Literature DB >> 6265801

The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes.

R W Ellis, D Defeo, T Y Shih, M A Gonda, H A Young, N Tsuchida, D R Lowy, E M Scolnick.   

Abstract

The Harvey and Kirsten strains of murine sarcoma virus encode enzymatically and serologically related p21 src proteins which are required for virally mediated cellular transformation. The genes in each virus encoding p21 show such extensive divergence from each other that cloned probes from these genes detect distinct sets of cellular genes in the DNA from several vertebrate species. These data suggest that cellular p21 sarc genes constitute a divergent family of vertebrate genes that can regulate the growth of cells.

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Year:  1981        PMID： 6265801     DOI： 10.1038/292506a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  226 in total

1.  Isolation of transformation suppressor genes by cDNA subtraction: lumican suppresses transformation induced by v-src and v-K-ras.

Authors:  N Yoshioka; H Inoue; K Nakanishi; K Oka; M Yutsudo; A Yamashita; A Hakura; H Nojima
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

2.  Transcription induction of c-Ki-ras with the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in normal and transformed liver cells.

Authors:  S O Chan; S S Wong; D C Yeung
Journal:  Mol Cell Biochem       Date:  1992-11-04       Impact factor: 3.396

3.  A virtual pyrogram generator to resolve complex pyrosequencing results.

Authors:  Guoli Chen; Matthew Theodore Olson; Alan O'Neill; Alexis Norris; Katie Beierl; Shuko Harada; Marija Debeljak; Keila Rivera-Roman; Samantha Finley; Amanda Stafford; Christopher David Gocke; Ming-Tseh Lin; James Richard Eshleman
Journal:  J Mol Diagn       Date:  2012-02-10       Impact factor: 5.568

4.  Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.

Authors:  G T Drivas; A Shih; E Coutavas; M G Rush; P D'Eustachio
Journal:  Mol Cell Biol       Date:  1990-04       Impact factor: 4.272

5.  Resistance to oncogenic transformation in revertant R1 of human ras-transformed NIH 3T3 cells.

Authors:  N Kuzumaki; Y Ogiso; A Oda; H Fujita; H Suzuki; C Sato; L Müllauer
Journal:  Mol Cell Biol       Date:  1989-05       Impact factor: 4.272

6.  The H-ras oncogene product p21 and prognosis in human breast cancer.

Authors:  D M Watson; R A Elton; W J Jack; J M Dixon; U Chetty; W R Miller
Journal:  Breast Cancer Res Treat       Date:  1991 Jan-Feb       Impact factor: 4.872

7.  Development of transforming function during transduction of proto-ras into Harvey sarcoma virus.

Authors:  M Lang; I Treinies; P H Duesberg; R Kurth; K Cichutek
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

8.  Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas.

Authors:  P H Hand; A Thor; D Wunderlich; R Muraro; A Caruso; J Schlom
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

9.  Saccharomyces cerevisiae synthesizes proteins related to the p21 gene product of ras genes found in mammals.

Authors:  A G Papageorge; D Defeo-Jones; P Robinson; G Temeles; E M Scolnick
Journal:  Mol Cell Biol       Date:  1984-01       Impact factor: 4.272

10.  Oncogene overexpression in non-small-cell lung cancer tissue: prevalence and clinicopathological significance.

Authors:  J Lorenz; T Friedberg; R Paulus; F Oesch; R Ferlinz
Journal:  Clin Investig       Date:  1994-01
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