Literature DB >> 8706904

Identification of a novel endogenous memory facilitating cyclic dipeptide cyclo-prolylglycine in rat brain.

T A Gudasheva1, S S Boyko, V Kh Akparov, R U Ostrovskaya, S P Skoldinov, G G Rozantsev, T A Voronina, V P Zherdev, S B Seredenin.   

Abstract

Using high-performance liquid chromatography, gas-chromatography and chromato-mass spectrometry methods a novel endogenous cyclic dipeptide cyclo-prolylglycine was identified in rat brain. Its content according to gas chromatography is 2.8 +/- 0.3 nmol/g wet brain. Synthetic cyclo-prolylglycine has demonstrated antiamnesic activity in the passive avoidance test in rats at a dose of 0.1 mg/kg i.p. Cyclic dipeptide cyclo-prolylglycine seems to be a memory facilitating substance and its presence in rat brain suggests the existence of a new mechanism of memory regulation.

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Year:  1996        PMID： 8706904     DOI： 10.1016/0014-5793(96)00722-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  2,5-Diketopiperazines produced by Bacillus pumilus during bacteriolysis of Arthrobacter citreus.

Authors:  Christiane Brack; Annett Mikolasch; Frieder Schauer
Journal:  Mar Biotechnol (NY)       Date:  2014-01-22       Impact factor: 3.619

2.  A New Component in the Mechanism of Regulation of Endogenous Depressive-Like States.

Authors:  T L Garibova; T A Gudasheva; S B Seredenin
Journal:  Dokl Biochem Biophys       Date:  2019-11-25       Impact factor: 0.788

3.  Neuropeptide cycloprolylglycine increases the levels of brain-derived neurotrophic factor in neuronal cells.

Authors:  T A Gudasheva; K N Koliasnikova; T A Antipova; S B Seredenin
Journal:  Dokl Biochem Biophys       Date:  2016-09-07       Impact factor: 0.788

4.  The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclo-L-prolylglycine.

Authors:  T A Gudasheva; S S Boyko; R U Ostrovskaya; T A Voronina; V K Akparov; S S Trofimov; G G Rozantsev; A P Skoldinov; V P Zherdev; S B Seredenin
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1997 Jul-Sep       Impact factor: 2.441

5.  Neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors.

Authors:  T A Gudasheva; V V Grigoriev; K N Koliasnikova; V L Zamoyski; S B Seredenin
Journal:  Dokl Biochem Biophys       Date:  2017-01-06       Impact factor: 0.788

6.  Metabolism of a New Dipeptide Neuroprotector in Rats.

Authors:  G B Kolyvanov; P O Bochkov; A A Litvin; R V Shevchenko; A L Podol'ko; O Yu Kravtsova; K N Kolyasnikova; V P Zherdev
Journal:  Bull Exp Biol Med       Date:  2022-03-30       Impact factor: 0.804

7.  Protective Effects of Hydrolyzed Chicken Extract (Probeptigen®/Cmi-168) on Memory Retention and Brain Oxidative Stress in Senescence-Accelerated Mice.

Authors:  Ming-Yu Chou; Ying-Ju Chen; Liang-Hung Lin; Yoshihiro Nakao; Ai Lin Lim; Ming-Fu Wang; Shan May Yong
Journal:  Nutrients       Date:  2019-08-12       Impact factor: 5.717

8.  Molecular Mechanism Underlying the Action of Substituted Pro-Gly Dipeptide Noopept.

Authors:  Y V Vakhitova; S V Sadovnikov; S S Borisevich; R U Ostrovskaya; T A Gudasheva; S B Seredenin
Journal:  Acta Naturae       Date:  2016 Jan-Mar       Impact factor: 1.845

9.  Hydrolyzed Chicken Extract (ProBeptigen®) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial.

Authors:  Dean Wu; Cheng-Chang Yang; Kuan-Yu Chen; Ying-Chin Lin; Pei-Jung Wu; Pei-Hsiu Hsieh; Yoshihiro Nakao; Mandy Y L Ow; Yi-Chen Hsieh; Chaur-Jong Hu
Journal:  Nutrients       Date:  2020-05-10       Impact factor: 5.717

Review 10.  Novel Technologies for Dipeptide Drugs Design and their Implantation.

Authors:  Tatiana A Gudasheva; Rita U Ostrovskaya; Sergey B Seredenin
Journal:  Curr Pharm Des       Date:  2018       Impact factor: 3.116
  10 in total

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