Literature DB >> 22241642

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.

Esther C Y Woon1, Anthony Tumber, Akane Kawamura, Lars Hillringhaus, Wei Ge, Nathan R Rose, Jerome H Y Ma, Mun Chiang Chan, Louise J Walport, Ka Hing Che, Stanley S Ng, Brian D Marsden, Udo Oppermann, Michael A McDonough, Christopher J Schofield.   

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Year:  2012        PMID： 22241642     DOI： 10.1002/anie.201107833

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  28 in total

Review 1.  Small molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases.

Authors:  Zhanxin Wang; Dinshaw J Patel
Journal:  Q Rev Biophys       Date:  2013-09-02       Impact factor: 5.318

2.  The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.

Authors:  Barbara Cascella; Soon Goo Lee; Sukrit Singh; Joseph M Jez; Liviu M Mirica
Journal:  Chem Commun (Camb)       Date:  2017-02-09       Impact factor: 6.222

Review 3.  Inhibitors of Protein Methyltransferases and Demethylases.

Authors:  H Ümit Kaniskan; Michael L Martini; Jian Jin
Journal:  Chem Rev       Date:  2017-03-24       Impact factor: 60.622

Review 4.  The role of histone demethylases in cancer therapy.

Authors:  Inga Hoffmann; Martin Roatsch; Martin L Schmitt; Luca Carlino; Martin Pippel; Wolfgang Sippl; Manfred Jung
Journal:  Mol Oncol       Date:  2012-08-07       Impact factor: 6.603

Review 5.  Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.

Authors:  David F Tough; Huw D Lewis; Inmaculada Rioja; Matthew J Lindon; Rab K Prinjha
Journal:  Br J Pharmacol       Date:  2014-11       Impact factor: 8.739

Review 6.  Marked for death: targeting epigenetic changes in cancer.

Authors:  Sophia Xiao Pfister; Alan Ashworth
Journal:  Nat Rev Drug Discov       Date:  2017-03-10       Impact factor: 84.694

7.  Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of γ-butyrobetaine hydroxylase.

Authors:  Anna M Rydzik; Rasheduzzaman Chowdhury; Grazyna T Kochan; Sophie T Williams; Michael A McDonough; Akane Kawamura; Christopher J Schofield
Journal:  Chem Sci       Date:  2014-05-01       Impact factor: 9.825

8.  Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy.

Authors:  Nitai Charan Giri; Lisa Passantino; Hong Sun; Maria Antonietta Zoroddu; Max Costa; Michael J Maroney
Journal:  Biochemistry       Date:  2013-06-07       Impact factor: 3.162

9.  Quantitative analysis of histone demethylase probes using fluorescence polarization.

Authors:  Wenqing Xu; Jessica D Podoll; Xuan Dong; Anthony Tumber; Udo Oppermann; Xiang Wang
Journal:  J Med Chem       Date:  2013-06-13       Impact factor: 7.446

10.  Structural analysis of human KDM5B guides histone demethylase inhibitor development.

Authors:  Catrine Johansson; Srikannathasan Velupillai; Anthony Tumber; Aleksandra Szykowska; Edward S Hookway; Radoslaw P Nowak; Claire Strain-Damerell; Carina Gileadi; Martin Philpott; Nicola Burgess-Brown; Na Wu; Jola Kopec; Andrea Nuzzi; Holger Steuber; Ursula Egner; Volker Badock; Shonagh Munro; Nicholas B LaThangue; Sue Westaway; Jack Brown; Nick Athanasou; Rab Prinjha; Paul E Brennan; Udo Oppermann
Journal:  Nat Chem Biol       Date:  2016-05-23       Impact factor: 15.040
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