Karoline B Kuchenbaecker1,2, Lesley McGuffog2, Daniel Barrowdale2, Andrew Lee2, Penny Soucy3, Joe Dennis2, Susan M Domchek4, Mark Robson5, Amanda B Spurdle6, Susan J Ramus7, Nasim Mavaddat2, Mary Beth Terry8, Susan L Neuhausen9, Rita Katharina Schmutzler10, Jacques Simard3, Paul D P Pharoah11, Kenneth Offit12, Fergus J Couch13, Georgia Chenevix-Trench6, Douglas F Easton2, Antonis C Antoniou2. 1. The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. 2. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 3. Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Quebec, Canada. 4. Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA. 5. Clinical Genetics, Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 6. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia. 7. School of Women's and Children's Health, University of New South Wales, Australia; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia. 8. Department of Epidemiology, Columbia University, New York, NY, USA. 9. Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA. 10. Center for Hereditary Breast and Ovarian Cancer and Center for Integrated Oncology, Medical Faculty, University Hospital Cologne, Germany. 11. Department of Oncology, University of Cambridge, Cambridge, UK. 12. Clinical Genetics Research Laboratory, Department of Medicine, Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 13. Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Abstract
Background: Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several of these are also associated with risk of BC or OC for women who carry a pathogenic mutation in the high-risk BC and OC genes BRCA1 or BRCA2. The combined effects of these variants on BC or OC risk for BRCA1 and BRCA2 mutation carriers have not yet been assessed while their clinical management could benefit from improved personalized risk estimates. Methods: We constructed polygenic risk scores (PRS) using BC and OC susceptibility SNPs identified through population-based GWAS: for BC (overall, estrogen receptor [ER]-positive, and ER-negative) and for OC. Using data from 15 252 female BRCA1 and 8211 BRCA2 carriers, the association of each PRS with BC or OC risk was evaluated using a weighted cohort approach, with time to diagnosis as the outcome and estimation of the hazard ratios (HRs) per standard deviation increase in the PRS. Results: The PRS for ER-negative BC displayed the strongest association with BC risk in BRCA1 carriers (HR = 1.27, 95% confidence interval [CI] = 1.23 to 1.31, P = 8.2×10 -53 ). In BRCA2 carriers, the strongest association with BC risk was seen for the overall BC PRS (HR = 1.22, 95% CI = 1.17 to 1.28, P = 7.2×10 -20 ). The OC PRS was strongly associated with OC risk for both BRCA1 and BRCA2 carriers. These translate to differences in absolute risks (more than 10% in each case) between the top and bottom deciles of the PRS distribution; for example, the OC risk was 6% by age 80 years for BRCA2 carriers at the 10th percentile of the OC PRS compared with 19% risk for those at the 90th percentile of PRS. Conclusions: BC and OC PRS are predictive of cancer risk in BRCA1 and BRCA2 carriers. Incorporation of the PRS into risk prediction models has promise to better inform decisions on cancer risk management.
Background: Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several of these are also associated with risk of BC or OC for women who carry a pathogenic mutation in the high-risk BC and OC genes BRCA1 or BRCA2. The combined effects of these variants on BC or OC risk for BRCA1 and BRCA2 mutation carriers have not yet been assessed while their clinical management could benefit from improved personalized risk estimates. Methods: We constructed polygenic risk scores (PRS) using BC and OC susceptibility SNPs identified through population-based GWAS: for BC (overall, estrogen receptor [ER]-positive, and ER-negative) and for OC. Using data from 15 252 female BRCA1 and 8211 BRCA2 carriers, the association of each PRS with BC or OC risk was evaluated using a weighted cohort approach, with time to diagnosis as the outcome and estimation of the hazard ratios (HRs) per standard deviation increase in the PRS. Results: The PRS for ER-negative BC displayed the strongest association with BC risk in BRCA1 carriers (HR = 1.27, 95% confidence interval [CI] = 1.23 to 1.31, P = 8.2×10 -53 ). In BRCA2 carriers, the strongest association with BC risk was seen for the overall BC PRS (HR = 1.22, 95% CI = 1.17 to 1.28, P = 7.2×10 -20 ). The OC PRS was strongly associated with OC risk for both BRCA1 and BRCA2 carriers. These translate to differences in absolute risks (more than 10% in each case) between the top and bottom deciles of the PRS distribution; for example, the OC risk was 6% by age 80 years for BRCA2 carriers at the 10th percentile of the OC PRS compared with 19% risk for those at the 90th percentile of PRS. Conclusions: BC and OC PRS are predictive of cancer risk in BRCA1 and BRCA2 carriers. Incorporation of the PRS into risk prediction models has promise to better inform decisions on cancer risk management.
