Mahmoud El-Gohary1, Daniel Peterson2, Geetanjali Gera3, Fay B Horak4, Jessie M Huisinga5. 1. APDM, Inc., Portland, OR. 2. Department of Exercise Science & Health Promotion, Arizona State University, Tempe, AZ. 3. Department of Neurology, Oregon Health & Science University, Portland, OR. 4. APDM, Inc., Portland, OR; Department of Neurology, Oregon Health & Science University, Portland, OR. 5. Landon Center on Aging, University of Kansas Medical Center, Kansas City, KS. Electronic address: jhuisinga@kumc.edu.
Abstract
OBJECTIVE: To test the validity of wearable inertial sensors to provide objective measures of postural stepping responses to the push and release clinical test in people with multiple sclerosis. DESIGN: Cross-sectional study. SETTING: University medical center balance disorder laboratory. PARTICIPANTS: Total sample N=73; persons with multiple sclerosis (PwMS) n=52; healthy controls n=21. MAIN OUTCOME MEASURES: Stepping latency, time and number of steps required to reach stability, and initial step length were calculated using 3 inertial measurement units placed on participants' lumbar spine and feet. RESULTS: Correlations between inertial sensor measures and measures obtained from the laboratory-based systems were moderate to strong and statistically significant for all variables: time to release (r=.992), latency (r=.655), time to stability (r=.847), time of first heel strike (r=.665), number of steps (r=.825), and first step length (r=.592). Compared with healthy controls, PwMS demonstrated a longer time to stability and required a larger number of steps to reach stability. CONCLUSIONS: The instrumented push and release test is a valid measure of postural responses in PwMS and could be used as a clinical outcome measures for patient care decisions or for clinical trials aimed at improving postural control in PwMS.
OBJECTIVE: To test the validity of wearable inertial sensors to provide objective measures of postural stepping responses to the push and release clinical test in people with multiple sclerosis. DESIGN: Cross-sectional study. SETTING: University medical center balance disorder laboratory. PARTICIPANTS: Total sample N=73; persons with multiple sclerosis (PwMS) n=52; healthy controls n=21. MAIN OUTCOME MEASURES: Stepping latency, time and number of steps required to reach stability, and initial step length were calculated using 3 inertial measurement units placed on participants' lumbar spine and feet. RESULTS: Correlations between inertial sensor measures and measures obtained from the laboratory-based systems were moderate to strong and statistically significant for all variables: time to release (r=.992), latency (r=.655), time to stability (r=.847), time of first heel strike (r=.665), number of steps (r=.825), and first step length (r=.592). Compared with healthy controls, PwMS demonstrated a longer time to stability and required a larger number of steps to reach stability. CONCLUSIONS: The instrumented push and release test is a valid measure of postural responses in PwMS and could be used as a clinical outcome measures for patient care decisions or for clinical trials aimed at improving postural control in PwMS.
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