthur van den Wijngaard; Monika Stoll; Paul G A Volders Journal: Heart Rhythm Date: 2017-08-03 Impact factor: 6.343
Authors: Timothy M Olson; Virginia V Michels; Jeffrey D Ballew; Sandra P Reyna; Margaret L Karst; Kathleen J Herron; Steven C Horton; Richard J Rodeheffer; Jeffrey L Anderson Journal: JAMA Date: 2005-01-26 Impact factor: 56.272
Authors: Anne M Butler; Xiaoyan Yin; Daniel S Evans; Michael A Nalls; Erin N Smith; Toshiko Tanaka; Guo Li; Sarah G Buxbaum; Eric A Whitsel; Alvaro Alonso; Dan E Arking; Emelia J Benjamin; Gerald S Berenson; Josh C Bis; Wei Chen; Rajat Deo; Patrick T Ellinor; Susan R Heckbert; Gerardo Heiss; Wen-Chi Hsueh; Brendan J Keating; Kathleen F Kerr; Yun Li; Marian C Limacher; Yongmei Liu; Steven A Lubitz; Kristin D Marciante; Reena Mehra; Yan A Meng; Anne B Newman; Christopher Newton-Cheh; Kari E North; Cameron D Palmer; Bruce M Psaty; P Miguel Quibrera; Susan Redline; Alex P Reiner; Jerome I Rotter; Renate B Schnabel; Nicholas J Schork; Andrew B Singleton; J Gustav Smith; Elsayed Z Soliman; Sathanur R Srinivasan; Zhu-ming Zhang; Alan B Zonderman; Luigi Ferrucci; Sarah S Murray; Michele K Evans; Nona Sotoodehnia; Jared W Magnani; Christy L Avery Journal: Circ Cardiovasc Genet Date: 2012-11-08
Authors: Maximilian G Posch; Stephan Waldmuller; Melanie Müller; Thomas Scheffold; David Fournier; Miguel A Andrade-Navarro; Bernard De Geeter; Sophie Guillaumont; Claire Dauphin; Dany Yousseff; Katharina R Schmitt; Andreas Perrot; Felix Berger; Roland Hetzer; Patrice Bouvagnet; Cemil Özcelik Journal: PLoS One Date: 2011-12-14 Impact factor: 3.240
Authors: Musaddeque Ahmed; Richard C Sallari; Haiyang Guo; Jason H Moore; Housheng Hansen He; Mathieu Lupien Journal: BioData Min Date: 2017-02-22 Impact factor: 2.522
Authors: Connie R Bezzina; Julien Barc; Yuka Mizusawa; Carol Ann Remme; Jean-Baptiste Gourraud; Floriane Simonet; Arie O Verkerk; Peter J Schwartz; Lia Crotti; Federica Dagradi; Pascale Guicheney; Véronique Fressart; Antoine Leenhardt; Charles Antzelevitch; Susan Bartkowiak; Martin Borggrefe; Rainer Schimpf; Eric Schulze-Bahr; Sven Zumhagen; Elijah R Behr; Rachel Bastiaenen; Jacob Tfelt-Hansen; Morten Salling Olesen; Stefan Kääb; Britt M Beckmann; Peter Weeke; Hiroshi Watanabe; Naoto Endo; Tohru Minamino; Minoru Horie; Seiko Ohno; Kanae Hasegawa; Naomasa Makita; Akihiko Nogami; Wataru Shimizu; Takeshi Aiba; Philippe Froguel; Beverley Balkau; Olivier Lantieri; Margherita Torchio; Cornelia Wiese; David Weber; Rianne Wolswinkel; Ruben Coronel; Bas J Boukens; Stéphane Bézieau; Eric Charpentier; Stéphanie Chatel; Aurore Despres; Françoise Gros; Florence Kyndt; Simon Lecointe; Pierre Lindenbaum; Vincent Portero; Jade Violleau; Manfred Gessler; Hanno L Tan; Dan M Roden; Vincent M Christoffels; Hervé Le Marec; Arthur A Wilde; Vincent Probst; Jean-Jacques Schott; Christian Dina; Richard Redon Journal: Nat Genet Date: 2013-07-21 Impact factor: 38.330
Authors: Shadi Ahmadmehrabi; Binglan Li; Joseph Park; Batsal Devkota; Marijana Vujkovic; Yi-An Ko; David Van Wagoner; W H Wilson Tang; Ian Krantz; Marylyn Ritchie; Jason Brant; Michael J Ruckenstein; Douglas J Epstein; Daniel J Rader Journal: Hum Genet Date: 2021-03-21 Impact factor: 4.132