Authors: Antonis C Antoniou; David E Goldgar; Nadine Andrieu; Jenny Chang-Claude; Richard Brohet; Matti A Rookus; Douglas F Easton Journal: Genet Epidemiol Date: 2005-07 Impact factor: 2.135
Authors: Nasim Mavaddat; Susan Peock; Debra Frost; Steve Ellis; Radka Platte; Elena Fineberg; D Gareth Evans; Louise Izatt; Rosalind A Eeles; Julian Adlard; Rosemarie Davidson; Diana Eccles; Trevor Cole; Jackie Cook; Carole Brewer; Marc Tischkowitz; Fiona Douglas; Shirley Hodgson; Lisa Walker; Mary E Porteous; Patrick J Morrison; Lucy E Side; M John Kennedy; Catherine Houghton; Alan Donaldson; Mark T Rogers; Huw Dorkins; Zosia Miedzybrodzka; Helen Gregory; Jacqueline Eason; Julian Barwell; Emma McCann; Alex Murray; Antonis C Antoniou; Douglas F Easton Journal: J Natl Cancer Inst Date: 2013-04-29 Impact factor: 13.506
Authors: Antonis C Antoniou; Jonathan Beesley; Lesley McGuffog; Olga M Sinilnikova; Sue Healey; Susan L Neuhausen; Yuan Chun Ding; Timothy R Rebbeck; Jeffrey N Weitzel; Henry T Lynch; Claudine Isaacs; Patricia A Ganz; Gail Tomlinson; Olufunmilayo I Olopade; Fergus J Couch; Xianshu Wang; Noralane M Lindor; Vernon S Pankratz; Paolo Radice; Siranoush Manoukian; Bernard Peissel; Daniela Zaffaroni; Monica Barile; Alessandra Viel; Anna Allavena; Valentina Dall'Olio; Paolo Peterlongo; Csilla I Szabo; Michal Zikan; Kathleen Claes; Bruce Poppe; Lenka Foretova; Phuong L Mai; Mark H Greene; Gad Rennert; Flavio Lejbkowicz; Gord Glendon; Hilmi Ozcelik; Irene L Andrulis; Mads Thomassen; Anne-Marie Gerdes; Lone Sunde; Dorthe Cruger; Uffe Birk Jensen; Maria Caligo; Eitan Friedman; Bella Kaufman; Yael Laitman; Roni Milgrom; Maya Dubrovsky; Shimrit Cohen; Ake Borg; Helena Jernström; Annika Lindblom; Johanna Rantala; Marie Stenmark-Askmalm; Beatrice Melin; Kate Nathanson; Susan Domchek; Ania Jakubowska; Jan Lubinski; Tomasz Huzarski; Ana Osorio; Adriana Lasa; Mercedes Durán; Maria-Isabel Tejada; Javier Godino; Javier Benitez; Ute Hamann; Mieke Kriege; Nicoline Hoogerbrugge; Rob B van der Luijt; Christi J van Asperen; Peter Devilee; E J Meijers-Heijboer; Marinus J Blok; Cora M Aalfs; Frans Hogervorst; Matti Rookus; Margaret Cook; Clare Oliver; Debra Frost; Don Conroy; D Gareth Evans; Fiona Lalloo; Gabriella Pichert; Rosemarie Davidson; Trevor Cole; Jackie Cook; Joan Paterson; Shirley Hodgson; Patrick J Morrison; Mary E Porteous; Lisa Walker; M John Kennedy; Huw Dorkins; Susan Peock; Andrew K Godwin; Dominique Stoppa-Lyonnet; Antoine de Pauw; Sylvie Mazoyer; Valérie Bonadona; Christine Lasset; Hélène Dreyfus; Dominique Leroux; Agnès Hardouin; Pascaline Berthet; Laurence Faivre; Catherine Loustalot; Tetsuro Noguchi; Hagay Sobol; Etienne Rouleau; Catherine Nogues; Marc Frénay; Laurence Vénat-Bouvet; John L Hopper; Mary B Daly; Mary B Terry; Esther M John; Saundra S Buys; Yosuf Yassin; Alexander Miron; David Goldgar; Christian F Singer; Anne Catharina Dressler; Daphne Gschwantler-Kaulich; Georg