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Literature DB >> 2837641

The Saccharomyces cerevisiae genome contains functional and nonfunctional copies of transposon Ty1.

J D Boeke¹, D Eichinger, D Castrillon, G R Fink.

Abstract

Saccharomyces cerevisiae Ty elements are transposons closely related to retroviruses. The DNA sequence of a functional Ty element (TyH3) is presented. The long terminal repeat sequences are different, suggesting that TyH3 is a recombinant Ty element. A chromosomal Ty element near the LYS2 gene, Ty173, was found to be nonfunctional, even though it has no detectable insertions or deletions. The defect in Ty173 transposition is caused by a missense mutation giving rise to a Leu-to-Ile substitution in the TYB (pol) open reading frame. Several chromosomal Ty elements carry this lesion in their DNA, indicating that nonfunctional Ty elements are common in the yeast genome.

Entities: Chemical Gene Species

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Year: 1988 PMID： 2837641 PMCID： PMC363300 DOI： 10.1128/mcb.8.4.1432-1442.1988

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

27 in total

Review 1. Structure, replication, and recombination of retrovirus genomes: some unifying hypotheses.

Authors: J M Coffin
Journal: J Gen Virol Date: 1979-01 Impact factor: 3.891

2. Reverse transcriptase activity and Ty RNA are associated with virus-like particles in yeast.

Authors: J Mellor; M H Malim; K Gull; M F Tuite; S McCready; T Dibbayawan; S M Kingsman; A J Kingsman
Journal: Nature Date: 1985 Dec 12-18 Impact factor: 49.962

3. The gapped duplex DNA approach to oligonucleotide-directed mutation construction.

Authors: W Kramer; V Drutsa; H W Jansen; B Kramer; M Pflugfelder; H J Fritz
Journal: Nucleic Acids Res Date: 1984-12-21 Impact factor: 16.971

4. Import of proteins into mitochondria. The precursor of cytochrome c1 is processed in two steps, one of them heme-dependent.

Authors: A Ohashi; J Gibson; I Gregor; G Schatz
Journal: J Biol Chem Date: 1982-11-10 Impact factor: 5.157

5. Reversion of a promoter deletion in yeast.

Authors: S Scherer; C Mann; R W Davis
Journal: Nature Date: 1982-08-26 Impact factor: 49.962

6. New M13 vectors for cloning.

Authors: J Messing
Journal: Methods Enzymol Date: 1983 Impact factor: 1.600

7. Saccharomyces cerevisiae SPT3 gene is required for transposition and transpositional recombination of chromosomal Ty elements.

Authors: J D Boeke; C A Styles; G R Fink
Journal: Mol Cell Biol Date: 1986-11 Impact factor: 4.272

8. Allele-specific hybridization using oligonucleotide probes of very high specific activity: discrimination of the human beta A- and beta S-globin genes.

Authors: A B Studencki; R B Wallace
Journal: DNA Date: 1984

9. DNA sequencing with chain-terminating inhibitors.

Authors: F Sanger; S Nicklen; A R Coulson
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

10. RNA from the yeast transposable element Ty1 has both ends in the direct repeats, a structure similar to retrovirus RNA.

Authors: R T Elder; E Y Loh; R W Davis
Journal: Proc Natl Acad Sci U S A Date: 1983-05 Impact factor: 11.205

80 in total

1. Activation of the Kss1 invasive-filamentous growth pathway induces Ty1 transcription and retrotransposition in Saccharomyces cerevisiae.

Authors: A Morillon; M Springer; P Lesage
Journal: Mol Cell Biol Date: 2000-08 Impact factor: 4.272

2. A nucleocapsid functionality contained within the amino terminus of the Ty1 protease that is distinct and separable from proteolytic activity.

Authors: Joseph F Lawler; Gennady V Merkulov; Jef D Boeke
Journal: J Virol Date: 2002-01 Impact factor: 5.103

The Saccharomyces cerevisiae genome contains functional and nonfunctional copies of transposon Ty1.

Review 1. Structure, replication, and recombination of retrovirus genomes: some unifying hypotheses.

2. Reverse transcriptase activity and Ty RNA are associated with virus-like particles in yeast.

3. The gapped duplex DNA approach to oligonucleotide-directed mutation construction.

4. Import of proteins into mitochondria. The precursor of cytochrome c1 is processed in two steps, one of them heme-dependent.

5. Reversion of a promoter deletion in yeast.

6. New M13 vectors for cloning.

7. Saccharomyces cerevisiae SPT3 gene is required for transposition and transpositional recombination of chromosomal Ty elements.

8. Allele-specific hybridization using oligonucleotide probes of very high specific activity: discrimination of the human beta A- and beta S-globin genes.

9. DNA sequencing with chain-terminating inhibitors.

10. RNA from the yeast transposable element Ty1 has both ends in the direct repeats, a structure similar to retrovirus RNA.

1. Activation of the Kss1 invasive-filamentous growth pathway induces Ty1 transcription and retrotransposition in Saccharomyces cerevisiae.

2. A nucleocapsid functionality contained within the amino terminus of the Ty1 protease that is distinct and separable from proteolytic activity.

3. DNA synthesis fidelity by the reverse transcriptase of the yeast retrotransposon Ty1.

4. DNA damage activates transcription and transposition of yeast Ty retrotransposons.

5. Involvement of cDNA in homologous recombination between Ty elements in Saccharomyces cerevisiae.

6. copia-like retrotransposons are ubiquitous among plants.

7. Ectopic recombination between Ty elements in Saccharomyces cerevisiae is not induced by DNA damage.

8. Ty1-copia group retrotransposons and the evolution of retroelements in the eukaryotes.

9. Post-transcriptional cosuppression of Ty1 retrotransposition.

10. Severe adenine starvation activates Ty1 transcription and retrotransposition in Saccharomyces cerevisiae.