Literature DB >> 3526636

A monoclonal antibody against human colon cancers.

H Kotanagi, T Takahashi, T Masuko, Y Hashimoto, K Koyama.   

Abstract

A monoclonal antibody was prepared by hybridizing mouse myeloma cells with spleen cells from the mouse which was immunized with human colon cancer transplanted in nude mice. The reactivity of the monoclonal antibody, named A7, was tested by immunoperoxidase method. A7 reacted strongly with human adenocarcinoma cell lines and carcinoembryonic antigen (CEA). In surgical specimens, A7 reacted with 10 cancer tissues and 2 normal colon mucosa from 19 colorectal cancer patients. A7 did not react with other cancers. It was thought that A7 reacted with colon- or colon cancer-specific CEA. The reactivity of A7 with colorectal cancers was markedly reduced by preoperative irradiation.

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Year:  1986        PMID： 3526636     DOI： 10.1620/tjem.148.353

Source DB:  PubMed          Journal:  Tohoku J Exp Med        ISSN： 0040-8727            Impact factor:   1.848


  21 in total

1.  Fate of antibody-neocarzinostatin conjugates bound to human colonic carcinoma cells in vitro.

Authors:  T Yokota; T Yamaguchi; K Kitamura; T Takahashi
Journal:  In Vitro Cell Dev Biol       Date:  1992 Sep-Oct

2.  Specific cytotoxic effect of neocarzinostatin conjugated to monoclonal antibody A7 on human pancreatic carcinoma.

Authors:  E Otsuji; T Takahashi; T Yamaguchi; N Yamaguchi; J Imanishi
Journal:  Gastroenterol Jpn       Date:  1990-04

3.  The role of monoclonal antibody A7 as a drug modifier in cancer therapy.

Authors:  K Kitamura; T Miyagaki; N Yamaoka; H Tsurumi; A Noguchi; T Yamaguchi; T Takahashi
Journal:  Cancer Immunol Immunother       Date:  1993       Impact factor: 6.968

4.  Expression of the cell surface antigen detected by the monoclonal antibody A7 in pancreatic carcinoma cell lines.

Authors:  E Otsuji; T Yamaguchi; N Yamaguchi; K Koyama; J Imanishi; N Yamaoka; T Takahashi
Journal:  Surg Today       Date:  1992       Impact factor: 2.549

5.  Improved survival of mice bearing liver metastases of colon cancer cells treated with a combination of radioimmunotherapy and antiangiogenic therapy.

Authors:  Seigo Kinuya; Kunihiko Yokoyama; Kiyoshi Koshida; Hirofumi Mori; Kazuhiro Shiba; Naoto Watanabe; Noriyuki Shuke; Jingming Bai; Takatoshi Michigishi; Norihisa Tonami
Journal:  Eur J Nucl Med Mol Imaging       Date:  2004-02-28       Impact factor: 9.236

6.  Feasibility of 186Re-radioimmunotherapy for treatment in an adjuvant setting of colon cancer.

Authors:  Seigo Kinuya; Kunihiko Yokoyama; Mishiroku Izumo; Takami Sorita; Takashi Obata; Hirofumi Mori; Kazuhiro Shiba; Naoto Watanabe; Noriyuki Shuke; Takatoshi Michigishi; Norihisa Tonami
Journal:  J Cancer Res Clin Oncol       Date:  2003-07-09       Impact factor: 4.553

7.  Localization of radiolabeled monoclonal antibody S74 in human scirrhous type gastric cancer xenografts in nude mice.

Authors:  T Yokota; T Takahashi; T Yamaguchi; E Otsuji; K Sawai; S Kitai; K Kitamura; A Noguchi; T Ahn
Journal:  Gastroenterol Jpn       Date:  1987-12

8.  Immunohistochemical detection of biotin-labeled murine monoclonal antibody in nude mice transplanted with human colon cancer.

Authors:  T Yokota; T Takahashi; T Yamaguchi; K Kitamura; K Sawai
Journal:  Gastroenterol Jpn       Date:  1989-02

9.  Monoclonal antibody A7-superparamagnetic iron oxide as contrast agent of MR imaging of rectal carcinoma.

Authors:  A Toma; E Otsuji; Y Kuriu; K Okamoto; D Ichikawa; A Hagiwara; H Ito; T Nishimura; H Yamagishi
Journal:  Br J Cancer       Date:  2005-07-11       Impact factor: 7.640

10.  In vitro reactivity and in vivo biodistribution of the monoclonal antibody A7 using human gastric carcinoma cell lines.

Authors:  N Yamaoka; T Yamaguchi; E Otsuji; M Kato; T Kotani; K Kitamura; T Takahashi
Journal:  Br J Cancer       Date:  1994-09       Impact factor: 7.640
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