Pfeiler; Thomas V O Hansen; Lars Jønson; Bjarni A Agnarsson; Tomas Kirchhoff; Kenneth Offit; Vincent Devlin; Ana Dutra-Clarke; Marion Piedmonte; Gustavo C Rodriguez; Katie Wakeley; John F Boggess; Jack Basil; Peter E Schwartz; Stephanie V Blank; Amanda Ewart Toland; Marco Montagna; Cinzia Casella; Evgeny Imyanitov; Laima Tihomirova; Ignacio Blanco; Conxi Lazaro; Susan J Ramus; Lara Sucheston; Beth Y Karlan; Jenny Gross; Rita Schmutzler; Barbara Wappenschmidt; Christoph Engel; Alfons Meindl; Magdalena Lochmann; Norbert Arnold; Simone Heidemann; Raymonda Varon-Mateeva; Dieter Niederacher; Christian Sutter; Helmut Deissler; Dorothea Gadzicki; Sabine Preisler-Adams; Karin Kast; Ines Schönbuchner; Trinidad Caldes; Miguel de la Hoya; Kristiina Aittomäki; Heli Nevanlinna; Jacques Simard; Amanda B Spurdle; Helene Holland; Xiaoqing Chen; Radka Platte; Georgia Chenevix-Trench; Douglas F Easton Journal: Cancer Res Date: 2010-11-30 Impact factor: 12.701
Authors: Cathleen M Rivera; Brandon R Grossardt; Deborah J Rhodes; Robert D Brown; Véronique L Roger; L Joseph Melton; Walter A Rocca Journal: Menopause Date: 2009 Jan-Feb Impact factor: 2.953
Authors: Fergus J Couch; Xianshu Wang; Lesley McGuffog; Andrew Lee; Curtis Olswold; Karoline B Kuchenbaecker; Penny Soucy; Zachary Fredericksen; Daniel Barrowdale; Joe Dennis; Mia M Gaudet; Ed Dicks; Matthew Kosel; Sue Healey; Olga M Sinilnikova; Adam Lee; François Bacot; Daniel Vincent; Frans B L Hogervorst; Susan Peock; Dominique Stoppa-Lyonnet; Anna Jakubowska; Paolo Radice; Rita Katharina Schmutzler; Susan M Domchek; Marion Piedmonte; Christian F Singer; Eitan Friedman; Mads Thomassen; Thomas V O Hansen; Susan L Neuhausen; Csilla I Szabo; Ignacio Blanco; Mark H Greene; Beth Y Karlan; Judy Garber; Catherine M Phelan; Jeffrey N Weitzel; Marco Montagna; Edith Olah; Irene L Andrulis; Andrew K Godwin; Drakoulis Yannoukakos; David E Goldgar; Trinidad Caldes; Heli Nevanlinna; Ana Osorio; Mary Beth Terry; Mary B Daly; Elizabeth J van Rensburg; Ute Hamann; Susan J Ramus; Amanda Ewart Toland; Maria A Caligo; Olufunmilayo I Olopade; Nadine Tung; Kathleen Claes; Mary S Beattie; Melissa C Southey; Evgeny N Imyanitov; Marc Tischkowitz; Ramunas Janavicius; Esther M John; Ava Kwong; Orland Diez; Judith Balmaña; Rosa B Barkardottir; Banu K Arun; Gad Rennert; Soo-Hwang Teo; Patricia A Ganz; Ian Campbell; Annemarie H van der Hout; Carolien H M van Deurzen; Caroline Seynaeve; Encarna B Gómez Garcia; Flora E van Leeuwen; Hanne E J Meijers-Heijboer; Johannes J P Gille; Margreet G E M Ausems; Marinus J Blok; Marjolijn J L Ligtenberg; Matti A Rookus; Peter Devilee; Senno Verhoef; Theo A M van Os; Juul T Wijnen; Debra Frost; Steve Ellis; Elena Fineberg; Radka Platte; D Gareth Evans; Louise Izatt; Rosalind A Eeles; Julian Adlard; Diana M Eccles; Jackie Cook; Carole Brewer; Fiona Douglas; Shirley Hodgson; Patrick J Morrison; Lucy E Side; Alan Donaldson; Catherine