| Literature DB >> 28369433 |
Abstract
Bacteria and archaea possess numerous defense systems to combat viral infections and other mobile genetic elements. Uniquely among these, CRISPR-Cas (clustered, regularly interspaced short palindromic repeats-CRISPR associated) provides adaptive genetic interference against foreign nucleic acids. Here we review recent advances on the CRISPR-Cas9 system in Neisseria spp, with a focus on its biological functions in genetic transfer, its mechanistic features that establish new paradigms and its technological applications in eukaryotic genome engineering. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.Entities:
Keywords: CRISPR-Cas9; Neisseria spp; RNA-guided adaptive interference; genome engineering
Mesh:
Year: 2017 PMID: 28369433 PMCID: PMC5406484 DOI: 10.1093/femspd/ftx036
Source DB: PubMed Journal: Pathog Dis ISSN: 2049-632X Impact factor: 3.166