| Literature DB >> 28056427 |
Yue Zhang1, Fei Fei1, Le Zhen1, Xuanxuan Zhu2, Jiankun Wang1, Sijia Li1, Jianliang Geng1, Runbin Sun1, Xiaoyi Yu1, Tingting Chen3, Siqi Feng1, Pei Wang1, Na Yang1, Yejin Zhu1, Jingqiu Huang1, Yuqing Zhao1, Jiye Aa4, Guangji Wang1.
Abstract
Crocin and crocetin in rat plasma were simultaneously analysed using ultra-performance liquid chromatography tandem mass spectroscopy (UPLC-MS/MS), and method was fully validated. For the first time, levels of both crocin and crocetin in plasma were profiled after oral administration of crocin, and this UPLC-MS/MS approach was applied to evaluate pharmacokinetics and relative bioavailability of crocin and crocetin in rats. It was shown that crocin transformed into crocetin quickly in the gastrointestinal tract, and crocetin was 56-81 fold higher exposed in rat plasma than crocin after oral administration of crocin. A comparison study revealed that an oral administration of equal molar crocin achieved higher exposure of crocetin in rat plasma than that of crocetin. It was suggested that oral administration of crocin has the advantages over crocetin, and crocetin may be the active component potentially responsible for the pharmacological effect of crocin.Entities:
Keywords: Bioavailability; Crocetin; Crocin; LC–MS/MS; Pharmacokinetics
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Year: 2016 PMID： 28056427 DOI： 10.1016/j.jchromb.2016.12.003
Source DB: PubMed Journal: J Chromatogr B Analyt Technol Biomed Life Sci ISSN： 1570-0232 Impact factor: 3.205