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Literature DB >> 28144654

The small molecule JIB-04 disrupts O₂ binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.

Barbara Cascella¹, Soon Goo Lee², Sukrit Singh³, Joseph M Jez², Liviu M Mirica³.

Abstract

JIB-04, a specific inhibitor of the O2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O2 in KDM4A/JMJD2A through a continuous O2-consumption assay, X-ray crystal structure data, and molecular docking.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2017 PMID： 28144654 PMCID： PMC5511625 DOI： 10.1039/c6cc09882g

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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