Literature DB >> 2832238

Localization of radiolabeled monoclonal antibody S74 in human scirrhous type gastric cancer xenografts in nude mice.

T Yokota1, T Takahashi, T Yamaguchi, E Otsuji, K Sawai, S Kitai, K Kitamura, A Noguchi, T Ahn.   

Abstract

A mouse monoclonal antibody (MoAb), S74 against a human scirrhous gastric carcinoma cell line was developed. The radioiodinated antibody bound preferentially in vivo to xenografted tumors rather than to normal tissue, whereas tumor uptake of normal mouse IgG did not occur. Thus this MoAb was able to selectively localize a human tumor in an animal model, and clinically it may enable immunotherapy against scirrhous carcinoma of the stomach.

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Year:  1987        PMID： 2832238     DOI： 10.1007/BF02776741

Source DB:  PubMed          Journal:  Gastroenterol Jpn        ISSN： 0435-1339


  18 in total

1.  [In vivo localization of monoclonal antibody A-7 to human colon cancer inoculated into nude mice].

Authors:  M Takahashi
Journal:  Nihon Shokakibyo Gakkai Zasshi       Date:  1985-06

2.  Phase II clinical trial of a murine monoclonal antibody cytotoxic for gastrointestinal adenocarcinoma.

Authors:  H F Sears; D Herlyn; Z Steplewski; H Koprowski
Journal:  Cancer Res       Date:  1985-11       Impact factor: 12.701

3.  Inhibition of growth of colorectal carcinoma in nude mice by monoclonal antibody.

Authors:  D M Herlyn; Z Steplewski; M F Herlyn; H Koprowski
Journal:  Cancer Res       Date:  1980-03       Impact factor: 12.701

4.  A monoclonal antibody against human colon cancers.

Authors:  H Kotanagi; T Takahashi; T Masuko; Y Hashimoto; K Koyama
Journal:  Tohoku J Exp Med       Date:  1986-04       Impact factor: 1.848

5.  Tumor localization in patients by radiolabeled monoclonal antibodies against colon carcinoma.

Authors:  J P Mach; J F Chatal; J D Lumbroso; F Buchegger; M Forni; J Ritschard; C Berche; J Y Douillard; S Carrel; M Herlyn
Journal:  Cancer Res       Date:  1983-11       Impact factor: 12.701

6.  Metastatic colon carcinoma detected with radiolabeled F(ab')2 monoclonal antibody fragments.

Authors:  P J Moldofsky; J Powe; C B Mulhern; N Hammond; H F Sears; R A Gatenby; Z Steplewski; H Koprowski
Journal:  Radiology       Date:  1983-11       Impact factor: 11.105

7.  Monoclonal anticolon carcinoma antibodies in complement-dependent cytotoxicity.

Authors:  D M Herlyn; H Koprowski
Journal:  Int J Cancer       Date:  1981-06-15       Impact factor: 7.396

8.  Location of metastatic breast carcinoma by a monoclonal antibody chelate labelled with indium-111.

Authors:  R M Rainsbury; R J Ott; J H Westwood; T S Kalirai; R C Coombes; V R McCready; A M Neville; J C Gazet
Journal:  Lancet       Date:  1983-10-22       Impact factor: 79.321

9.  Localization of human breast-carcinoma xenografts using antibodies to carcinoembryonic antigen.

Authors:  V Moshakis; M J Bailey; M G Ormerod; J H Westwood; A M Neville
Journal:  Br J Cancer       Date:  1981-05       Impact factor: 7.640

10.  Localization of human tumour xenografts after i.v. administration of radiolabeled monoclonal antibodies.

Authors:  V Moshakis; R A McIlhinney; D Raghavan; A M Neville
Journal:  Br J Cancer       Date:  1981-07       Impact factor: 7.640
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  2 in total

1.  Characterization of a newly established cell line (JR-St) derived from human gastric signet ring cell cancer, producing tumor markers.

Authors:  A Terano; R Nakada; H Mutoh; H Hiraishi; S Ota; S Shiina; T Shimada; Y Itoh; K Kimura; J Shiga
Journal:  Gastroenterol Jpn       Date:  1991-02

2.  Immunohistochemical detection of biotin-labeled murine monoclonal antibody in nude mice transplanted with human colon cancer.

Authors:  T Yokota; T Takahashi; T Yamaguchi; K Kitamura; K Sawai
Journal:  Gastroenterol Jpn       Date:  1989-02
  2 in total

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