Task-Based Design of Fluence Field Modulation in CT for Model-Based Iterative Reconstruction.

A task-driven imaging framework for prospective fluence field modulation (FFM) is developed in this paper. The design approach uses a system model that includes a parameterized FFM acquisition and model-based iterative reconstruction (MBIR) for image formation. Using prior anatomical knowledge (e.g. from a low-dose 3D scout image), accurate predictions of spatial resolution and noise as a function of FFM are integrated into a task-based objective function. Specifically, detectability index (d'), a common metric for task-based image quality assessment, is computed for a specific formulation of the imaging task. To optimize imaging performance in across an image volume, a maximin objective function was adopted to maximize the minimum detectability index for many locations sampled throughout the volume. To reduce the dimensionality, FFM patterns were represented using wavelet bases, the coefficients of which were optimized using the covariance matrix adaptation evolutionary strategy (CMA-ES) algorithm. The optimization was performed for a mid-frequency discrimination task involving a cluster of micro-calcifications in an abdomen phantom. The task-driven design yielded FFM patterns that were significantly different from traditional strategies proposed for FBP reconstruction. In addition to a higher minimum d' consistent with the objective function, the task-driven approach also improved d' to a greater extent over a larger area of the phantom. Results from this work suggests that FFM strategies suitable for FBP reconstruction need to be reevaluated in the context of MBIR and that a task-driven imaging framework provides a promising approach for such optimization.