Literature DB >> 7248144

Localization of human breast-carcinoma xenografts using antibodies to carcinoembryonic antigen.

V Moshakis, M J Bailey, M G Ormerod, J H Westwood, A M Neville.   

Abstract

Affinity-purified antibodies to carcinoembryonic antigen (CEA) have been injected into immune-suppressed mice bearing xenografts of human breast tumours. It has been shown that the antibodies localized in the tumours but not in normal tissues. The degree of tumour localization correlates with the amount of tumour CEA, and is unaffected by levels of circulating CEA or CEA/anti-CEA immune complexes.

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Year:  1981        PMID： 7248144      PMCID： PMC2010670          DOI： 10.1038/bjc.1981.86

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  21 in total

1.  A new antigen on the epithelial membrane: its immunoperoxidase localisation in normal and neoplastic tissue.

Authors:  E Heyderman; K Steele; M G Ormerod
Journal:  J Clin Pathol       Date:  1979-01       Impact factor: 3.411

2.  A shorter immunoperoxidase technique for the demonstration of carcinoembryonic antigen and other cell products.

Authors:  E Heyderman; A M Neville
Journal:  J Clin Pathol       Date:  1977-02       Impact factor: 3.411

3.  In vivo localisation of radiolabelled antibodies to carcinoembryonic antigen in human colon carcinoma grafted into nude mice.

Authors:  J P Mach; S Carrel; C Merenda; B Sordat; J C Cerottini
Journal:  Nature       Date:  1974-04-19       Impact factor: 49.962

4.  Localization of human GW-39 tumors in hamsters by radiolabeled heterospecific antibody to carcinoembryonic antigen.

Authors:  F J Primus; R H Wang; D M Goldenberg; H J Hansen
Journal:  Cancer Res       Date:  1973-11       Impact factor: 12.701

5.  Clinical correlation between CEA and breast cancer.

Authors:  D C Tormey; T P Waalkes
Journal:  Cancer       Date:  1978-09       Impact factor: 6.860

6.  Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning.

Authors:  D M Goldenberg; F DeLand; E Kim; S Bennett; F J Primus; J R van Nagell; N Estes; P DeSimone; P Rayburn
Journal:  N Engl J Med       Date:  1978-06-22       Impact factor: 91.245

7.  Role of plasma carcinoembryonic antigen in diagnosis of gastrointestinal, mammary, and bronchial carcinoma.

Authors:  D J Laurence; U Stevens; R Bettelheim; D Darcy; C Leese; C Turberville; P Alexander; E W Johns; A M Neville
Journal:  Br Med J       Date:  1972-09-09

8.  Non-specific cytotoxicity of spleen cells in mice bearing transplanted chemically induced fibrosarcomas.

Authors:  A Mantovani; R Evans; P Alexander
Journal:  Br J Cancer       Date:  1977-07       Impact factor: 7.640

9.  Improved immune-suppression techniques for the exongrafting of human tumours.

Authors:  G G Steel; V D Courtenay; A Y Rostom
Journal:  Br J Cancer       Date:  1978-02       Impact factor: 7.640

10.  Studies on the structure and immunological activity of carcinoembryonic antigen - the role of disulphide bonds.

Authors:  J H Westwood; P Thomas
Journal:  Br J Cancer       Date:  1975-12       Impact factor: 7.640
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  12 in total

1.  Radioimmunodetection of cancer: problems and potential.

Authors:  E M Rankin; J G McVie
Journal:  Br Med J (Clin Res Ed)       Date:  1983-11-12

2.  Comparative clinical pharmacology of [111In]-labeled murine monoclonal antibodies.

Authors:  M G Rosenblum; J L Murray; L Lamki; G David; D Carlo
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333

Review 3.  Antibody-mediated targeting in the treatment and diagnosis of cancer: an overview.

Authors:  C H Ford; A G Casson
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

4.  Radioiodinated peanut lectin: a potential radiopharmaceutical for immunodetection of carcinoma expressing the T antigen.

Authors:  P L Zabel; A A Noujaim; A Shysh; J Bray
Journal:  Eur J Nucl Med       Date:  1983

5.  The detection of virally induced tumors by 131I- and 125I-labeled syngeneic monoclonal antibodies.

Authors:  D Berends; J L van Gaalen; E H Rhijnsburger; N J de Both; W Breeman; W H Bakker; P Kooy
Journal:  Cancer Immunol Immunother       Date:  1988       Impact factor: 6.968

6.  Localization of radiolabeled monoclonal antibody S74 in human scirrhous type gastric cancer xenografts in nude mice.

Authors:  T Yokota; T Takahashi; T Yamaguchi; E Otsuji; K Sawai; S Kitai; K Kitamura; A Noguchi; T Ahn
Journal:  Gastroenterol Jpn       Date:  1987-12

Review 7.  Antitumor monoclonal antibodies for radioimmunodetection of tumors and drug targeting.

Authors:  R W Baldwin; M V Pimm
Journal:  Cancer Metastasis Rev       Date:  1983       Impact factor: 9.264

8.  Radiolabeled fragments of monoclonal antibodies against carcinoembryonic antigen for localization of human colon carcinoma grafted into nude mice.

Authors:  F Buchegger; C M Haskell; M Schreyer; B R Scazziga; S Randin; S Carrel; J P Mach
Journal:  J Exp Med       Date:  1983-08-01       Impact factor: 14.307

9.  Cellular distribution of monoclonal antibody in human tumours after i.v. administration.

Authors:  V Moshakis; R A McIlhinney; A M Neville
Journal:  Br J Cancer       Date:  1981-11       Impact factor: 7.640

Review 10.  The response to chemotherapy of a variety of human tumour xenografts.

Authors:  G G Steel; V D Courtenay; M J Peckham
Journal:  Br J Cancer       Date:  1983-01       Impact factor: 7.640
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