| Literature DB >> 28394885 |
Carolyn E Lubner1, David P Jennings2, David W Mulder1, Gerrit J Schut3, Oleg A Zadvornyy4, John P Hoben5, Monika Tokmina-Lukaszewska4, Luke Berry4, Diep M Nguyen3, Gina L Lipscomb3, Brian Bothner4, Anne K Jones2, Anne-Frances Miller5, Paul W King1, Michael W W Adams3, John W Peters4,6.
Abstract
The recently realized biochemical phenomenon of energy conservation through electron bifurcation provides biology with an elegant means to maximize utilization of metabolic energy. The mechanism of coordinated coupling of exergonic and endergonic oxidation-reduction reactions by a single enzyme complex has been elucidated through optical and paramagnetic spectroscopic studies revealing unprecedented features. Pairs of electrons are bifurcated over more than 1 volt of electrochemical potential by generating a low-potential, highly energetic, unstable flavin semiquinone and directing electron flow to an iron-sulfur cluster with a highly negative potential to overcome the barrier of the endergonic half reaction. The unprecedented range of thermodynamic driving force that is generated by flavin-based electron bifurcation accounts for unique chemical reactions that are catalyzed by these enzymes.Entities:
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Year: 2017 PMID： 28394885 PMCID： PMC7646311 DOI： 10.1038/nchembio.2348
Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040