E Flower1, V Do2, J Sykes3, C Dempsey4, L Holloway5, K Summerhayes6, D I Thwaites7. 1. Crown Princess Mary Cancer Centre, Westmead, NSW, Australia; Institute of Medical Physics, School of Physics, University of Sydney, Camperdown, NSW, Australia. Electronic address: emily.flower@health.nsw.gov.au. 2. Crown Princess Mary Cancer Centre, Westmead, NSW, Australia; Sydney Medical School Nepean, University of Sydney, Kingswood, NSW, Australia. 3. Blacktown Cancer & Haematology Centre, Blacktown, NSW, Australia. 4. Department of Radiation Oncology, University of Washington, WA; Department of Radiation Oncology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia; School of Health Sciences, University of Newcastle, Newcastle, NSW, Australia. 5. Institute of Medical Physics, School of Physics, University of Sydney, Camperdown, NSW, Australia; Ingham Institute and Liverpool and Macarthur Cancer Therapy Centres, Liverpool, NSW, Australia; Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia; South Western Sydney Clinical School, University of New South Wales, Liverpool, NSW, Australia. 6. Crown Princess Mary Cancer Centre, Westmead, NSW, Australia. 7. Institute of Medical Physics, School of Physics, University of Sydney, Camperdown, NSW, Australia.
Abstract
PURPOSE: The purpose of this study was to determine the effect of deformable image registration (DIR) on cumulative organ at risk dose-volume histogram (DVH) parameter summation for more than three brachytherapy fractions. The reproducibility of different methods of DIR was tested. DIR was then used to assess the stability of the anatomic position of the DVH parameters within the bladder and rectum. METHODS AND MATERIALS: DIR was completed for 39 consecutive cervical cancer brachytherapy patients' planning CTs. Accumulated DVH parameters (D2cc and D0.1cc) for bladder and rectum were compared with dose summation without DIR. Reproducibility of DIR results was assessed for different methods of implementation based on adding contour biases added to the DIR algorithm. VolD2cc and VolD0.1cc structures were created from the overlap of the D2cc and D0.1cc isodose and the bladder or rectum, respectively. The overlap of VolD2cc and VolD0.1cc structures was calculated using the Dice similarity coefficient. RESULTS: DIR accumulated D2cc and D0.1cc decreased by an average of 2.9% and 4.2% for bladder and 5.08% and 2.8% for rectum compared with no DIR. DIR was most reproducible when the bladder or rectum contour was masked. The average Dice similarity coefficient was 0.78 and 0.61 for the bladder D2cc and D0.1cc as well as 0.83 and 0.62 for rectal D2cc and D0.1cc, respectively. CONCLUSIONS: Dose decreases were observed for accumulated DVH parameters using DIR. Adding contour-based biases to the algorithm increases the reproducibility of D2cc and D0.1cc accumulation. The anatomic position of VolD2cc was more stable than VolD0.1cc. Crown
PURPOSE: The purpose of this study was to determine the effect of deformable image registration (DIR) on cumulative organ at risk dose-volume histogram (DVH) parameter summation for more than three brachytherapy fractions. The reproducibility of different methods of DIR was tested. DIR was then used to assess the stability of the anatomic position of the DVH parameters within the bladder and rectum. METHODS AND MATERIALS: DIR was completed for 39 consecutive cervical cancer brachytherapy patients' planning CTs. Accumulated DVH parameters (D2cc and D0.1cc) for bladder and rectum were compared with dose summation without DIR. Reproducibility of DIR results was assessed for different methods of implementation based on adding contour biases added to the DIR algorithm. VolD2cc and VolD0.1cc structures were created from the overlap of the D2cc and D0.1cc isodose and the bladder or rectum, respectively. The overlap of VolD2cc and VolD0.1cc structures was calculated using the Dice similarity coefficient. RESULTS: DIR accumulated D2cc and D0.1cc decreased by an average of 2.9% and 4.2% for bladder and 5.08% and 2.8% for rectum compared with no DIR. DIR was most reproducible when the bladder or rectum contour was masked. The average Dice similarity coefficient was 0.78 and 0.61 for the bladder D2cc and D0.1cc as well as 0.83 and 0.62 for rectal D2cc and D0.1cc, respectively. CONCLUSIONS: Dose decreases were observed for accumulated DVH parameters using DIR. Adding contour-based biases to the algorithm increases the reproducibility of D2cc and D0.1cc accumulation. The anatomic position of VolD2cc was more stable than VolD0.1cc. Crown
Authors: Hayeon Kim; Yongsook C Lee; Stanley H Benedict; Brandon Dyer; Michael Price; Yi Rong; Ananth Ravi; Eric Leung; Sushil Beriwal; Mark E Bernard; Jyoti Mayadev; Jessica R L Leif; Ying Xiao Journal: Int J Radiat Oncol Biol Phys Date: 2021-06-17 Impact factor: 7.038
Authors: Arun George Paul; Adrian Nalichowski; Judith Abrams; Peter Paximadis; Ling Zhuang; Steven Miller Journal: J Contemp Brachytherapy Date: 2018-06-28
Authors: Jeffrey Barber; Johnson Yuen; Michael Jameson; Laurel Schmidt; Jonathan Sykes; Alison Gray; Nicholas Hardcastle; Callie Choong; Joel Poder; Amy Walker; Adam Yeo; Ben Archibald-Heeren; Kristie Harrison; Annette Haworth; David Thwaites Journal: J Med Radiat Sci Date: 2020-08-02