Literature DB >> 28207275

Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39.

Christine Beemelmanns1, Timothy R Ramadhar2, Ki Hyun Kim3, Jonathan L Klassen4, Shugeng Cao5, Thomas P Wyche2, Yanpeng Hou, Michael Poulsen6, Tim S Bugni, Cameron R Currie, Jon Clardy2.   

Abstract

Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39's sequenced genome revealed the macrotermycin's putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus and, of greater ecological relevance, they also had selective antifungal activity against a fungal parasite of the termite fungal garden.

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Year:  2017        PMID： 28207275      PMCID： PMC6006516          DOI： 10.1021/acs.orglett.6b03831

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  21 in total

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5.  Mapping Microbial Response Metabolomes for Induced Natural Product Discovery.

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Journal:  ACS Chem Biol       Date:  2015-06-17       Impact factor: 5.100

6.  Vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic.

Authors:  K Shindo; M Kamishohara; A Odagawa; M Matsuoka; H Kawai
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7.  Natalamycin A, an Ansamycin from a Termite-Associated Streptomyces sp.

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Review 8.  Streptomyces as symbionts: an emerging and widespread theme?

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10.  Microbial strain prioritization using metabolomics tools for the discovery of natural products.

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  29 in total

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2.  Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides.

Authors:  Thomas P Wyche; Antonio C Ruzzini; Christine Beemelmanns; Ki Hyun Kim; Jonathan L Klassen; Shugeng Cao; Michael Poulsen; Tim S Bugni; Cameron R Currie; Jon Clardy
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Review 6.  The secondary metabolites of rare actinomycetes: chemistry and bioactivity.

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Journal:  RSC Adv       Date:  2019-07-16       Impact factor: 4.036

7.  Chemical Characterization of a Renoprotective Metabolite from Termite-Associated Streptomyces sp. RB1 against Cisplatin-Induced Cytotoxicity.

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8.  Comparative Genomics and Biosynthetic Potential Analysis of Two Lichen-Isolated Amycolatopsis Strains.

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9.  Comparative genomics reveals phylogenetic distribution patterns of secondary metabolites in Amycolatopsis species.

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10.  Identification of a biosynthetic gene cluster for the polyene macrolactam sceliphrolactam in a Streptomyces strain isolated from mangrove sediment.

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