Erwan Donal1,2, Victoria Delgado3, Julien Magne4,5, Chiara Bucciarelli-Ducci6, Christophe Leclercq1,2, Bernard Cosyns7, Marta Sitges8, Thor Edvardsen9, Elif Sade10, Ivan Stankovic11, Eustachio Agricola12, Maurizio Galderisi13, Patrizio Lancellotti14,15, Alfredo Hernandez2, Sven Plein16, Denisa Muraru17, Ehud Schwammenthal18, Gerhard Hindricks19, Bogdan A Popescu20, Gilbert Habib2,21. 1. Cardiology, Rennes University Hospital, INSERM 1414 Clinical Investigation Center, Innovative Technology, 2 Rue Henri Le Guilloux, CHU Pontchaillou, Rennes F-35000, France. 2. LTSI, Université de Rennes-INSERM, UMR 1099, Rennes, France. 3. Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. 4. CHU Limoges, Hôpital Dupuytren, Cardiologie, Limoges, France. 5. INSERM 1094, Faculté de médecine de Limoges, 2, rue Marcland, 87000 Limoges, France. 6. Bristol Heart Institute, Bristol NIHR Cardiovascular Biomedical Research Unity, University of Bristol, Bristol, UK. 7. UZ Brussel-CVHZ, ICMI 1090 Brussels, Belgium. 8. Cardiovascular Institute, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain. 9. Department of Cardiology, Oslo University Hospital and University of Oslo, Norway. 10. Baskent University, Ankara, Turkey. 11. Department of Cardiology, University Clinical Hospital Centre Zemun, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. 12. Cardiothoracic Department, San Raffaele University Hospital, IRCCS, 20132 Milan, Italy. 13. Department of Advanced Biomeducal Sciences, Federico II University Hospital, Naples, Italy. 14. Department of Cardiology, University of Liège Hospital, GIGA Cardiovascular Sciences, Heart Valve Clinic, CHU SartTilman, Liège, Belgium. 15. Gruppo Villa Maria Care and Research, Anthea Hospital, Bari, Italy. 16. Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Cardiovascular and Metabolic Medicine University of Leeds, Clarendon Way, Leeds, UK. 17. Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua 35128, Italy. 18. Tel Aviv University Sheba Medical Center, Tel Hashomer, Israel. 19. Department of Electrophysiology, University of Leipzig-Heart Center, Leipzig, Germany. 20. University of Medicine and Pharmacy "Carol Davila"-Euroecolab, Institute of Cardiovascular Diseases, Bucharest, Romania. 21. Department of Cardiology, Aix-Marseille Université, 13284 Marseille, France.
Abstract
AIMS: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT. METHODS: The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging. We aim to explore if combing the value of cardiac magnetic resonance (CMR) and echocardiography could be beneficial for selecting heart failure patients for CRT in terms of improvement in long-term survival, clinical symptoms, LV function, and volumes. Speckle tracking echocardiography will be used to assess LV dyssynchrony and wasted cardiac work whereas myocardial scar will be assessed with late gadolinium contrast enhanced CMR. All data will be measured in core laboratories. The study will be conducted in European centres with known expertise in both CRT and multimodality cardiac imaging. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT. METHODS: The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging. We aim to explore if combing the value of cardiac magnetic resonance (CMR) and echocardiography could be beneficial for selecting heart failure patients for CRT in terms of improvement in long-term survival, clinical symptoms, LV function, and volumes. Speckle tracking echocardiography will be used to assess LV dyssynchrony and wasted cardiac work whereas myocardial scar will be assessed with late gadolinium contrast enhanced CMR. All data will be measured in core laboratories. The study will be conducted in European centres with known expertise in both CRT and multimodality cardiac imaging. Published on behalf of the European Society of Cardiology. All rights reserved.
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