Ricardo Ribeiro Gama1, Yuyao Song2, Qihuang Zhang2, M Catherine Brown3, Jennifer Wang4, Steven Habbous3, Li Tong3, Shao Hui Huang5, Brian O'Sullivan5, John Waldron5, Wei Xu2, David Goldstein4, Geoffrey Liu3. 1. Head and Neck Surgery Department, Barretos Cancer Hospital, Barretos, Brazil. 2. Biostatistics Department, Princess Margaret Cancer Centre and Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. 3. Department of Medicine, Princess Margaret Cancer Centre and Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. 4. Department of Otolaryngology and Head and Neck Surgery, University Health Network and University of Toronto, Toronto, Canada. 5. Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada.
Abstract
BACKGROUND: Body mass index (BMI) has been associated variably with head and neck cancer outcomes. We evaluated the association between BMI at either diagnosis or at early adulthood head and neck cancer outcomes. METHODS: Patients with invasive head and neck squamous cell cancer at Princess Margaret Cancer Centre in Toronto, Canada, were surveyed on tobacco and alcohol exposure, performance status, comorbidities, and BMI at diagnosis. A subset also had data collected for BMI at early adulthood. RESULTS: With a median follow-up of 2.5 years, in 1279 analyzed patients, being overweight (hazard ratio [HR], 0.55; 95% confidence interval [CI], 0.4-0.8; p = .001) at diagnosis was associated with improved survival when compared with individuals with normal weight. In contrast, underweight patients at diagnosis were associated with a worse outcome (HR, 1.89; 95% CI, 1.2-3.1; p < .01). CONCLUSION: Being underweight at diagnosis was an independent, adverse prognostic factor, whereas being overweight conferred better prognosis. BMI in early adulthood was not associated strongly with head and neck cancer outcomes.
BACKGROUND: Body mass index (BMI) has been associated variably with head and neck cancer outcomes. We evaluated the association between BMI at either diagnosis or at early adulthood head and neck cancer outcomes. METHODS:Patients with invasive head and neck squamous cell cancer at Princess Margaret Cancer Centre in Toronto, Canada, were surveyed on tobacco and alcohol exposure, performance status, comorbidities, and BMI at diagnosis. A subset also had data collected for BMI at early adulthood. RESULTS: With a median follow-up of 2.5 years, in 1279 analyzed patients, being overweight (hazard ratio [HR], 0.55; 95% confidence interval [CI], 0.4-0.8; p = .001) at diagnosis was associated with improved survival when compared with individuals with normal weight. In contrast, underweight patients at diagnosis were associated with a worse outcome (HR, 1.89; 95% CI, 1.2-3.1; p < .01). CONCLUSION: Being underweight at diagnosis was an independent, adverse prognostic factor, whereas being overweight conferred better prognosis. BMI in early adulthood was not associated strongly with head and neck cancer outcomes.
Authors: Samantha Lang; Sarah Schimansky; Rhona Beynon; Christopher Penfold; Amy Davies; Andrea Waylen; Steven Thomas; Miranda Pring; Michael Pawlita; Tim Waterboer; Andrew R Ness Journal: Head Neck Date: 2019-01-30 Impact factor: 3.147
Authors: Kayla R Getz; Emily Bellile; Katie R Zarins; Cailey Rullman; Steven B Chinn; Jeremy M G Taylor; Laura S Rozek; Gregory T Wolf; Alison M Mondul Journal: Int J Cancer Date: 2020-12-15 Impact factor: 7.316
Authors: Ryan J Langdon; Rhona A Beynon; Kate Ingarfield; Riccardo E Marioni; Daniel L McCartney; Richard M Martin; Andy R Ness; Michael Pawlita; Tim Waterboer; Caroline Relton; Steven J Thomas; Rebecca C Richmond Journal: Clin Epigenetics Date: 2020-04-22 Impact factor: 6.551
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