Wenkai Zhou1,2, Canbang Peng3, Zheqi Liu4,5, Wei Cao6,7. 1. Department of Oral and Maxillofacial and Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. 2. Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, 200011, People's Republic of China. 3. School and Hospital of Stomatology, Kunming Medical University, Kunming, China. 4. Department of Oral and Maxillofacial and Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. 734672500@sjtu.edu.cn. 5. Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, 200011, People's Republic of China. 734672500@sjtu.edu.cn. 6. Department of Oral and Maxillofacial and Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. caowei561521@hotmail.com. 7. Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, 200011, People's Republic of China. caowei561521@hotmail.com.
Abstract
BACKGROUND: The risk factors for the survival of elderly patients with oral squamous cell carcinoma (OSCC) are multifarious. Here, we developed a novel clinical signature to serve as an indicator of prognosis in these patients. MATERIALS AND METHODS: Clinicopathological data were collected for 554 patients aged ≥ 60 years who were treated for primary OSCC. Overall survival (OS), disease-specific survival, and disease-free survival were the primary outcomes. RESULTS: Multivariate cox regression analysis showed that high N stage, low hemoglobin level, low body mass index (BMI), and high neutrophil-to-lymphocyte ratio (NLR) showed a poor survival (P < 0.05). A nomogram was constructed with a c-index of 0.702. CONCLUSION: A novel clinical signature including hemoglobin level, BMI, and NLR, which are obtained through noninvasive examinations can be used as prognostic indicators in clinical practice for elderly patients with OSCC.
BACKGROUND: The risk factors for the survival of elderly patients with oral squamous cell carcinoma (OSCC) are multifarious. Here, we developed a novel clinical signature to serve as an indicator of prognosis in these patients. MATERIALS AND METHODS: Clinicopathological data were collected for 554 patients aged ≥ 60 years who were treated for primary OSCC. Overall survival (OS), disease-specific survival, and disease-free survival were the primary outcomes. RESULTS: Multivariate cox regression analysis showed that high N stage, low hemoglobin level, low body mass index (BMI), and high neutrophil-to-lymphocyte ratio (NLR) showed a poor survival (P < 0.05). A nomogram was constructed with a c-index of 0.702. CONCLUSION: A novel clinical signature including hemoglobin level, BMI, and NLR, which are obtained through noninvasive examinations can be used as prognostic indicators in clinical practice for elderly patients with OSCC.
Authors: Katrin M Sjoquist; Lindsay A Renfro; R John Simes; Niall C Tebbutt; Stephen Clarke; Matthew T Seymour; Richard Adams; Timothy S Maughan; Leonard Saltz; Richard M Goldberg; Hans-Joachim Schmoll; Eric Van Cutsem; Jean-Yves Douillard; Paulo M Hoff; Joel Randolph Hecht; Christophe Tournigand; Cornelis J A Punt; Miriam Koopman; Herbert Hurwitz; Volker Heinemann; Alfredo Falcone; Rainer Porschen; Charles Fuchs; Eduardo Diaz-Rubio; Enrique Aranda; Carsten Bokemeyer; Ioannis Souglakos; Fairooz F Kabbinavar; Benoist Chibaudel; Jeffrey P Meyers; Daniel J Sargent; Aimery de Gramont; John R Zalcberg Journal: J Natl Cancer Inst Date: 2018-06-01 Impact factor: 13.506
Authors: Graeme J K Guthrie; Kellie A Charles; Campbell S D Roxburgh; Paul G Horgan; Donald C McMillan; Stephen J Clarke Journal: Crit Rev Oncol Hematol Date: 2013-04-17 Impact factor: 6.312
Authors: Joanna Szkandera; Armin Gerger; Bernadette Liegl-Atzwanger; Michael Stotz; Hellmut Samonigg; Ferdinand Ploner; Tatjana Stojakovic; Andreas Leithner; Martin Pichler Journal: PLoS One Date: 2014-09-10 Impact factor: 3.240
Authors: Daniel R Dickstein; Eric J Lehrer; Kristin Hsieh; Alexandra Hotca; Brianna M Jones; Ann Powers; Sonam Sharma; Jerry Liu; Vishal Gupta; Loren Mell; Zain Husain; Diana Kirke; Krzysztof Misiukiewicz; Marshall Posner; Eric Genden; Richard L Bakst Journal: Cancers (Basel) Date: 2022-06-05 Impact factor: 6.575