Literature DB >> 2651205

Immunohistochemical detection of biotin-labeled murine monoclonal antibody in nude mice transplanted with human colon cancer.

T Yokota1, T Takahashi, T Yamaguchi, K Kitamura, K Sawai.   

Abstract

The tissue localization of biotin-labeled murine monoclonal antibody (MAb) A7 directed against human colonic cancer was examined in tumor-bearing nude mice following intravenous administration. MAb A7 did not react with any murine visceral organs. At 24 hr after biotin-labeled A7 injection, the tumor was stained by the avidin-biotin peroxidase complex method, but no staining was observed after injection of biotin-labeled normal mouse Ig G in the control group. Biotin-labeled MAb was found to be suitable for the detection of the xenografted tumor of nude mice. Our purpose was to provide a new method concerning the distribution of biotin-labeled MAb in vivo.

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Year:  1989        PMID： 2651205     DOI： 10.1007/bf02774866

Source DB:  PubMed          Journal:  Gastroenterol Jpn        ISSN： 0435-1339


  9 in total

1.  Clinical application of monoclonal antibody-drug conjugates for immunotargeting chemotherapy of colorectal carcinoma.

Authors:  T Takahashi; T Yamaguchi; K Kitamura; H Suzuyama; M Honda; T Yokota; H Kotanagi; M Takahashi; Y Hashimoto
Journal:  Cancer       Date:  1988-03-01       Impact factor: 6.860

2.  Experimental immunotherapy of human breast carcinomas implanted in nude mice with a mixture of monoclonal antibodies against human milk fat globule components.

Authors:  R L Ceriani; E W Blank; J A Peterson
Journal:  Cancer Res       Date:  1987-01-15       Impact factor: 12.701

3.  A monoclonal antibody against human colon cancers.

Authors:  H Kotanagi; T Takahashi; T Masuko; Y Hashimoto; K Koyama
Journal:  Tohoku J Exp Med       Date:  1986-04       Impact factor: 1.848

4.  Radioimmunodetection of human glioma xenografts by monoclonal antibody to epidermal growth factor receptor.

Authors:  H Takahashi; D Herlyn; B Atkinson; J Powe; U Rodeck; A Alavi; D A Bruce; H Koprowski
Journal:  Cancer Res       Date:  1987-07-15       Impact factor: 12.701

5.  Pharmacokinetics of 99mTc(Sn)- and 131I-labeled anti-carcinoembryonic antigen monoclonal antibody fragments in nude mice.

Authors:  A M Zimmer; J M Kazikiewicz; S T Rosen; S M Spies
Journal:  Cancer Res       Date:  1987-03-15       Impact factor: 12.701

6.  Pharmacokinetics of the monoclonal antibody B72.3 and its fragments labeled with either 125I or 111In.

Authors:  B A Brown; R D Comeau; P L Jones; F A Liberatore; W P Neacy; H Sands; B M Gallagher
Journal:  Cancer Res       Date:  1987-02-15       Impact factor: 12.701

7.  Potent effects of the monoclonal antibody-mitomycin C conjugate on human colon cancers.

Authors:  H Kotanagi; K Fukuda; N Ogata; M Takahashi; T Masuda; K Koyama; T Takahashi
Journal:  Jpn J Surg       Date:  1987-01

8.  Targeting of murine radiolabeled monoclonal antibodies in the lymphatics.

Authors:  R J Parker; A M Keenan; S K Dower; M A Steller; O D Holton; S M Sieber; J N Weinstein
Journal:  Cancer Res       Date:  1987-04-15       Impact factor: 12.701

9.  Localization of radiolabeled monoclonal antibody S74 in human scirrhous type gastric cancer xenografts in nude mice.

Authors:  T Yokota; T Takahashi; T Yamaguchi; E Otsuji; K Sawai; S Kitai; K Kitamura; A Noguchi; T Ahn
Journal:  Gastroenterol Jpn       Date:  1987-12
  9 in total

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