Houghton; Mark T Rogers; Huw Dorkins; Jacqueline Eason; Helen Gregory; Emma McCann; Alex Murray; Alain Calender; Agnès Hardouin; Pascaline Berthet; Capucine Delnatte; Catherine Nogues; Christine Lasset; Claude Houdayer; Dominique Leroux; Etienne Rouleau; Fabienne Prieur; Francesca Damiola; Hagay Sobol; Isabelle Coupier; Laurence Venat-Bouvet; Laurent Castera; Marion Gauthier-Villars; Mélanie Léoné; Pascal Pujol; Sylvie Mazoyer; Yves-Jean Bignon; Elżbieta Złowocka-Perłowska; Jacek Gronwald; Jan Lubinski; Katarzyna Durda; Katarzyna Jaworska; Tomasz Huzarski; Amanda B Spurdle; Alessandra Viel; Bernard Peissel; Bernardo Bonanni; Giulia Melloni; Laura Ottini; Laura Papi; Liliana Varesco; Maria Grazia Tibiletti; Paolo Peterlongo; Sara Volorio; Siranoush Manoukian; Valeria Pensotti; Norbert Arnold; Christoph Engel; Helmut Deissler; Dorothea Gadzicki; Andrea Gehrig; Karin Kast; Kerstin Rhiem; Alfons Meindl; Dieter Niederacher; Nina Ditsch; Hansjoerg Plendl; Sabine Preisler-Adams; Stefanie Engert; Christian Sutter; Raymonda Varon-Mateeva; Barbara Wappenschmidt; Bernhard H F Weber; Brita Arver; Marie Stenmark-Askmalm; Niklas Loman; Richard Rosenquist; Zakaria Einbeigi; Katherine L Nathanson; Timothy R Rebbeck; Stephanie V Blank; David E Cohn; Gustavo C Rodriguez; Laurie Small; Michael Friedlander; Victoria L Bae-Jump; Anneliese Fink-Retter; Christine Rappaport; Daphne Gschwantler-Kaulich; Georg Pfeiler; Muy-Kheng Tea; Noralane M Lindor; Bella Kaufman; Shani Shimon Paluch; Yael Laitman; Anne-Bine Skytte; Anne-Marie Gerdes; Inge Sokilde Pedersen; Sanne Traasdahl Moeller; Torben A Kruse; Uffe Birk Jensen; Joseph Vijai; Kara Sarrel; Mark Robson; Noah Kauff; Anna Marie Mulligan; Gord Glendon; Hilmi Ozcelik; Bent Ejlertsen; Finn C Nielsen; Lars Jønson; Mette K Andersen; Yuan Chun Ding; Linda Steele; Lenka Foretova; Alex Teulé; Conxi Lazaro; Joan Brunet; Miquel Angel Pujana; Phuong L Mai; Jennifer T Loud; Christine Walsh; Jenny Lester; Sandra Orsulic; Steven A Narod; Josef Herzog; Sharon R Sand; Silvia Tognazzo; Simona Agata; Tibor Vaszko; Joellen Weaver; Alexandra V Stavropoulou; Saundra S Buys; Atocha Romero; Miguel de la Hoya; Kristiina Aittomäki; Taru A Muranen; Mercedes Duran; Wendy K Chung; Adriana Lasa; Cecilia M Dorfling; Alexander Miron; Javier Benitez; Leigha Senter; Dezheng Huo; Salina B Chan; Anna P Sokolenko; Jocelyne Chiquette; Laima Tihomirova; Tara M Friebel; Bjarni A Agnarsson; Karen H Lu; Flavio Lejbkowicz; Paul A James; Per Hall; Alison M Dunning; Daniel Tessier; Julie Cunningham; Susan L Slager; Chen Wang; Steven Hart; Kristen Stevens; Jacques Simard; Tomi Pastinen; Vernon S Pankratz; Kenneth Offit; Douglas F Easton; Georgia Chenevix-Trench; Antonis C Antoniou Journal: PLoS Genet Date: 2013-03-27 Impact factor: 5.917
