Literature DB >> 2841504

Harvey sarcoma virus genome contains no extensive sequences unrelated to those of other retroviruses except ras.

K F Manly1, G R Anderson, D L Stoler.   

Abstract

The Harvey murine sarcoma virus genome contains two rat-derived sets of genetic information recombined with the Moloney mouse leukemia virus. The rat sequences represent a ras oncogene and a rat VL30 element. The VL30 sequences have several discrete regions of similarity with retroviral sequences which were detected by searching a protein database for similarities with predicted polypeptide sequences from the VL30 regions. On the 5' side, the most similar sequences were those of feline sarcoma viruses; on the 3' side, murine leukemia viruses were the most similar. Some of the regions of similarity could also be detected directly by searching a nucleic acid sequence database with the viral DNA sequences. The most extensive region of similarity was that which corresponded to the endonuclease in the pol gene of a murine leukemia virus. The majority of the rat-derived sequences present in the Harvey sarcoma virus genome can now be attributed exclusively to ras or retrovirus- or retrotransposon-related sequences.

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Year:  1988        PMID： 2841504      PMCID： PMC253486          DOI： 10.1128/JVI.62.9.3540-3543.1988

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  26 in total

1.  Rescue of endogenous 30S retroviral sequences from mouse cells by baboon type C virus.

Authors:  S A Sherwin; U R Rapp; R E Benveniste; A Sen; G J Todaro
Journal:  J Virol       Date:  1978-05       Impact factor: 5.103

2.  Heterogeneity of "virus-like" genes encoding retrovirus-associated 30S RNA and their organization within the mouse genome.

Authors:  E Keshet; Y Shaul; J Kaminchik; H Aviv
Journal:  Cell       Date:  1980-06       Impact factor: 41.582

3.  The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes.

Authors:  R W Ellis; D Defeo; T Y Shih; M A Gonda; H A Young; N Tsuchida; D R Lowy; E M Scolnick
Journal:  Nature       Date:  1981-08-06       Impact factor: 49.962

4.  Terminal direct repeats in a retrovirus-like repeated mouse gene family.

Authors:  E Keshet; Y Shaul
Journal:  Nature       Date:  1981-01-01       Impact factor: 49.962

5.  Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus.

Authors:  R Dhar; R W Ellis; T Y Shih; S Oroszlan; B Shapiro; J Maizel; D Lowy; E Scolnick
Journal:  Science       Date:  1982-09-03       Impact factor: 47.728

6.  Rat sequences of the Kirsten and Harvey murine sarcoma virus genomes: nature, origin, and expression in rat tumor RNA.

Authors:  G R Anderson; K C Robbins
Journal:  J Virol       Date:  1976-02       Impact factor: 5.103

7.  Virus-like 30S RNA in mouse cells.

Authors:  P Besmer; U Olshevsky; D Baltimore; D Dolberg; H Fan
Journal:  J Virol       Date:  1979-03       Impact factor: 5.103

8.  The major anoxic stress response protein p34 is a distinct lactate dehydrogenase.

Authors:  G R Anderson; B K Farkas
Journal:  Biochemistry       Date:  1988-03-22       Impact factor: 3.162

9.  Discrete regions of sequence homology between cloned rodent VL30 genetic elements and AKV-related MuLV provirus genomes.

Authors:  C P Giri; C P Hodgson; P K Elder; M G Courtney; M J Getz
Journal:  Nucleic Acids Res       Date:  1983-01-25       Impact factor: 16.971

10.  Mapping of transforming region of the Harvey murine sarcoma virus genome by using insertion-deletion mutants constructed in vitro.

Authors:  C M Wei; D R Lowy; E M Scolnick
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205
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  5 in total

1.  Specificity of retroviral RNA packaging.

Authors:  R Aronoff; M Linial
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103

2.  Characterization of Moloney murine leukemia virus mutants with single-amino-acid substitutions in the Cys-His box of the nucleocapsid protein.

Authors:  C Méric; S P Goff
Journal:  J Virol       Date:  1989-04       Impact factor: 5.103

3.  An internal ribosomal entry signal in the rat VL30 region of the Harvey murine sarcoma virus leader and its use in dicistronic retroviral vectors.

Authors:  C Berlioz; C Torrent; J L Darlix
Journal:  J Virol       Date:  1995-10       Impact factor: 5.103

4.  Anoxia-inducible rat VL30 elements and their relationship to ras-containing sarcoma viruses.

Authors:  B A Firulli; G R Anderson; D L Stoler; S D Estes
Journal:  J Virol       Date:  1993-11       Impact factor: 5.103

5.  Anoxic induction of a sarcoma virus-related VL30 retrotransposon is mediated by a cis-acting element which binds hypoxia-inducible factor 1 and an anoxia-inducible factor.

Authors:  S D Estes; D L Stoler; G R Anderson
Journal:  J Virol       Date:  1995-10       Impact factor: 5.103
  5 in total

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