Literature DB >> 35838529

Recent Advances with KDM4 Inhibitors and Potential Applications.

Qiong Wu1, Brandon Young2, Yan Wang3, Andrew M Davidoff1, Zoran Rankovic2, Jun Yang1,4.   

Abstract

The histone lysine demethylase 4 (KDM4) family plays an important role in regulating gene transcription, DNA repair, and metabolism. The dysregulation of KDM4 functions is associated with many human disorders, including cancer, obesity, and cardiovascular diseases. Selective and potent KDM4 inhibitors may help not only to understand the role of KDM4 in these disorders but also to provide potential therapeutic opportunities. Here, we provide an overview of the field and discuss current status, challenges, and opportunities lying ahead in the development of KDM4-based anticancer therapeutics.

Entities:  

Mesh：

Substances：

Year:  2022        PMID： 35838529      PMCID： PMC9531573          DOI： 10.1021/acs.jmedchem.2c00680

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   8.039


  151 in total

1.  Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors.

Authors:  Brian Lohse; Anders L Nielsen; Jan B L Kristensen; Charlotte Helgstrand; Paul A C Cloos; Lars Olsen; Michael Gajhede; Rasmus P Clausen; Jesper L Kristensen
Journal:  Angew Chem Int Ed Engl       Date:  2011-08-25       Impact factor: 15.336

2.  Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitors.

Authors:  Zhen Fang; Tian-Qi Wang; Hui Li; Guo Zhang; Xiao-Ai Wu; Li Yang; Yu-Lan Peng; Jun Zou; Lin-Li Li; Rong Xiang; Sheng-Yong Yang
Journal:  Bioorg Med Chem Lett       Date:  2017-05-03       Impact factor: 2.823

3.  Geldanamycin, a new antibiotic.

Authors:  C DeBoer; P A Meulman; R J Wnuk; D H Peterson
Journal:  J Antibiot (Tokyo)       Date:  1970-09       Impact factor: 2.649

4.  Identification and characterization of small molecule inhibitors of a plant homeodomain finger.

Authors:  Elise K Wagner; Nidhi Nath; Rod Flemming; John B Feltenberger; John M Denu
Journal:  Biochemistry       Date:  2012-10-02       Impact factor: 3.162

5.  Tetrazolylhydrazides as Selective Fragment-Like Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.

Authors:  Nicole Rüger; Martin Roatsch; Thomas Emmrich; Henriette Franz; Roland Schüle; Manfred Jung; Andreas Link
Journal:  ChemMedChem       Date:  2015-09-04       Impact factor: 3.466

6.  KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors.

Authors:  Joshua C Black; Amity L Manning; Capucine Van Rechem; Jaegil Kim; Brendon Ladd; Juok Cho; Cristiana M Pineda; Nancy Murphy; Danette L Daniels; Cristina Montagna; Peter W Lewis; Kimberly Glass; C David Allis; Nicholas J Dyson; Gad Getz; Johnathan R Whetstine
Journal:  Cell       Date:  2013-07-18       Impact factor: 41.582

7.  KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism.

Authors:  Erhu Zhao; Jane Ding; Yingfeng Xia; Mengling Liu; Bingwei Ye; Jeong-Hyeon Choi; Chunhong Yan; Zheng Dong; Shuang Huang; Yunhong Zha; Liqun Yang; Hongjuan Cui; Han-Fei Ding
Journal:  Cell Rep       Date:  2016-01-07       Impact factor: 9.423

8.  Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

Authors:  Oliver N F King; Xuan Shirley Li; Masaaki Sakurai; Akane Kawamura; Nathan R Rose; Stanley S Ng; Amy M Quinn; Ganesha Rai; Bryan T Mott; Paul Beswick; Robert J Klose; Udo Oppermann; Ajit Jadhav; Tom D Heightman; David J Maloney; Christopher J Schofield; Anton Simeonov
Journal:  PLoS One       Date:  2010-11-23       Impact factor: 3.240

9.  Benzo[b]tellurophenes as a Potential Histone H3 Lysine 9 Demethylase (KDM4) Inhibitor.

Authors:  Yoon-Jung Kim; Dong Hoon Lee; Yong-Sung Choi; Jin-Hyun Jeong; So Hee Kwon
Journal:  Int J Mol Sci       Date:  2019-11-25       Impact factor: 5.923

10.  Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer.

Authors:  G Liu; A Bollig-Fischer; B Kreike; M J van de Vijver; J Abrams; S P Ethier; Z-Q Yang
Journal:  Oncogene       Date:  2009-09-28       Impact factor: 9.867
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.