| Literature DB >> 28086100 |
Joshua Carter1, Connor Hoffman1, Blake Wiedenheft2.
Abstract
RNA-guided Cas9 endonucleases protect bacteria from viral infection and have been creatively repurposed as programmable molecular scalpels for surgical manipulation of DNA. Now, two papers in Cell (Pawluk et al. and Rauch et al.) identify viral proteins that suppress Cas9 and may function like molecular sheaths for the Cas9 scalpel.Entities:
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Year: 2017 PMID: 28086100 PMCID: PMC5480287 DOI: 10.1016/j.cell.2016.12.007
Source DB: PubMed Journal: Cell ISSN: 0092-8674 Impact factor: 41.582