Xin Tan1, Danju Huang2, Fan Zhang3,4, Yingzhu Zhao5,6, Mingjian Tan1, Hongwan Li1, Hengyu Zhang1, Ke Wang1, Huimeng Li1, Dequan Liu1, Rong Guo1, Shicong Tang1,4. 1. Department of Breast Surgery, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming, China. 2. Department of Radiotherapy, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming, China. 3. Department of Thyroid Breast and Vascular Surgery, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China. 4. Department of Breast Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China. 5. Department of Hepatobiliary and Pancreatic Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. 6. Breast and Thyroid surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Abstract
BACKGROUND: Overweight and obesity have become a major health issue in the past 30 years. Several studies have already shown that obesity is significantly associated with a higher risk of developing breast cancer. However, few studies have assessed the prognostic value of the body mass index (BMI) in Asian populations. The purpose of this study was to retrospectively analyze the impact of BMI on the prognosis of breast cancer in overweight, under 160 cm tall patients from southern China. METHODS: We retrospectively analyzed data from 525 breast cancer patients diagnosed between 2003 to 2010 in a multi-center of China. After applying the exclusion criteria, 315 patients with complete data were retained. Their clinical and pathological characteristics were compared using the chi-square test. Survival analysis was performed with the Kaplan-Meier method. Univariate and multivariate analyses were performed using Cox regression to calculate hormone receptor status, HER-2 status, lymph node status, age, BMI and tumor size hazard ratio (HR), and 95% confidence intervals (95% CI). RESULTS: There was a strong correlation between BMI and age in the baseline feature analysis (P=0.001). After grouping the patients according to the molecular type of cancer, we found that in Luminal A and B, the BMI was related to age (P=0.002, P=0.010). The disease-free survival (DFS) and overall survival (OS) of patients with different BMI were not significantly different. This conclusion was also reached by pairwise comparison of subgroups. There was no significant difference in recurrence in patients from different BMI groups. We did not find a critical weight threshold associated with higher risk of recurrence. There were no statistically significant differences in treatment among the three BMI groups of overweight patients. CONCLUSIONS: We found that the BMI of Chinese breast cancer patients is related to age but not prognosis. 2021 Gland Surgery. All rights reserved.
BACKGROUND: Overweight and obesity have become a major health issue in the past 30 years. Several studies have already shown that obesity is significantly associated with a higher risk of developing breast cancer. However, few studies have assessed the prognostic value of the body mass index (BMI) in Asian populations. The purpose of this study was to retrospectively analyze the impact of BMI on the prognosis of breast cancer in overweight, under 160 cm tall patients from southern China. METHODS: We retrospectively analyzed data from 525 breast cancer patients diagnosed between 2003 to 2010 in a multi-center of China. After applying the exclusion criteria, 315 patients with complete data were retained. Their clinical and pathological characteristics were compared using the chi-square test. Survival analysis was performed with the Kaplan-Meier method. Univariate and multivariate analyses were performed using Cox regression to calculate hormone receptor status, HER-2 status, lymph node status, age, BMI and tumor size hazard ratio (HR), and 95% confidence intervals (95% CI). RESULTS: There was a strong correlation between BMI and age in the baseline feature analysis (P=0.001). After grouping the patients according to the molecular type of cancer, we found that in Luminal A and B, the BMI was related to age (P=0.002, P=0.010). The disease-free survival (DFS) and overall survival (OS) of patients with different BMI were not significantly different. This conclusion was also reached by pairwise comparison of subgroups. There was no significant difference in recurrence in patients from different BMI groups. We did not find a critical weight threshold associated with higher risk of recurrence. There were no statistically significant differences in treatment among the three BMI groups of overweight patients. CONCLUSIONS: We found that the BMI of Chinese breast cancer patients is related to age but not prognosis. 2021 Gland Surgery. All rights reserved.
Entities:
Keywords:
Breast cancer; body mass index (BMI); disease-free survival (DFS); obesity; overall survival (OS)
Authors: Jennifer A Ligibel; Catherine M Alfano; Kerry S Courneya; Wendy Demark-Wahnefried; Robert A Burger; Rowan T Chlebowski; Carol J Fabian; Ayca Gucalp; Dawn L Hershman; Melissa M Hudson; Lee W Jones; Madhuri Kakarala; Kirsten K Ness; Janette K Merrill; Dana S Wollins; Clifford A Hudis Journal: J Clin Oncol Date: 2014-10-01 Impact factor: 44.544
Authors: NaNa Keum; Darren C Greenwood; Dong Hoon Lee; Rockli Kim; Dagfinn Aune; Woong Ju; Frank B Hu; Edward L Giovannucci Journal: J Natl Cancer Inst Date: 2015-01-24 Impact factor: 13.506
Authors: Sabrina Schlesinger; Sabine Siegert; Manja Koch; Jessica Walter; Nils Heits; Sebastian Hinz; Gunnar Jacobs; Jochen Hampe; Clemens Schafmayer; Ute Nöthlings Journal: Cancer Causes Control Date: 2014-07-19 Impact factor: 2.506
Authors: Andrea Emese Jakab; Erzsébet Valéria Hidvégi; Miklós Illyés; Attila Cziráki; Tibor Kalmár; Zoltán Maróti; Csaba Bereczki Journal: Orv Hetil Date: 2020-01 Impact factor: 0.540