Alessia Gimelli1, Riccardo Liga2, Alberto Clemente1, Gavino Marras1, Annette Kusch1, Paolo Marzullo1,3. 1. Fondazione Toscana G. Monasterio, Pisa, Italy. 2. Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Via Paradisa 2, 56100, Pisa, Italy. riccardo.liga@gmail.com. 3. CNR, Institute of Clinical Physiology, Pisa, Italy.
Abstract
BACKGROUND: Single-photon emission computed-tomography (SPECT) allows the quantification of LV eccentricity index (EI), a measure of cardiac remodeling. We sought to evaluate the feasibility of EI measurement with SPECT myocardial perfusion imaging and its interactions with relevant LV functional and structural parameters. METHODS AND RESULTS: Four-hundred and fifty-six patients underwent myocardial perfusion imaging on a Cadmium-Zinc-Telluride (CZT) camera. The summed rest, stress, and difference scores were calculated. From rest images, the LV end-diastolic (EDV) and end-systolic volumes, ejection fraction (EF), and peak filling rate (PFR) were calculated. In every patient, the EI, ranging from 0 (sphere) to 1 (line), was computed using a dedicated software (QGS/QPS; Cedars-Sinai Medical Center). Three-hundred and thirty-eight/456 (74%) patients showed a normal EF (>50%), while 26% had LV systolic dysfunction. The EI was computed from CZT images with excellent reproducibility (interclass correlation coefficient: 0.99, 95% CI 0.98-0.99). More impaired EI values correlated with the presence of a more abnormal LV perfusion (P < .001), function (EF and PFR, P < .001), and structure (EDV, P < .001). On multivariate analysis, higher EDV (P < .001) and depressed EF (P = .014) values were independent predictors of abnormal EI. CONCLUSIONS: The evaluation of LV eccentricity is feasible on gated CZT images. Abnormal EI associates with significant cardiac structural and functional abnormalities.
BACKGROUND: Single-photon emission computed-tomography (SPECT) allows the quantification of LV eccentricity index (EI), a measure of cardiac remodeling. We sought to evaluate the feasibility of EI measurement with SPECT myocardial perfusion imaging and its interactions with relevant LV functional and structural parameters. METHODS AND RESULTS: Four-hundred and fifty-six patients underwent myocardial perfusion imaging on a Cadmium-Zinc-Telluride (CZT) camera. The summed rest, stress, and difference scores were calculated. From rest images, the LV end-diastolic (EDV) and end-systolic volumes, ejection fraction (EF), and peak filling rate (PFR) were calculated. In every patient, the EI, ranging from 0 (sphere) to 1 (line), was computed using a dedicated software (QGS/QPS; Cedars-Sinai Medical Center). Three-hundred and thirty-eight/456 (74%) patients showed a normal EF (>50%), while 26% had LV systolic dysfunction. The EI was computed from CZT images with excellent reproducibility (interclass correlation coefficient: 0.99, 95% CI 0.98-0.99). More impaired EI values correlated with the presence of a more abnormal LV perfusion (P < .001), function (EF and PFR, P < .001), and structure (EDV, P < .001). On multivariate analysis, higher EDV (P < .001) and depressed EF (P = .014) values were independent predictors of abnormal EI. CONCLUSIONS: The evaluation of LV eccentricity is feasible on gated CZT images. Abnormal EI associates with significant cardiac structural and functional abnormalities.
Authors: Yehoshua C Levine; Jason Matos; Michael A Rosenberg; Warren J Manning; Mark E Josephson; Alfred E Buxton Journal: Heart Rhythm Date: 2015-09-25 Impact factor: 6.343
Authors: Vasileios Kamperidis; Victoria Delgado; Nicolas M van Mieghem; Arie-Pieter Kappetein; Martin B Leon; Jeroen J Bax Journal: Eur J Heart Fail Date: 2016-01-04 Impact factor: 15.534
Authors: Akhil Kapur; Katherine A Latus; Glyn Davies; Rhanju T Dhawan; Sian Eastick; Peter H Jarritt; George Roussakis; Melanie C Young; Constantinos Anagnostopoulos; Jimmy Bomanji; Durval C Costa; Dudley J Pennell; Elizabeth M Prvulovich; Peter J Ell; S Richard Underwood Journal: Eur J Nucl Med Mol Imaging Date: 2002-10-11 Impact factor: 9.236
Authors: Robert J H Miller; Tali Sharir; Yuka Otaki; Heidi Gransar; Joanna X Liang; Andrew J Einstein; Mathews B Fish; Terrence D Ruddy; Philipp A Kaufmann; Albert J Sinusas; Edward J Miller; Timothy M Bateman; Sharmila Dorbala; Marcelo Di Carli; Balaji K Tamarappoo; Damini Dey; Daniel S Berman; Piotr J Slomka Journal: J Nucl Med Date: 2021-03-12 Impact factor: 11.082