Literature DB >> 28326787

Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides.

Thomas P Wyche1,2, Antonio C Ruzzini1, Christine Beemelmanns1, Ki Hyun Kim1, Jonathan L Klassen3, Shugeng Cao1, Michael Poulsen3, Tim S Bugni2, Cameron R Currie3, Jon Clardy1.   

Abstract

Three new dentigerumycin analogues are produced by Streptomyces sp. M41, a bacterium isolated from a South African termite, Macrotermes natalensis. The structures of the complex nonribosomal peptide synthetase-polyketide synthase (NRPS/PKS) hybrid compounds were determined by 1D- and 2D-NMR spectroscopy, high-resolution mass spectrometry, and circular dichroism (CD) spectroscopy. Both cyclic and linear peptides are reported, and the genetic organization of the NRPS modules within the biosynthetic gene cluster accounts for the observed structural diversity.

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Year:  2017        PMID： 28326787      PMCID： PMC6013059          DOI： 10.1021/acs.orglett.7b00545

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  18 in total

1.  Piperazimycins: cytotoxic hexadepsipeptides from a marine-derived bacterium of the genus Streptomyces.

Authors:  Eric D Miller; Christopher A Kauffman; Paul R Jensen; William Fenical
Journal:  J Org Chem       Date:  2007-01-19       Impact factor: 4.354

2.  Nonhybrid, finished microbial genome assemblies from long-read SMRT sequencing data.

Authors:  Chen-Shan Chin; David H Alexander; Patrick Marks; Aaron A Klammer; James Drake; Cheryl Heiner; Alicia Clum; Alex Copeland; John Huddleston; Evan E Eichler; Stephen W Turner; Jonas Korlach
Journal:  Nat Methods       Date:  2013-05-05       Impact factor: 28.547

3.  Variable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants.

Authors:  Clarissa S Sit; Antonio C Ruzzini; Ethan B Van Arnam; Timothy R Ramadhar; Cameron R Currie; Jon Clardy
Journal:  Proc Natl Acad Sci U S A       Date:  2015-10-05       Impact factor: 11.205

4.  Natalamycin A, an Ansamycin from a Termite-Associated Streptomyces sp.

Authors:  Ki Hyun Kim; Timothy R Ramadhar; Christine Beemelmanns; Shugeng Cao; Michael Poulsen; Cameron R Currie; Jon Clardy
Journal:  Chem Sci       Date:  2014-11-01       Impact factor: 9.825

5.  Polyoxypeptins A and B Produced by Streptomyces: Apoptosis-Inducing Cyclic Depsipeptides Containing the Novel Amino Acid (2S,3R)-3-Hydroxy-3-methylproline.

Authors:  Kazuo Umezawa; Kumi Nakazawa; Yoko Ikeda; Hiroshi Naganawa; Shinichi Kondo
Journal:  J Org Chem       Date:  1999-04-30       Impact factor: 4.354

6.  Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39.

Authors:  Christine Beemelmanns; Timothy R Ramadhar; Ki Hyun Kim; Jonathan L Klassen; Shugeng Cao; Thomas P Wyche; Yanpeng Hou; Michael Poulsen; Tim S Bugni; Cameron R Currie; Jon Clardy
Journal:  Org Lett       Date:  2017-02-16       Impact factor: 6.005

7.  Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis.

Authors:  Dong-Chan Oh; Michael Poulsen; Cameron R Currie; Jon Clardy
Journal:  Nat Chem Biol       Date:  2009-03-29       Impact factor: 15.040

8.  Real-time DNA sequencing from single polymerase molecules.

Authors:  John Eid; Adrian Fehr; Jeremy Gray; Khai Luong; John Lyle; Geoff Otto; Paul Peluso; David Rank; Primo Baybayan; Brad Bettman; Arkadiusz Bibillo; Keith Bjornson; Bidhan Chaudhuri; Frederick Christians; Ronald Cicero; Sonya Clark; Ravindra Dalal; Alex Dewinter; John Dixon; Mathieu Foquet; Alfred Gaertner; Paul Hardenbol; Cheryl Heiner; Kevin Hester; David Holden; Gregory Kearns; Xiangxu Kong; Ronald Kuse; Yves Lacroix; Steven Lin; Paul Lundquist; Congcong Ma; Patrick Marks; Mark Maxham; Devon Murphy; Insil Park; Thang Pham; Michael Phillips; Joy Roy; Robert Sebra; Gene Shen; Jon Sorenson; Austin Tomaney; Kevin Travers; Mark Trulson; John Vieceli; Jeffrey Wegener; Dawn Wu; Alicia Yang; Denis Zaccarin; Peter Zhao; Frank Zhong; Jonas Korlach; Stephen Turner
Journal:  Science       Date:  2008-11-20       Impact factor: 47.728

