Literature DB >> 22407616

Brain-derived neurotrophic factor and neuropsychiatric disorders.

Anita E Autry1, Lisa M Monteggia.   

Abstract

Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central nervous system (CNS). It is essential for the development of the CNS and for neuronal plasticity. Because BDNF plays a crucial role in development and plasticity of the brain, it is widely implicated in psychiatric diseases. This review provides a summary of clinical and preclinical evidence for the involvement of this ubiquitous growth factor in major depressive disorder, schizophrenia, addiction, Rett syndrome, as well as other psychiatric and neurodevelopmental diseases. In addition, the review includes a discussion of the role of BDNF in the mechanism of action of pharmacological therapies currently used to treat these diseases, such antidepressants and antipsychotics. The review also covers a critique of experimental therapies such as BDNF mimetics and discusses the value of BDNF as a target for future drug development.

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Year:  2012        PMID： 22407616      PMCID： PMC3310485          DOI： 10.1124/pr.111.005108

Source DB:  PubMed          Journal:  Pharmacol Rev        ISSN： 0031-6997            Impact factor:   25.468


  228 in total

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2.  Family-based study of brain-derived neurotrophic factor (BDNF) gene polymorphism in alcohol dependence.

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Journal:  Pharmacol Rep       Date:  2010 Sep-Oct       Impact factor: 3.024

3.  The BDNF Val66Met polymorphism and anxiety: support for animal knock-in studies from a genetic association study in humans.

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4.  Toward neurotrophin-based therapeutics.

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5.  Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning.

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6.  Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders.

Authors:  Mia Thompson Ray; Cynthia Shannon Weickert; Eugene Wyatt; Maree J Webster
Journal:  J Psychiatry Neurosci       Date:  2011-05       Impact factor: 6.186

Review 7.  The role of BDNF in depression on the basis of its location in the neural circuitry.

Authors:  Hui Yu; Zhe-yu Chen
Journal:  Acta Pharmacol Sin       Date:  2010-12-06       Impact factor: 6.150

Review 8.  Variant brain-derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorder.

Authors:  Helena Frielingsdorf; Kevin G Bath; Fatima Soliman; JoAnn Difede; B J Casey; Francis S Lee
Journal:  Ann N Y Acad Sci       Date:  2010-10       Impact factor: 5.691

9.  Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward.

Authors:  Mary Kay Lobo; Herbert E Covington; Dipesh Chaudhury; Allyson K Friedman; HaoSheng Sun; Diane Damez-Werno; David M Dietz; Samir Zaman; Ja Wook Koo; Pamela J Kennedy; Ezekiell Mouzon; Murtaza Mogri; Rachael L Neve; Karl Deisseroth; Ming-Hu Han; Eric J Nestler
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Review 10.  Review: The neuropathology of drug abuse.

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  427 in total

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Review 3.  Targeting the glutamatergic system to treat major depressive disorder: rationale and progress to date.

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Journal:  Drugs       Date:  2012-07-09       Impact factor: 9.546

Review 4.  Psychiatric drugs bind to classical targets within early exocytotic pathways: therapeutic effects.

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Review 5.  Omental transplantation for neuroendocrinological disorders.

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Review 6.  The Dynamics of Neurosteroids and Sex-Related Hormones in the Pathogenesis of Alzheimer's Disease.

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7.  Regulation of brain-derived neurotrophic factor expression in neurons.

Authors:  Fei Zheng; Xianju Zhou; Changjong Moon; Hongbing Wang
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2012-12-26

8.  Novel antidepressant effects of Paeonol alleviate neuronal injury with concomitant alterations in BDNF, Rac1 and RhoA levels in chronic unpredictable mild stress rats.

Authors:  Xiu-Ling Zhu; Jing-Jing Chen; Fei Han; Chuan Pan; Ting-Ting Zhuang; Ya-Fei Cai; Ya-Ping Lu
Journal:  Psychopharmacology (Berl)       Date:  2018-05-12       Impact factor: 4.530

9.  Maternal low-protein diet decreases brain-derived neurotrophic factor expression in the brains of the neonatal rat offspring.

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Journal:  J Nutr Biochem       Date:  2017-04-06       Impact factor: 6.048

Review 10.  The organization of the stress system and its dysregulation in depressive illness.

Authors:  P W Gold
Journal:  Mol Psychiatry       Date:  2014-12-09       Impact factor: 15.992
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