Authors: Lu-Chen Weng; Amelia Weber Hall; Seung Hoan Choi; Sean J Jurgens; Jeffrey Haessler; Nathan A Bihlmeyer; Niels Grarup; Honghuang Lin; Alexander Teumer; Ruifang Li-Gao; Jie Yao; Xiuqing Guo; Jennifer A Brody; Martina Müller-Nurasyid; Katharina Schramm; Niek Verweij; Marten E van den Berg; Jessica van Setten; Aaron Isaacs; Julia Ramírez; Helen R Warren; Sandosh Padmanabhan; Jan A Kors; Rudolf A de Boer; Peter van der Meer; Moritz F Sinner; Melanie Waldenberger; Bruce M Psaty; Kent D Taylor; Uwe Völker; Jørgen K Kanters; Man Li; Alvaro Alonso; Marco V Perez; Ilonca Vaartjes; Michiel L Bots; Paul L Huang; Susan R Heckbert; Henry J Lin; Jelena Kornej; Patricia B Munroe; Cornelia M van Duijn; Folkert W Asselbergs; Bruno H Stricker; Pim van der Harst; Stefan Kääb; Annette Peters; Nona Sotoodehnia; Jerome I Rotter; Dennis O Mook-Kanamori; Marcus Dörr; Stephan B Felix; Allan Linneberg; Torben Hansen; Dan E Arking; Charles Kooperberg; Emelia J Benjamin; Kathryn L Lunetta; Patrick T Ellinor; Steven A Lubitz Journal: Circ Genom Precis Med Date: 2020-08-21
Authors: Charlotte Glinge; Najim Lahrouchi; Reza Jabbari; Jacob Tfelt-Hansen; Connie R Bezzina Journal: Cardiovasc Res Date: 2020-07-15 Impact factor: 10.787
Authors: Jessica van Setten; Niek Verweij; Hamdi Mbarek; Maartje N Niemeijer; Stella Trompet; Dan E Arking; Jennifer A Brody; Ilaria Gandin; Niels Grarup; Leanne M Hall; Daiane Hemerich; Leo-Pekka Lyytikäinen; Hao Mei; Martina Müller-Nurasyid; Bram P Prins; Antonietta Robino; Albert V Smith; Helen R Warren; Folkert W Asselbergs; Dorret I Boomsma; Mark J Caulfield; Mark Eijgelsheim; Ian Ford; Torben Hansen; Tamara B Harris; Susan R Heckbert; Jouke-Jan Hottenga; Annamaria Iorio; Jan A Kors; Allan Linneberg; Peter W MacFarlane; Thomas Meitinger; Christopher P Nelson; Olli T Raitakari; Claudia T Silva Aldana; Gianfranco Sinagra; Moritz Sinner; Elsayed Z Soliman; Monika Stoll; Andre Uitterlinden; Cornelia M van Duijn; Melanie Waldenberger; Alvaro Alonso; Paolo Gasparini; Vilmundur Gudnason; Yalda Jamshidi; Stefan Kääb; Jørgen K Kanters; Terho Lehtimäki; Patricia B Munroe; Annette Peters; Nilesh J Samani; Nona Sotoodehnia; Sheila Ulivi; James G Wilson; Eco J C de Geus; J Wouter Jukema; Bruno Stricker; Pim van der Harst; Paul I W de Bakker; Aaron Isaacs Journal: Eur J Hum Genet Date: 2019-01-24 Impact factor: 4.246
Authors: Seung Hoan Choi; Sean J Jurgens; Christopher M Haggerty; Amelia W Hall; Jennifer L Halford; Valerie N Morrill; Lu-Chen Weng; Braxton Lagerman; Tooraj Mirshahi; Mary Pettinger; Xiuqing Guo; Henry J Lin; Alvaro Alonso; Elsayed Z Soliman; Jelena Kornej; Honghuang Lin; Arden Moscati; Girish N Nadkarni; Jennifer A Brody; Kerri L Wiggins; Brian E Cade; Jiwon Lee; Christina Austin-Tse; Tom Blackwell; Mark D Chaffin; Christina J-Y Lee; Heidi L Rehm; Carolina Roselli; Susan Redline; Braxton D Mitchell; Nona Sotoodehnia; Bruce M Psaty; Susan R Heckbert; Ruth J F Loos; Ramachandran S Vasan; Emelia J Benjamin; Adolfo Correa; Eric Boerwinkle; Dan E Arking; Jerome I Rotter; Stephen S Rich; Eric A Whitsel; Marco Perez; Charles Kooperberg; Brandon K Fornwalt; Kathryn L Lunetta; Patrick T Ellinor; Steven A Lubitz Journal: Circ Genom Precis Med Date: 2021-07-28