9.  Microbial strain prioritization using metabolomics tools for the discovery of natural products.

Authors:  Yanpeng Hou; Doug R Braun; Cole R Michel; Jonathan L Klassen; Navid Adnani; Thomas P Wyche; Tim S Bugni
Journal:  Anal Chem       Date:  2012-05-03       Impact factor: 6.986

10.  A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis.

Authors:  Marnix H Medema; Peter Cimermancic; Andrej Sali; Eriko Takano; Michael A Fischbach
Journal:  PLoS Comput Biol       Date:  2014-12-04       Impact factor: 4.475
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  9 in total

1.  Natural Product Discovery Using Planes of Principal Component Analysis in R (PoPCAR).

Authors:  Shaurya Chanana; Chris S Thomas; Doug R Braun; Yanpeng Hou; Thomas P Wyche; Tim S Bugni
Journal:  Metabolites       Date:  2017-07-13

2.  Coculture of Marine Streptomyces sp. With Bacillus sp. Produces a New Piperazic Acid-Bearing Cyclic Peptide.

Authors:  Daniel Shin; Woong Sub Byun; Kyuho Moon; Yun Kwon; Munhyung Bae; Soohyun Um; Sang Kook Lee; Dong-Chan Oh
Journal:  Front Chem       Date:  2018-10-18       Impact factor: 5.221

3.  Natural Products from Actinobacteria Associated with Fungus-Growing Termites.

Authors:  René Benndorf; Huijuan Guo; Elisabeth Sommerwerk; Christiane Weigel; Maria Garcia-Altares; Karin Martin; Haofu Hu; Michelle Küfner; Z Wilhelm de Beer; Michael Poulsen; Christine Beemelmanns
Journal:  Antibiotics (Basel)       Date:  2018-09-13

4.  hcapca: Automated Hierarchical Clustering and Principal Component Analysis of Large Metabolomic Datasets in R.

Authors:  Shaurya Chanana; Chris S Thomas; Fan Zhang; Scott R Rajski; Tim S Bugni
Journal:  Metabolites       Date:  2020-07-21

Review 5.  Chemical warfare between fungus-growing ants and their pathogens.

Authors:  Sibyl F D Batey; Claudio Greco; Matthew I Hutchings; Barrie Wilkinson
Journal:  Curr Opin Chem Biol       Date:  2020-09-17       Impact factor: 8.822

6.  Epoxinnamide: An Epoxy Cinnamoyl-Containing Nonribosomal Peptide from an Intertidal Mudflat-Derived Streptomyces sp.

Authors:  Sangwook Kang; Jaeho Han; Sung Chul Jang; Joon Soo An; Ilnam Kang; Yun Kwon; Sang-Jip Nam; Sang Hee Shim; Jang-Cheon Cho; Sang Kook Lee; Dong-Chan Oh
Journal:  Mar Drugs       Date:  2022-07-12       Impact factor: 6.085

7.  The Inhibitory Effects of Cyclodepsipeptides from the Entomopathogenic Fungus Beauveria bassiana on Myofibroblast Differentiation in A549 Alveolar Epithelial Cells.

Authors:  Yong Joo Park; Seoung Rak Lee; Dong Min Kim; Jae Sik Yu; Christine Beemelmanns; Kyu Hyuck Chung; Ki Hyun Kim
Journal:  Molecules       Date:  2018-10-08       Impact factor: 4.411

Review 8.  An Overview of Antimicrobial Compounds from African Edible Insects and Their Associated Microbiota.

Authors:  Cynthia M Mudalungu; Chrysantus M Tanga; Segenet Kelemu; Baldwyn Torto
Journal:  Antibiotics (Basel)       Date:  2021-05-22

Review 9.  The chemical ecology of the fungus-farming termite symbiosis.

Authors:  Suzanne Schmidt; Sara Kildgaard; Huijuan Guo; Christine Beemelmanns; Michael Poulsen
Journal:  Nat Prod Rep       Date:  2022-02-23       Impact factor: 13.423
  9 in total

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