Cari M Kitahara1,2,3,4,5, Martha S Linet1,2,3,4,5, Stephen Balter1,2,3,4,5, Donald L Miller1,2,3,4,5, Preetha Rajaraman1,2,3,4,5, Elizabeth K Cahoon1,2,3,4,5, Raquel Velazquez-Kronen1,2,3,4,5, Steven L Simon1,2,3,4,5, Mark P Little1,2,3,4,5, Michele M Doody1,2,3,4,5, Bruce H Alexander1,2,3,4,5, Dale L Preston1,2,3,4,5. 1. 1 Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, 9609 Medical Center Dr, Bethesda, MD 20892. 2. 2 Departments of Radiology and Medicine, Columbia University Medical Center, New York, NY. 3. 3 Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD. 4. 4 Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN. 5. 5 Hirosoft International, Eureka, CA.
Abstract
OBJECTIVE: Childhood exposure to acute, high-dose radiation has consistently been associated with risk of benign and malignant intracranial tumors of the brain and CNS, but data on risks of adulthood exposure to protracted, low-to-moderate doses of radiation are limited. In a large cohort of radiologic technologists, we quantified the association between protracted, low-to-moderate doses of radiation and malignant intracranial tumor mortality. MATERIALS AND METHODS: The study population included 83,655 female and 26,642 male U.S. radiologic technologists who were certified for at least 2 years as of 1982. The cohort was followed from the completion date of the first or second survey (1983-1989 or 1994-1998) to the date of death, loss to follow-up, or December 31, 2012, whichever was earliest. Occupational brain doses through 1997 were based on work history, historical data, and, for most years after the mid 1970s, individual film badge measurements. Radiation-related excess relative risks (ERRs) and 95% CIs were estimated from Poisson regression models adjusted for attained age and sex. RESULTS: Cumulative mean absorbed brain dose was 12 mGy (range, 0-290 mGy). During follow-up (median, 26.7 years), 193 technologists died of a malignant intracranial neoplasm. Based on models incorporating a 5-year lagged cumulative brain dose, cumulative brain dose was not associated with malignant intracranial tumor mortality (overall ERR per 100 mGy, 0.1; 95% CI, < -0.3 to 1.5). No effect modification was observed by sex or birth cohort. CONCLUSION: In this nationwide cohort of radiologic technologists, cumulative occupational radiation exposure to the brain was not associated with malignant intracranial tumor mortality.
OBJECTIVE: Childhood exposure to acute, high-dose radiation has consistently been associated with risk of benign and malignant intracranial tumors of the brain and CNS, but data on risks of adulthood exposure to protracted, low-to-moderate doses of radiation are limited. In a large cohort of radiologic technologists, we quantified the association between protracted, low-to-moderate doses of radiation and malignant intracranial tumor mortality. MATERIALS AND METHODS: The study population included 83,655 female and 26,642 male U.S. radiologic technologists who were certified for at least 2 years as of 1982. The cohort was followed from the completion date of the first or second survey (1983-1989 or 1994-1998) to the date of death, loss to follow-up, or December 31, 2012, whichever was earliest. Occupational brain doses through 1997 were based on work history, historical data, and, for most years after the mid 1970s, individual film badge measurements. Radiation-related excess relative risks (ERRs) and 95% CIs were estimated from Poisson regression models adjusted for attained age and sex. RESULTS: Cumulative mean absorbed brain dose was 12 mGy (range, 0-290 mGy). During follow-up (median, 26.7 years), 193 technologists died of a malignant intracranial neoplasm. Based on models incorporating a 5-year lagged cumulative brain dose, cumulative brain dose was not associated with malignant intracranial tumor mortality (overall ERR per 100 mGy, 0.1; 95% CI, < -0.3 to 1.5). No effect modification was observed by sex or birth cohort. CONCLUSION: In this nationwide cohort of radiologic technologists, cumulative occupational radiation exposure to the brain was not associated with malignant intracranial tumor mortality.
Authors: Michele Morin Doody; D Michal Freedman; Bruce H Alexander; Michael Hauptmann; Jeremy S Miller; R Sowmya Rao; Kiyohiko Mabuchi; Elaine Ron; Alice J Sigurdson; Martha S Linet Journal: Cancer Date: 2006-06-15 Impact factor: 6.860
Authors: Aliki J Taylor; Mark P Little; David L Winter; Elaine Sugden; David W Ellison; Charles A Stiller; Marilyn Stovall; Clare Frobisher; Emma R Lancashire; Raoul C Reulen; Michael M Hawkins Journal: J Clin Oncol Date: 2010-11-15 Impact factor: 44.544
Authors: Mati Rahu; Kaja Rahu; Anssi Auvinen; Mare Tekkel; Aivars Stengrevics; Timo Hakulinen; John D Boice; Peter D Inskip Journal: Int J Cancer Date: 2006-07-01 Impact factor: 7.396
Authors: Mark P Little; Deukwoo Kwon; Kazataka Doi; Steven L Simon; Dale L Preston; Michele M Doody; Terrence Lee; Jeremy S Miller; Diane M Kampa; Parveen Bhatti; James D Tucker; Martha S Linet; Alice J Sigurdson Journal: Radiat Res Date: 2014-06-16 Impact factor: 2.841
Authors: Melissa Z Braganza; Cari M Kitahara; Amy Berrington de González; Peter D Inskip; Kimberly J Johnson; Preetha Rajaraman Journal: Neuro Oncol Date: 2012-09-05 Impact factor: 12.300
Authors: David B Richardson; Elisabeth Cardis; Robert D Daniels; Michael Gillies; Jacqueline A O'Hagan; Ghassan B Hamra; Richard Haylock; Dominique Laurier; Klervi Leuraud; Monika Moissonnier; Mary K Schubauer-Berigan; Isabelle Thierry-Chef; Ausrele Kesminiene Journal: BMJ Date: 2015-10-20
Authors: C R Muirhead; J A O'Hagan; R G E Haylock; M A Phillipson; T Willcock; G L C Berridge; W Zhang Journal: Br J Cancer Date: 2009-01-13 Impact factor: 7.640
Authors: Daphnée Villoing; Cari M Kitahara; Christopher Passmore; Steven L Simon; R Craig Yoder Journal: J Radiol Prot Date: 2018-06-19 Impact factor: 1.394
Authors: Robert D Daniels; Gerald M Kendall; Isabelle Thierry-Chef; Martha S Linet; Harry M Cullings Journal: J Natl Cancer Inst Monogr Date: 2020-07-01
Authors: Amy Berrington de Gonzalez; Robert D Daniels; Elisabeth Cardis; Harry M Cullings; Ethel Gilbert; Michael Hauptmann; Gerald Kendall; Dominique Laurier; Martha S Linet; Mark P Little; Jay H Lubin; Dale L Preston; David B Richardson; Daniel Stram; Isabelle Thierry-Chef; Mary K Schubauer-Berigan Journal: J Natl Cancer Inst Monogr Date: 2020-07-01
Authors: Mary K Schubauer-Berigan; Amy Berrington de Gonzalez; Elisabeth Cardis; Dominique Laurier; Jay H Lubin; Michael Hauptmann; David B Richardson Journal: J Natl Cancer Inst Monogr Date: 2020-07-01
Authors: Robert C Yoder; Lawrence T Dauer; Stephen Balter; John D Boice; Helen A Grogan; Michael T Mumma; Christopher N Passmore; Lawrence N Rothenberg; Richard J Vetter Journal: Int J Radiat Biol Date: 2019-01-09 Impact factor: 3.352