Authors: Ioanna Ntalla; Lu-Chen Weng; James H Cartwright; Amelia Weber Hall; Gardar Sveinbjornsson; Nathan R Tucker; Seung Hoan Choi; Mark D Chaffin; Carolina Roselli; Michael R Barnes; Borbala Mifsud; Helen R Warren; Caroline Hayward; Jonathan Marten; James J Cranley; Maria Pina Concas; Paolo Gasparini; Thibaud Boutin; Ivana Kolcic; Ozren Polasek; Igor Rudan; Nathalia M Araujo; Maria Fernanda Lima-Costa; Antonio Luiz P Ribeiro; Renan P Souza; Eduardo Tarazona-Santos; Vilmantas Giedraitis; Erik Ingelsson; Anubha Mahajan; Andrew P Morris; Fabiola Del Greco M; Luisa Foco; Martin Gögele; Andrew A Hicks; James P Cook; Lars Lind; Cecilia M Lindgren; Johan Sundström; Christopher P Nelson; Muhammad B Riaz; Nilesh J Samani; Gianfranco Sinagra; Sheila Ulivi; Mika Kähönen; Pashupati P Mishra; Nina Mononen; Kjell Nikus; Mark J Caulfield; Anna Dominiczak; Sandosh Padmanabhan; May E Montasser; Jeff R O'Connell; Kathleen Ryan; Alan R Shuldiner; Stefanie Aeschbacher; David Conen; Lorenz Risch; Sébastien Thériault; Nina Hutri-Kähönen; Terho Lehtimäki; Leo-Pekka Lyytikäinen; Olli T Raitakari; Catriona L K Barnes; Harry Campbell; Peter K Joshi; James F Wilson; Aaron Isaacs; Jan A Kors; Cornelia M van Duijn; Paul L Huang; Vilmundur Gudnason; Tamara B Harris; Lenore J Launer; Albert V Smith; Erwin P Bottinger; Ruth J F Loos; Girish N Nadkarni; Michael H Preuss; Adolfo Correa; Hao Mei; James Wilson; Thomas Meitinger; Martina Müller-Nurasyid; Annette Peters; Melanie Waldenberger; Massimo Mangino; Timothy D Spector; Michiel Rienstra; Yordi J van de Vegte; Pim van der Harst; Niek Verweij; Stefan Kääb; Katharina Schramm; Moritz F Sinner; Konstantin Strauch; Michael J Cutler; Diane Fatkin; Barry London; Morten Olesen; Dan M Roden; M Benjamin Shoemaker; J Gustav Smith; Mary L Biggs; Joshua C Bis; Jennifer A Brody; Bruce M Psaty; Kenneth Rice; Nona Sotoodehnia; Alessandro De Grandi; Christian Fuchsberger; Cristian Pattaro; Peter P Pramstaller; Ian Ford; J Wouter Jukema; Peter W Macfarlane; Stella Trompet; Marcus Dörr; Stephan B Felix; Uwe Völker; Stefan Weiss; Aki S Havulinna; Antti Jula; Katri Sääksjärvi; Veikko Salomaa; Xiuqing Guo; Susan R Heckbert; Henry J Lin; Jerome I Rotter; Kent D Taylor; Jie Yao; Renée de Mutsert; Arie C Maan; Dennis O Mook-Kanamori; Raymond Noordam; Francesco Cucca; Jun Ding; Edward G Lakatta; Yong Qian; Kirill V Tarasov; Daniel Levy; Honghuang Lin; Christopher H Newton-Cheh; Kathryn L Lunetta; Alison D Murray; David J Porteous; Blair H Smith; Bruno H Stricker; André Uitterlinden; Marten E van den Berg; Jeffrey Haessler; Rebecca D Jackson; Charles Kooperberg; Ulrike Peters; Alexander P Reiner; Eric A Whitsel; Alvaro Alonso; Dan E Arking; Eric Boerwinkle; Georg B Ehret; Elsayed Z Soliman; Christy L Avery; Stephanie M Gogarten; Kathleen F Kerr; Cathy C Laurie; Amanda A Seyerle; Adrienne Stilp; Solmaz Assa; M Abdullah Said; M Yldau van der Ende; Pier D Lambiase; Michele Orini; Julia Ramirez; Stefan Van Duijvenboden; David O Arnar; Daniel F Gudbjartsson; Hilma Holm; Patrick Sulem; Gudmar Thorleifsson; Rosa B Thorolfsdottir; Unnur Thorsteinsdottir; Emelia J Benjamin; Andrew Tinker; Kari Stefansson; Patrick T Ellinor; Yalda Jamshidi; Steven A Lubitz; Patricia B Munroe Journal: Nat Commun Date: 2020-05-21 Impact factor: 17.694