Authors: Mia M Gaudet; Karoline B Kuchenbaecker; Joseph Vijai; Robert J Klein; Tomas Kirchhoff; Lesley McGuffog; Daniel Barrowdale; Alison M Dunning; Andrew Lee; Joe Dennis; Sue Healey; Ed Dicks; Penny Soucy; Olga M Sinilnikova; Vernon S Pankratz; Xianshu Wang; Ronald C Eldridge; Daniel C Tessier; Daniel Vincent; Francois Bacot; Frans B L Hogervorst; Susan Peock; Dominique Stoppa-Lyonnet; Paolo Peterlongo; Rita K Schmutzler; Katherine L Nathanson; Marion Piedmonte; Christian F Singer; Mads Thomassen; Thomas v O Hansen; Susan L Neuhausen; Ignacio Blanco; Mark H Greene; Judith Garber; Jeffrey N Weitzel; Irene L Andrulis; David E Goldgar; Emma D'Andrea; Trinidad Caldes; Heli Nevanlinna; Ana Osorio; Elizabeth J van Rensburg; Adalgeir Arason; Gad Rennert; Ans M W van den Ouweland; Annemarie H van der Hout; Carolien M Kets; Cora M Aalfs; Juul T Wijnen; Margreet G E M Ausems; Debra Frost; Steve Ellis; Elena Fineberg; Radka Platte; D Gareth Evans; Chris Jacobs; Julian Adlard; Marc Tischkowitz; Mary E Porteous; Francesca Damiola; Lisa Golmard; Laure Barjhoux; Michel Longy; Muriel Belotti; Sandra Fert Ferrer; Sylvie Mazoyer; Amanda B Spurdle; Siranoush Manoukian; Monica Barile; Maurizio Genuardi; Norbert Arnold; Alfons Meindl; Christian Sutter; Barbara Wappenschmidt; Susan M Domchek; Georg Pfeiler; Eitan Friedman; Uffe Birk Jensen; Mark Robson; Sohela Shah; Conxi Lazaro; Phuong L Mai; Javier Benitez; Melissa C Southey; Marjanka K Schmidt; Peter A Fasching; Julian Peto; Manjeet K Humphreys; Qin Wang; Kyriaki Michailidou; Elinor J Sawyer; Barbara Burwinkel; Pascal Guénel; Stig E Bojesen; Roger L Milne; Hermann Brenner; Magdalena Lochmann; Kristiina Aittomäki; Thilo Dörk; Sara Margolin; Arto Mannermaa; Diether Lambrechts; Jenny Chang-Claude; Paolo Radice; Graham G Giles; Christopher A Haiman; Robert Winqvist; Peter Devillee; Montserrat García-Closas; Nils Schoof; Maartje J Hooning; Angela Cox; Paul D P Pharoah; Anna Jakubowska; Nick Orr; Anna González-Neira; Guillermo Pita; M Rosario Alonso; Per Hall; Fergus J Couch; Jacques Simard; David Altshuler; Douglas F Easton; Georgia Chenevix-Trench; Antonis C Antoniou; Kenneth Offit Journal: PLoS Genet Date: 2013-03-27 Impact factor: 5.917
Authors: Nasim Mavaddat; Paul D P Pharoah; Kyriaki Michailidou; Jonathan Tyrer; Mark N Brook; Manjeet K Bolla; Qin Wang; Joe Dennis; Alison M Dunning; Mitul Shah; Robert Luben; Judith Brown; Stig E Bojesen; Børge G Nordestgaard; Sune F Nielsen; Henrik Flyger; Kamila Czene; Hatef Darabi; Mikael Eriksson; Julian Peto; Isabel Dos-Santos-Silva; Frank Dudbridge; Nichola Johnson; Marjanka K Schmidt; Annegien Broeks; Senno Verhoef; Emiel J Rutgers; Anthony Swerdlow; Alan Ashworth; Nick Orr; Minouk J Schoemaker; Jonine Figueroa; Stephen J Chanock; Louise Brinton; Jolanta Lissowska; Fergus J Couch; Janet E Olson; Celine Vachon; Vernon S Pankratz; Diether Lambrechts; Hans Wildiers; Chantal Van Ongeval; Erik van Limbergen; Vessela Kristensen; Grethe Grenaker Alnæs; Silje Nord; Anne-Lise Borresen-Dale; Heli Nevanlinna; Taru A Muranen; Kristiina