Literature DB >> 28058675

Neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors.

T A Gudasheva1, V V Grigoriev2, K N Koliasnikova3, V L Zamoyski2, S B Seredenin3.   

Abstract

We have previously shown that neuropeptide cycloprolylglycine (CPG) increases the content of brain-derived neurotrophic factor (BDNF) in the culture of neuronal cells under normal conditions and in pathology. This is the first study to show that CPG at a physiological concentration of 10-6 M significantly enhances the transmembrane AMPA currents in rat cerebellar Purkinje cells. Thus, CPG is a positive endogenous modulator of AMPA receptors. It was assumed that the neuropsychotropic effects of CPG are implemented as a result of BDNF accumulation after the activation of AMPA receptors by this neuropeptide.

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Year:  2017        PMID： 28058675     DOI： 10.1134/S160767291606003X

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  12 in total

Review 1.  Brain-derived neurotrophic factor and neuropsychiatric disorders.

Authors:  Anita E Autry; Lisa M Monteggia
Journal:  Pharmacol Rev       Date:  2012-03-08       Impact factor: 25.468

2.  Cyclo-Gly-Pro, a cyclic dipeptide, attenuates nociceptive behaviour and inflammatory response in mice.

Authors:  Jamylle Nunes de Souza Ferro; Fernanda Lima Torres de Aquino; Renan Guedes de Brito; Priscila Laíse dos Santos; Jullyana de Souza Siqueira Quintans; Lucas Costa de Souza; Almair Ferreira de Araújo; Bruno Lourenço Diaz; Waldecy Lucca-Júnior; Lucindo José Quintans-Júnior; Emiliano Barreto
Journal:  Clin Exp Pharmacol Physiol       Date:  2015-12       Impact factor: 2.557

3.  AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate.

Authors:  K M Partin; M W Fleck; M L Mayer
Journal:  J Neurosci       Date:  1996-11-01       Impact factor: 6.167

4.  [Identification in the rat brain of cyclo-prolylglycine, a novel endogenous peptide with nootropic activity].

Authors:  T A Gudasheva; S S Boĭko; V Kh Akparov; R U Ostrovskaia; G G Rozantsev; T A Voronina; V P Zherdev; S B Seredenin
Journal:  Dokl Akad Nauk       Date:  1996-10

5.  [Similarity of cycloprolylglycine to piracetam in antihypoxic and neuroprotective effects].

Authors:  K N Kolisnikova; T A Gudasheva; G A Nazarova; T A Antipov; T A Voronina; S B Seredenin
Journal:  Eksp Klin Farmakol       Date:  2012

6.  Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons.

Authors:  J C Lauterborn; G Lynch; P Vanderklish; A Arai; C M Gall
Journal:  J Neurosci       Date:  2000-01-01       Impact factor: 6.167

7.  Neuropeptide cycloprolylglycine increases the levels of brain-derived neurotrophic factor in neuronal cells.

Authors:  T A Gudasheva; K N Koliasnikova; T A Antipova; S B Seredenin
Journal:  Dokl Biochem Biophys       Date:  2016-09-07       Impact factor: 0.788

8.  Identification of a novel endogenous memory facilitating cyclic dipeptide cyclo-prolylglycine in rat brain.

Authors:  T A Gudasheva; S S Boyko; V Kh Akparov; R U Ostrovskaya; S P Skoldinov; G G Rozantsev; T A Voronina; V P Zherdev; S B Seredenin
Journal:  FEBS Lett       Date:  1996-08-05       Impact factor: 4.124

9.  Nootropic drugs positively modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-sensitive glutamate receptors in neuronal cultures.

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Journal:  J Neurochem       Date:  1992-04       Impact factor: 5.372

10.  Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation.

Authors:  Hussam Jourdi; Yu-Tien Hsu; Miou Zhou; Qingyu Qin; Xiaoning Bi; Michel Baudry
Journal:  J Neurosci       Date:  2009-07-08       Impact factor: 6.167
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  1 in total

1.  A New Component in the Mechanism of Regulation of Endogenous Depressive-Like States.

Authors:  T L Garibova; T A Gudasheva; S B Seredenin
Journal:  Dokl Biochem Biophys       Date:  2019-11-25       Impact factor: 0.788
  1 in total

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