Aittomäki; Carl Blomqvist; Jenny Chang-Claude; Anja Rudolph; Petra Seibold; Dieter Flesch-Janys; Peter A Fasching; Lothar Haeberle; Arif B Ekici; Matthias W Beckmann; Barbara Burwinkel; Frederik Marme; Andreas Schneeweiss; Christof Sohn; Amy Trentham-Dietz; Polly Newcomb; Linda Titus; Kathleen M Egan; David J Hunter; Sara Lindstrom; Rulla M Tamimi; Peter Kraft; Nazneen Rahman; Clare Turnbull; Anthony Renwick; Sheila Seal; Jingmei Li; Jianjun Liu; Keith Humphreys; Javier Benitez; M Pilar Zamora; Jose Ignacio Arias Perez; Primitiva Menéndez; Anna Jakubowska; Jan Lubinski; Katarzyna Jaworska-Bieniek; Katarzyna Durda; Natalia V Bogdanova; Natalia N Antonenkova; Thilo Dörk; Hoda Anton-Culver; Susan L Neuhausen; Argyrios Ziogas; Leslie Bernstein; Peter Devilee; Robert A E M Tollenaar; Caroline Seynaeve; Christi J van Asperen; Angela Cox; Simon S Cross; Malcolm W R Reed; Elza Khusnutdinova; Marina Bermisheva; Darya Prokofyeva; Zalina Takhirova; Alfons Meindl; Rita K Schmutzler; Christian Sutter; Rongxi Yang; Peter Schürmann; Michael Bremer; Hans Christiansen; Tjoung-Won Park-Simon; Peter Hillemanns; Pascal Guénel; Thérèse Truong; Florence Menegaux; Marie Sanchez; Paolo Radice; Paolo Peterlongo; Siranoush Manoukian; Valeria Pensotti; John L Hopper; Helen Tsimiklis; Carmel Apicella; Melissa C Southey; Hiltrud Brauch; Thomas Brüning; Yon-Dschun Ko; Alice J Sigurdson; Michele M Doody; Ute Hamann; Diana Torres; Hans-Ulrich Ulmer; Asta Försti; Elinor J Sawyer; Ian Tomlinson; Michael J Kerin; Nicola Miller; Irene L Andrulis; Julia A Knight; Gord Glendon; Anna Marie Mulligan; Georgia Chenevix-Trench; Rosemary Balleine; Graham G Giles; Roger L Milne; Catriona McLean; Annika Lindblom; Sara Margolin; Christopher A Haiman; Brian E Henderson; Fredrick Schumacher; Loic Le Marchand; Ursula Eilber; Shan Wang-Gohrke; Maartje J Hooning; Antoinette Hollestelle; Ans M W van den Ouweland; Linetta B Koppert; Jane Carpenter; Christine Clarke; Rodney Scott; Arto Mannermaa; Vesa Kataja; Veli-Matti Kosma; Jaana M Hartikainen; Hermann Brenner; Volker Arndt; Christa Stegmaier; Aida Karina Dieffenbach; Robert Winqvist; Katri Pylkäs; Arja Jukkola-Vuorinen; Mervi Grip; Kenneth Offit; Joseph Vijai; Mark Robson; Rohini Rau-Murthy; Miriam Dwek; Ruth Swann; Katherine Annie Perkins; Mark S Goldberg; France Labrèche; Martine Dumont; Diana M Eccles; William J Tapper; Sajjad Rafiq; Esther M John; Alice S Whittemore; Susan Slager; Drakoulis Yannoukakos; Amanda E Toland; Song Yao; Wei Zheng; Sandra L Halverson; Anna González-Neira; Guillermo Pita; M Rosario Alonso; Nuria Álvarez; Daniel Herrero; Daniel C Tessier; Daniel Vincent; Francois Bacot; Craig Luccarini; Caroline Baynes; Shahana Ahmed; Mel Maranian; Catherine S Healey; Jacques Simard; Per Hall; Douglas F Easton; Montserrat Garcia-Closas Journal: J Natl Cancer Inst Date: 2015-04-08 Impact factor: 13.506
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